Houston Hotel Guide. Hotels in South Main, Houston, United States of America

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Our top choices for South Main hotels

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,014 reviews)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is €99
includes taxes & fees
19 Jan - 20 Jan
Comfort Suites Houston near Medical Center- NRG Stadium

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (829 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is €78
includes taxes & fees
14 Jan - 15 Jan
Candlewood Suites Houston Medical Center by IHG

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,001 reviews)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is €61
includes taxes & fees
11 Feb - 12 Feb
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (996 reviews)
"Easy access to stadium "
United States
Richard
The price is €99
includes taxes & fees
10 Feb - 11 Feb
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,203 reviews)
"Front desk staff was very professional and kind."
United States
MARINA
The price is €117
includes taxes & fees
13 Jan - 14 Jan
Wyndham Houston near NRG Park/Medical Center

Four Points by Sheraton Houston Intercontinental Airport

Four Points by Sheraton Houston Intercontinental Airport
3.0 star property
29.9 km from South Main
8.4 out of 10, Very good, (1,010 reviews)
"This place was amazing! Stayed in 4 places in days, this was the absolute best !"
United States
Debra
The price is €84
includes taxes & fees
16 Jan - 17 Jan
Four Points by Sheraton Houston Intercontinental Airport

Days Inn & Suites by Wyndham Houston Hobby Airport

Days Inn & Suites by Wyndham Houston Hobby Airport
2.5 star property
15.8 km from South Main
8.6 out of 10, Excellent, (1,005 reviews)
"Awesome friendly staff and spotless rooms. Kudos to the manager."
United States
Mauricio
The price is €74
includes taxes & fees
13 Jan - 14 Jan
Days Inn & Suites by Wyndham Houston Hobby Airport

Comfort Suites Houston West at Clay Road

Comfort Suites Houston West at Clay Road
2.5 star property
22.8 km from South Main
8.4 out of 10, Very good, (1,001 reviews)
"Safe hotel"
United States
Nick
The price is €73
includes taxes & fees
22 Jan - 23 Jan
Comfort Suites Houston West at Clay Road

Homewood Suites By Hilton Houston IAH Airport Beltway 8

Homewood Suites By Hilton Houston IAH Airport Beltway 8
3.0 star property
29.9 km from South Main
8.4 out of 10, Very good, (930 reviews)
"The staff were very helpful and friendly. The rooms were very clean and comfortable. I’d book there again as it’s close to the airport and out of the congestion of the City."
United States
Mlela
The price is €82
includes taxes & fees
18 Jan - 19 Jan
Homewood Suites By Hilton Houston IAH Airport Beltway 8

Hilton Garden Inn Houston/Bush Intercontinental Airport

Hilton Garden Inn Houston/Bush Intercontinental Airport
3.0 star property
31.1 km from South Main
8.4 out of 10, Very good, (1,015 reviews)
"It was a great stay "
United States
Thrideep
The price is €88
includes taxes & fees
23 Jan - 24 Jan
Hilton Garden Inn Houston/Bush Intercontinental Airport

Quality Suites Houston Hobby Airport

Quality Suites Houston Hobby Airport
2.5 star property
Southeast Houston, 13.3 km from South Main
8.4 out of 10, Very good, (1,300 reviews)
"Very comfortable clean and all around great stay"
United States
Landy
The price is €64
includes taxes & fees
19 Jan - 20 Jan
Quality Suites Houston Hobby Airport

GreenTree Inn Houston IAH Airport

GreenTree Inn Houston IAH Airport
2.0 star property
31.4 km from South Main
6.6 out of 10, (1,003 reviews)
"Good place for a stay"
United States
Cintra
The price is €54
includes taxes & fees
13 Jan - 14 Jan
GreenTree Inn Houston IAH Airport

DoubleTree by Hilton Houston Intercontinental Airport

DoubleTree by Hilton Houston Intercontinental Airport
4.0 star property
31.5 km from South Main
8.4 out of 10, Very good, (1,004 reviews)
"Clean rooms, friendly staff. Yummy warm cookies upon checkin! "
United States
Amanda
The price is €131
includes taxes & fees
30 Jan - 31 Jan
DoubleTree by Hilton Houston Intercontinental Airport

Hampton Inn & Suites Houston Medical Center NRG Park

Hampton Inn & Suites Houston Medical Center NRG Park
2.5 star property
Texas Medical Center, 3 km from South Main
8.2 out of 10, Very good, (1,005 reviews)
"Clean, staff was great. "
United States
Lavetta
The price is €103
includes taxes & fees
18 Jan - 19 Jan
Hampton Inn & Suites Houston Medical Center NRG Park

WoodSpring Suites Houston Northwest

WoodSpring Suites Houston Northwest
2.5 star property
23.8 km from South Main
7.6 out of 10, Good, (515 reviews)
"Great experience!!"
United States
Bryant
The price is €60
includes taxes & fees
13 Jan - 14 Jan
WoodSpring Suites Houston Northwest

Four Points by Sheraton Houston Hobby Airport

Four Points by Sheraton Houston Hobby Airport
3.0 star property
Southeast Houston, 15.3 km from South Main
7.8 out of 10, Good, (1,000 reviews)
"Air conditioner was just fine, a sage place to stay."
United States
Valorie
The price is €60
includes taxes & fees
13 Jan - 14 Jan
Four Points by Sheraton Houston Hobby Airport

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
3.0 star property
28.8 km from South Main
9.0 out of 10, Wonderful, (974 reviews)
"Area is nice and quiet. Hotel was clean. "
United States
Isabel
The price is €80
includes taxes & fees
15 Jan - 16 Jan
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

Hampton Inn & Suites Houston I-10 West Park Row

Hampton Inn & Suites Houston I-10 West Park Row
2.5 star property
29.3 km from South Main
8.8 out of 10, Excellent, (670 reviews)
"Great staff, Clean room. "
United States
Corliss
The price is €84
includes taxes & fees
15 Jan - 16 Jan
Hampton Inn & Suites Houston I-10 West Park Row

Moxy Houston Downtown

Moxy Houston Downtown
3.0 star property
Downtown Houston, 11.2 km from South Main
8.8 out of 10, Excellent, (697 reviews)
"Staff was very pleasant and the rooms were clean."
United States
Elizabeth
The price is €101
includes taxes & fees
18 Jan - 19 Jan
Moxy Houston Downtown

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (153 reviews)
"Such a great place to stay! Absolutely amazing!"
United States
Charlette
The price is €103
includes taxes & fees
13 Jan - 14 Jan
Palace Inn Blue Edgebrook
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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