Medical Center District

San Antonio

Photo by Linda Cronan

Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is €90 per night from 6 Jan to 7 Jan
€90
6 Jan - 7 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,144 reviews)
Clean room and nice staff

Reviewed on 1 Jan 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is €111 per night from 16 Jan to 17 Jan
€111
16 Jan - 17 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.4/10 Very Good! (1,013 reviews)
It was a great stay nothing to complain about. Liked the service, cleanliness.

Reviewed on 29 Dec 2025

San Antonio Marriott Northwest Medical Center
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is €127 per night from 12 Jan to 13 Jan
€127
12 Jan - 13 Jan
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (2,304 reviews)
We ate small meals outside the hotel, we self parked at Holday Inn. We only stayed 3 days due to my wife not feeling well. The hotel was very accommodating. My only suggestion is installing hand rails in showers. Us older people always afraid of slipping in the showers..Thank you very much..

Reviewed on 30 Dec 2025

Hotel Valencia Riverwalk
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
The price is €107 per night from 26 Jan to 27 Jan
€107
26 Jan - 27 Jan
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and 2 hot tubs. Our guests praise the pool and the helpful staff in their reviews. ...
8.8/10 Excellent! (1,334 reviews)
A lot of activities, including basketball/pickleball court. Pool and lazy river were heated and we could use them even with a bit cooler weather. Very relaxing atmosphere! True vacations

Reviewed on 2 Jan 2026

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
The price is €91 per night from 14 Jan to 15 Jan
€91
14 Jan - 15 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (3,810 reviews)
Trying to have breakfast after New Years eve festivities was almost impossible. Even though the breakfast are seems large, it does not fit the number of guests at that time.Even the elevators are jammed packed. Inconvenience, but understandable.

Reviewed on 2 Jan 2026

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the ...
8/10 Very Good! (6,295 reviews)
Quick Check In, Clean Room

Reviewed on 5 Jan 2026

Riverwalk Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

Northwest Side
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Shearer Hills - Ridgeview

While visiting Shearer Hills - Ridgeview, you might make a stop by sights like North Star Mall and San Pedro Driving Range & Par 3 Course.

Shearer Hills - Ridgeview
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio River or The DoSeum while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

Tobin Hill might not have many top sights, but San Antonio River and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
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Uptown

If you're spending some time in Uptown, San Antonio River and Marion Koogler McNay Art Museum are top sights worth seeing.

Uptown


Medical Center District

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