South Main

Houston

A city skyline with modern buildings and a park with a lake.
A modern urban street with a metro train, buildings, and a clear blue sky.

Things to do

Houston Museum of Natural Sciences: Planetarium Ticket

Houston Museum of Natural Sciences: Planetarium Ticket

€11
per adult
82% of travellers recommend
Houston Museum of Natural Sciences: Planetarium Ticket
HOP ON- HOP OFF

Houston's Official City & Mural Tour!

€36
per adult
88% of travellers recommend
Houston's Official City & Mural Tour!
Houston Museum of Natural Science: Cockrell Butterfly Center

Houston Museum of Natural Science: Butterfly Center Ticket

€13
per adult
100% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
Houston: Houston Botanic Garden Entry Ticket

Houston: Houston Botanic Garden Entry Ticket

€11
per adult
74% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
Houston: Holocaust Museum Houston Entry Ticket

Houston: Holocaust Museum Houston Entry Ticket

€20
per adult
90% of travellers recommend
Houston: Holocaust Museum Houston Entry Ticket
Houston: Museum of Natural Science General Admission Ticket

Houston: Museum of Natural Science General Admission Ticket

€22
per adult
98% of travellers recommend
Houston: Museum of Natural Science General Admission Ticket
See all activities in Houston

Top hotels in South Main

Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
The price is €93 per night from 18 Oct to 19 Oct
€93
18 Oct - 19 Oct
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, a 24-hour fitness centre and a 24-hour front desk. Our guests praise the helpful staff and ...
Wyndham Houston at Reliant Park & Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
The price is €111 per night from 19 Oct to 20 Oct
€111
19 Oct - 20 Oct
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the restaurant and the helpful staff ...
8.6/10 Excellent! (4,536 reviews)
"Very cozy and quaint hotel. Fluffy pillows and a comfortable bed."

Reviewed on 16 Oct 2026

Club Quarters Hotel Downtown, Houston
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
The price is €145 per night from 16 Nov to 17 Nov
€145
16 Nov - 17 Nov
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and ...
8.6/10 Excellent! (2,459 reviews)
"Everything is great but that parking price and situation is unfair. Also charged my card extra… I got an extra 4 hours for $100 and they charged 277 on my card also made me switch rooms on Saturday night…."

Reviewed on 16 Oct 2026

The Whitehall Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
The price is €133 per night from 29 Oct to 30 Oct
€133
29 Oct - 30 Oct
includes taxes & fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and the clean ...
8.4/10 Very good! (4,589 reviews)
"Personal amable. Hotel muy limpio."

Reviewed on 15 Oct 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
The price is €106 per night from 29 Oct to 30 Oct
€106
29 Oct - 30 Oct
includes taxes & fees
Stay at this family-friendly hotel in Houston. Enjoy free Wi-Fi, an outdoor pool and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
Grand Tuscany Hotel
Hyatt Regency Houston West

Hyatt Regency Houston West

3.5 out of 5
13210 Katy Fwy Houston TX
The price is €108 per night from 1 Nov to 2 Nov
€108
1 Nov - 2 Nov
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the restaurant and the helpful staff ...
Hyatt Regency Houston West
See all 7,438 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

South Main

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