A city skyline with modern buildings and a park with a lake.

Houston Hotel Guide. Hotels in South Main, Houston, United States of America

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Check prices for these dates

This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for South Main hotels

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

1. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,004 reviews)
"Clean rooms and staff is great."
United States
Tamy
The price is €94
includes taxes & fees
22 Oct - 23 Oct
Comfort Suites Houston near Medical Center- NRG Stadium
A modern lobby with a blue carpet, seating area, and large windows.

2. Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,458 reviews)
"Great stay!!"
United States
Matthew
The price is €93
includes taxes & fees
26 Oct - 27 Oct
Wyndham Houston at Reliant Park & Medical Center
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.

3. Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,001 reviews)
"We had a excellent stay"
United States
Jasmine
The price is €67
includes taxes & fees
16 Nov - 17 Nov
Quality Inn & Suites NRG Park - Medical Center
A spacious lobby with a central seating area, a bar, and a reception desk.

4. Wingate Houston near Reliant Park/Medical Center

Wingate Houston near Reliant Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,000 reviews)
"Great place"
United States
Crystal
The price is €93
includes taxes & fees
29 Oct - 30 Oct
Wingate Houston near Reliant Park/Medical Center
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.

5. Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (899 reviews)
"Amazing friendly staff."
United States
Olga
The price is €77
includes taxes & fees
18 Oct - 19 Oct
Candlewood Suites Houston Medical Center by IHG
A courtyard with a pathway, a small garden, and a building with a sign indicating the number 8423.

6. 3 BR Condo near Reliant/NRG Stadium

3 BR Condo near Reliant/NRG Stadium
2.0 star property
South Main
8.0 out of 10, Very good, (1 review)
"Checkin was unpleasant because I was given the wrong lockbox information and had trouble reaching the management company. Finally I did and after an hour I got the key. They the WiFi didn’t work and I couldn’t reach anyone - another frustrating hour wasted. The hidden router just needed to be plugged in. The place itself was very comfortable and very convenient for the Reliant Stadium."
United States
Jeffrey
The price is €333
includes taxes & fees
30 Oct - 31 Oct
3 BR Condo near Reliant/NRG Stadium
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
1.4 km from South Main
9.4 out of 10, Exceptional, (1,004 reviews)
"Very clean, friendly staff and great breakfast."
United States
Elisa
The price is €120
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.

8. Hotel Ylem

Hotel Ylem
3.5 star property
2.3 km from South Main
8.4 out of 10, Very good, (1,576 reviews)
"clean hotel, very nice I enjoyed my stay!"
United States
aundrea
The price is €78
includes taxes & fees
10 Nov - 11 Nov
Hotel Ylem
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

9. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,287 reviews)
"Great location and the bed was amazingly comfortable!!"
United States
Debra
The price is €133
includes taxes & fees
29 Oct - 30 Oct
Hyatt House Houston Medical Center
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

10. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,710 reviews)
"Will stay again, convenient location"
United States
Dominie
The price is €133
includes taxes & fees
15 Nov - 16 Nov
Hyatt Place Houston Medical Center
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

11. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,198 reviews)
"Room was great, staff was helpful"
United States
Marvin
The price is €115
includes taxes & fees
7 Nov - 8 Nov
Hilton Houston Plaza/Medical Center
A spacious lobby with plush seating, a marble coffee table, and a grand chandelier.

12. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,824 reviews)
"Beautifully appointed boutique hotel with a convenient location and excellent service."
United States
Rebecca
The price is €163
includes taxes & fees
25 Oct - 26 Oct
Blossom Hotel Houston, Curio Collection by Hilton
A rooftop pool area with lounge chairs and a view of a tall building at night.

13. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,247 reviews)
"Great place"
United States
Matthew
The price is €178
includes taxes & fees
8 Nov - 9 Nov
The Westin Houston Medical Center/Museum District
A person sitting on a white lounge chair with a striped towel, reading a book.

14. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
Greenway Plaza-Upper Kirby, 6.5 km from South Main
7.8 out of 10, Good, (1,705 reviews)
"Super nice stay"
United States
Dustin
The price is €72
includes taxes & fees
15 Nov - 16 Nov
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
A spacious living area with a dining table, chairs, and a chandelier.

15. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
6.3 km from South Main
9.2 out of 10, Wonderful, (1,001 reviews)
"Great place!"
United States
Madiha
The price is €260
includes taxes & fees
18 Oct - 19 Oct
Hotel Zaza Houston Museum District
A hotel entrance with a covered walkway, a 'No Parking' sign, and a 'Home 2 Suites by Hilton' sign.

16. Home2 Suites by Hilton at the Galleria

Home2 Suites by Hilton at the Galleria
3.0 star property
Greater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,055 reviews)
"Access to the gym and pool facilities 24/7 and breakfast each morning is was great. It’s definitely on my list to stay again when I’m back in town."
United States
Dwan
The price is €110
includes taxes & fees
1 Nov - 2 Nov
Home2 Suites by Hilton at the Galleria
A reception area with a wooden reception desk, two refrigerators, and clocks displaying different city names.

17. Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (464 reviews)
"Happy to stayed there!"
United States
AYTUNC
The price is €102
includes taxes & fees
29 Oct - 30 Oct
Best Western Plus Pearland/Houston Medical Center Hotel
A modern hotel with a prominent glass facade, a well-maintained lawn, and a clear sky.

18. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
Greenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very good, (1,936 reviews)
"The staff was very courteous and made our stay very welcoming ."
United States
Yvonne
The price is €114
includes taxes & fees
25 Oct - 26 Oct
DoubleTree by Hilton Hotel Houston - Greenway Plaza
A modern indoor pool area with a wooden table and chairs, a vase with flowers, and a view of the outside buildings.

19. Best Western Plus Downtown Inn & Suites

Best Western Plus Downtown Inn & Suites
3.0 star property
10.2 km from South Main
9.2 out of 10, Wonderful, (1,116 reviews)
The price is €122
includes taxes & fees
25 Oct - 26 Oct
Best Western Plus Downtown Inn & Suites
A hotel lobby with a hot tub, a pool, and a dining area.

20. Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
3.0 star property
The Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,562 reviews)
"Comfortable stay, good breakfast."
United States
Pamela
The price is €116
includes taxes & fees
23 Oct - 24 Oct
Drury Inn & Suites Houston Near the Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,004 reviews
View
A compact kitchen with dark cabinets, a microwave, a coffee maker, and a white countertop. There are two wicker chairs and a small table.
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
899 reviews
View
A modern lobby with a blue carpet, seating area, and large windows.
Wyndham Houston at Reliant Park & Medical Center
3.5 star property
7.2
Good
1,458 reviews
View
A hotel room with a blue sofa, striped armchair, a small table, a TV on a cabinet, a microwave, and a door leading to a bedroom.
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,001 reviews
View
A spacious lobby with a central seating area, a bar, and a reception desk.
Wingate Houston near Reliant Park/Medical Center
3.0 star property
6.6
1,000 reviews
View

Hotels recommended for families in South Main

A hotel room with a large bathtub, a bed with white bedding, a wooden headboard, and a nightstand with a lamp.

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,004)
The price is €94
includes taxes & fees
22 Oct - 23 Oct
Comfort Suites Houston near Medical Center- NRG Stadium

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Heritage Place Houston Brookhollow

Heritage Place Houston Brookhollow

10/10 Excellent
"Simple quick and easy good sleep close to highway and gas station"
Matthew 1-night trip
Posted 3 hours ago
Heritage Place Houston Brookhollow

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to Reliant Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveller data, Wyndham Houston at Reliant Park & Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from Reliant Park, and it offers a restaurant and an outdoor pool.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
Reliant Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as Reliant Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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