A city skyline with modern buildings and a park with a lake.

Houston Hotel Guide. Hotels in South Main, Houston, United States of America

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Check prices for these dates

This weekend
17 Jul - 19 Jul
Next weekend
24 Jul - 26 Jul

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Our top choices for South Main hotels

Premium bedding, pillow-top beds, in-room safe, desk

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,343 reviews)
"Location"
United States
Gurgen
The price is €94
includes taxes & fees
2 Aug - 3 Aug
Wyndham Houston near NRG Park/Medical Center
Individually decorated, individually furnished, desk, laptop workspace

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,014 reviews)
"Very good all around. Very close to the stadium."
Canada
marty
The price is €87
includes taxes & fees
8 Aug - 9 Aug
Comfort Suites Houston near Medical Center- NRG Stadium
Lobby

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,008 reviews)
"Good parking"
United States
joseph
The price is €86
includes taxes & fees
15 Aug - 16 Aug
Wingate Houston near NRG Park/Medical Center
Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,003 reviews)
"convenient to medical center"
United States
Mike
The price is €60
includes taxes & fees
16 Aug - 17 Aug
Quality Inn & Suites NRG Park - Medical Center
Exterior

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (886 reviews)
"This place had"
United States
Marvin
The price is €70
includes taxes & fees
30 Jul - 31 Jul
Candlewood Suites Houston Medical Center by IHG
Lobby

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (349 reviews)
"Clean quiet rooms nice breakfast great staff"
United States
Keitha
The price is €87
includes taxes & fees
21 Jul - 22 Jul
Best Western Plus Pearland/Houston Medical Center Hotel
Lobby sitting area

Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 12.9 km from South Main
9.2 out of 10, Wonderful, (156 reviews)
"Clean room & nice location"
United States
Andres
The price is €58
includes taxes & fees
31 Jul - 1 Aug
Studio 6 Houston, TX – Pearland/Medical Center
Luxury Room, 1 King Bed, Hot Tub

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (182 reviews)
"Best choice I made was going here wish I had picked just this one to stay at while in houston"
United States
William
The price is €115
includes taxes & fees
22 Jul - 23 Jul
Palace Inn Blue Edgebrook
Buffet breakfast for a fee on weekends

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,040 reviews)
"Wonderful staff , delicious breakfast, a nice pool A great service all around"
United States
Mohamed M
The price is €101
includes taxes & fees
31 Jul - 1 Aug
Doubletree by Hilton Houston Hobby Airport
Lobby

Palace Inn Blue 290 W 43rd & Bingle Rd

Palace Inn Blue 290 W 43rd & Bingle Rd
2.5 star property
19.4 km from South Main
9.0 out of 10, Wonderful, (98 reviews)
"I booked last minute, and everything was amazing. Great stay and very clean"
United States
Satavia
The price is €79
includes taxes & fees
18 Jul - 19 Jul
Palace Inn Blue 290 W 43rd & Bingle Rd
Terrace/patio

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,255 reviews)
"We had a quick overnight stay but the proximity to the airport and the friendly staff made the experience wonderful!!"
United States
Jeremy
The price is €121
includes taxes & fees
30 Jul - 31 Jul
Courtyard by Marriott Houston Intercontinental Airport
Exterior

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.0 out of 10, Wonderful, (49 reviews)
"Great space"
United States
Domingos
The price is €83
includes taxes & fees
17 Jul - 18 Jul
Hotel Royale
Restaurant

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Nice stay Overall nice and quiet stay."
United States
Jesus
The price is €92
includes taxes & fees
3 Aug - 4 Aug
Tru by Hilton Houston Webster NASA
Lobby

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.0 out of 10, Very good, (2,333 reviews)
"Great hotel, staff was really helpful."
United States
Samuel Josué
The price is €86
includes taxes & fees
22 Jul - 23 Jul
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Terrace/patio

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,026 reviews)
"Great place to stay at super clean and nice area and everything was nearby"
United States
Marvin
The price is €112
includes taxes & fees
16 Aug - 17 Aug
Hilton Houston Plaza/Medical Center
Exterior

The Moran CITYCENTRE

The Moran CITYCENTRE
4.0 star property
18.3 km from South Main
9.0 out of 10, Wonderful, (1,109 reviews)
"Great place"
United States
Sarai
The price is €190
includes taxes & fees
26 Jul - 27 Jul
The Moran CITYCENTRE
Premium bedding, pillow-top beds, minibar, in-room safe

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
6.3 km from South Main
9.2 out of 10, Wonderful, (1,002 reviews)
"Great place to stay"
United States
Gayathry
The price is €277
includes taxes & fees
20 Jul - 21 Jul
Hotel Zaza Houston Museum District
Breakfast, lunch and dinner served

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.6 out of 10, Excellent, (4,335 reviews)
"Clean rooms and nice stay"
United States
Julia
The price is €103
includes taxes & fees
2 Aug - 3 Aug
Club Quarters Hotel Downtown, Houston
Lobby

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,286 reviews)
"The hotel is adequate for a short stay , the front desk personnel was excellent , free parking , average breakfast ."
United States
Ronald
The price is €84
includes taxes & fees
19 Jul - 20 Jul
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
View from property

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Houston Central Business District, 11 km from South Main
9.2 out of 10, Wonderful, (1,573 reviews)
"Room was clean bar was nice"
United States
Stephanie
The price is €121
includes taxes & fees
1 Aug - 2 Aug
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,014 reviews
View
Premium bedding, pillow-top beds, in-room safe, desk
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,343 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,008 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,003 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
886 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

10/10 Excellent
"This property was absolutely beautiful from the cleanliness to the top-tier customer service from the staff to the aesthetics of the entire property. I highly recommend the state if you’re going to be in the Houston Texas area you won’t regret it."
Shannon 3-night trip
Posted 5 hours ago
Blossom Hotel Houston, Curio Collection by Hilton

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Looking for sights you might find in a travel guide about South Main? Consider a visit to NRG Park while you're in the neighbourhood.
Where is the best hotel for a stay in South Main?
Based on our traveller data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers a restaurant and an outdoor pool.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 61 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
Popular attractions in South Main include NRG Park. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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