South Main Holidays
- Plan, book, travel with confidence
- Better togetherSave up to €900 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Downtown Houston
3 out of top 10 points of interest in this area
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
1 out of top 10 points of interest in this area
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top hotels in South Main
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
€108
7 Sept - 8 Sept
includes taxes & fees
8.4/10 Very good! (4,455 reviews)
"Great for a weekend getaway"
Reviewed on 31 Aug 2026
Club Quarters Hotel Downtown, Houston
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
€111
14 Sept - 15 Sept
includes taxes & fees
8.6/10 Excellent! (4,508 reviews)
"The room was clean and the staff was great. First time staying here for my birthday weekend and also wedding…"
Reviewed on 31 Aug 2026
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
€83
7 Sept - 8 Sept
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a South Main holiday package cost?
Get set to book, because a getaway to South Main starts from an enticing . When you combine your flights, hotels and more into a travel package, you'll walk away with the best bargains.
How do I get a cheap travel package to South Main?
You'll save tons of cash if you bundle your car rentals, hotels and flights into a South Main holiday package. Sometimes cheap means fewer options. But that's not the case with Expedia. We offer over 550 airlines and 1,000,000 hotels across the globe, which means you'll always have plenty of variety to choose from. Like to save even more? Add some interesting activities to your package deal to unlock even bigger bargains! After all, travel is about more than just getting to your destination.
Where should I stay in South Main?
Book a hotel within walking distance of Houston Zoo, one of this neighbourhood's most popular attractions. It's the perfect spot if you're an eager sightseer.
What are the top hotels in South Main?
Get your trip off to a fantastic start by booking a stay at Travellers Dream 1bd 1 Bath Getaway. It's one of most popular hotels in South Main. Another welcoming option is Luxury King And Queen 1bedroom Suite | Nrg Stadium | Medical Ctr | Galleria | Downtown.
How far in advance should I book my South Main holiday?
It all depends on the air carrier, but you can usually browse through international airfares on Expedia nearly a year in advance. While it's a good idea to book ahead of time, lucky customers occasionally find a cheaper seat just weeks before the date of departure.
What does an Expedia South Main travel package include?
Flights, car rentals and hotels — we bring you all the best deals. All you have to do is figure out your favourite combination. Once you've made your booking, you can add on the exciting stuff like sightseeing activities. Our travel packages make it easy to customize an unforgettable South Main holiday.
What should I know before booking a South Main travel package?
You can save big by bundling your hotels, airfares and rental cars. Once you've made your booking, you can add on things like sightseeing tours or experiences. Your next unforgettable adventure is only a couple of clicks away.
Can I choose my airline with a South Main Expedia holiday package?
You certainly can. Expedia has access to more than 550 airline partners around the world, so fly with the carrier that best suits your needs.
If I'm not able to travel, can I cancel my South Main holiday package?
It's hard to predict what the future holds, so it's comforting to know that you can change or cancel your South Main holiday package. If you made your booking in the last 24 hours, you may be entitled to a refund. If it's an older booking, your airline, hotel or car rental company may charge a fee. Visit our Customer Service Portal to learn more.
Things to do
Houston Museum of Natural Sciences: Planetarium Ticket
€10
per adult
80% of travellers recommend
Houston's Official City & Mural Tour!
€35
per adult
88% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
€13
per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.