Medical Center District Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €185 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
San Antonio River Walk showing a river or creek, a bridge and heritage architecture

Downtown San Antonio

4 out of top 10 points of interest in this area
4.5/5(42 area reviews)

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Find hotels in Downtown San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is €89 per night from 8 Jan to 9 Jan
€89
8 Jan - 9 Jan 2026
includes taxes & fees
8.4/10 Very Good! (3,126 reviews)
The rooms are nice, small fridge to store drinks and snacks, coffee maker, comfy bed, and the bathroom is nice and clean. The breakfast is good, easily accessible and easy to take back to your room.

Reviewed on 26 Dec 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is €111 per night from 2 Jan to 3 Jan
€111
2 Jan - 3 Jan 2026
includes taxes & fees
8.6/10 Excellent! (1,004 reviews)
No toilet paper

Reviewed on 27 Dec 2025

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
The price is €89 per night from 9 Jan to 10 Jan
€89
9 Jan - 10 Jan 2026
includes taxes & fees
8.6/10 Excellent! (1,002 reviews)
The bed was great! That’s the important thing. Staff was great as well. The in-house Starbucks is good but limited - all in all a great value for the money. Whenever I’m in San Antonio, I will I’ll stay there.

Reviewed on 21 Dec 2025

Courtyard by Marriott Medical Center San Antonio
See all 4,732 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Medical Centre District holiday package cost?
Starting from just , a holiday package is your passport to low-priced travel. Create your own Medical Centre District adventure by picking from our huge range of airfares, hotels and rental cars.
How do I get a cheap travel package to Medical Centre District?
It's as simple as bundling. Hotels, rental cars and flights — combine whatever you need into a Medical Centre District holiday package and save. Score even better deals when you include extras such as activities or tours to your booking. But that's not the only good part. You have the freedom to customize your holiday your own way. We offer over 550 airlines and 1,000,000 properties throughout the world, so that everyone has a chance to travel and fulfil those holiday dreams.
Where should I stay in Medical Centre District?
Make a reservation just around the corner from Six Flags Fiesta Texas, one of this area's most well-known attractions. It's the ideal spot for serious sightseers.
What are the top hotels in Medical Centre District?
Amazing, Contemporary, Beautiful and Fairfield Inn & Suites by Marriott San Antonio Medical Centre are two of the most well-known hotels in Medical Centre District. Why not take a look at the amenities and rates at each and then make up your mind?
How far in advance should I book my Medical Centre District holiday?
It all depends on the airline, but it's usually possible to look up international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers will sometimes nab a cheaper ticket just weeks before the date of departure.
What does an Expedia Medical Centre District travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it easy to customize an exciting Medical Centre District holiday.
What should I know before booking a Medical Centre District travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fantastic discounts. You're not limited to hotels, however. Book with us and select from island resorts, city apartments and just about everything in between!
Can I choose my airline with a Medical Centre District Expedia holiday package?
Yes, you're in charge. We have access to over 550 partner airlines globally, so you can tailor your Medical Centre District trip according to your budget and travel needs.
If I'm not able to travel, can I cancel my Medical Centre District holiday package?
Whether it's your hotel or flight, you can cancel or change it. Booked your Medical Centre District holiday package in the last 24 hours? You may be able to make any changes for free. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For more information, head to our Customer Service Portal. We're here to help you every step of the way.

Popular places to visit

USAA Corporate Office Headquarters

USAA Corporate Office Headquarters is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Stroll along the riverfront or attend a sporting event in this family-friendly area.

USAA Corporate Office Headquarters

Things to do

SEA LIFE San Antonio

SEA LIFE San Antonio

€21
per adult
78% of travellers recommend
SEA LIFE San Antonio
San Antonio Zoo Any Day Ticket including ZooLights

San Antonio Zoo Any Day Ticket including ZooLights

€25
per adult
96% of travellers recommend
San Antonio Zoo Any Day Ticket including ZooLights
San Antonio: Witte Museum Admission Ticket

San Antonio: Witte Museum Admission Ticket

€14
per adult
84% of travellers recommend
San Antonio: Witte Museum Admission Ticket
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.