Cape Girardeau Holidays
- Plan, book, travel with confidence
- Better togetherSave up to €900 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top hotels in Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is €96 per night from 20 May to 21 May
€96
20 May - 21 May
includes taxes & fees
9.6/10 Exceptional! (1,011 reviews)
Was a great stay!
Reviewed on 11 May 2026
The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is €127 per night from 14 May to 15 May
€127
14 May - 15 May
includes taxes & fees
9.4/10 Exceptional! (566 reviews)
I love these hotel rooms because they’re very spacious, bright and clean!
Reviewed on 9 May 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
433 CAPE WEST CROSSINGS Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is €89 per night from 31 May to 1 Jun
€89
31 May - 1 Jun
includes taxes & fees
9.4/10 Exceptional! (182 reviews)
The hotel room was very clean and the beds were comfortable, which made for a good night’s sleep. The staff was friendly and the overall stay was pleasant. The only downside was the breakfast. The food selection was limited and the quality was disappointing. Other than breakfast, the hotel experience ...
Reviewed on 11 May 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
eDen Spa & Salon
You can take time to visit eDen Spa & Salon during your travels to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
