What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on our traveller data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from NRG Park, and it offers a restaurant and an outdoor pool.

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 61 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

South Main hotels, Houston, United States of America: Houston Hotel Guide

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Our top choices for South Main hotels

1. Wyndham Houston at Reliant Park & Medical Center

South Main

Timothy

includes taxes & fees

7 Sept - 8 Sept

2. Comfort Suites Houston near Medical Center- NRG Stadium

South Main

Linda

includes taxes & fees

8 Sept - 9 Sept

3. Wingate Houston at Reliant Park & Medical Center

South Main

Terry

includes taxes & fees

10 Sept - 11 Sept

4. Quality Inn & Suites NRG Park - Medical Center

South Main

Oscar

includes taxes & fees

14 Sept - 15 Sept

5. Candlewood Suites Houston Medical Center by IHG

South Main

Michelle

includes taxes & fees

14 Sept - 15 Sept

6. Hotel Ylem

2.3 km from South Main

Meryem

includes taxes & fees

9 Sept - 10 Sept

7. Courtyard By Marriott Houston Medical Center Reliant Park

2.7 km from South Main

Jorge

includes taxes & fees

11 Sept - 12 Sept

8. Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

JEAN MICHEL

includes taxes & fees

6 Sept - 7 Sept

9. Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Leland

includes taxes & fees

7 Sept - 8 Sept

10. Hilton Houston Plaza/Medical Center

Texas Medical Center, 4.4 km from South Main

Cindy

includes taxes & fees

7 Sept - 8 Sept

11. The Westin Houston Medical Center/Museum District

Texas Medical Center, 4.4 km from South Main

Stanley

includes taxes & fees

6 Sept - 7 Sept

12. DoubleTree by Hilton Hotel Houston - Greenway Plaza

Greenway Plaza-Upper Kirby, 6.6 km from South Main

Raphael

includes taxes & fees

14 Sept - 15 Sept

13. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Greenway Plaza-Upper Kirby, 6.5 km from South Main

Lanita

includes taxes & fees

8 Sept - 9 Sept

14. Hotel Zaza Houston Museum District

6.3 km from South Main

Chaniquah

includes taxes & fees

2 Sept - 3 Sept

15. Home2 Suites by Hilton at the Galleria

Greater Uptown, 8 km from South Main

Tyson

includes taxes & fees

6 Sept - 7 Sept

16. Holiday Inn Express Houston - Galleria Area by IHG

The Galleria, 8.6 km from South Main

Michelle

includes taxes & fees

4 Sept - 5 Sept

17. The Royal Sonesta Houston Galleria

The Galleria, 8.8 km from South Main

Tristan

includes taxes & fees

3 Sept - 4 Sept

18. Hyatt Place Houston/Galleria

8.7 km from South Main

Natasha

includes taxes & fees

2 Sept - 3 Sept

19. Best Western Plus Downtown Inn & Suites

10.2 km from South Main

ROMAN

includes taxes & fees

13 Sept - 14 Sept

20. Sonesta ES Suites Houston Galleria

The Galleria, 8.4 km from South Main

Mikhail

includes taxes & fees

1 Sept - 2 Sept

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Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

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Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

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A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

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A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

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An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.

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A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

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