Medical Center District

San Antonio

Photo by Linda Cronan
Photo by Linda Cronan

Popular places to visit

USAA Corporate Office Headquarters

USAA Corporate Office Headquarters is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Stroll along the riverfront or attend a sporting event in this family-friendly area.

USAA Corporate Office Headquarters

South Texas Medical Center

If South Texas Medical Center is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

South Texas Medical Center

University of Texas Health and Science Center at San Antonio

If University of Texas Health and Science Center at San Antonio is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

University of Texas Health and Science Center at San Antonio

University Hospital - University Health System

If University Hospital - University Health System is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

University Hospital - University Health System

CHRISTUS Santa Rosa Hospital - Medical Center

If CHRISTUS Santa Rosa Hospital - Medical Center is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

CHRISTUS Santa Rosa Hospital - Medical Center

Methodist Healthcare

If Methodist Healthcare is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

Methodist Healthcare

Things to do

San Antonio: Discovery Tour at Natural Bridge Caverns

San Antonio: Discovery Tour at Natural Bridge Caverns

€31
per adult
92% of travellers recommend
San Antonio: Discovery Tour at Natural Bridge Caverns
SEA LIFE San Antonio

SEA LIFE San Antonio

€22
per adult
78% of travellers recommend
SEA LIFE San Antonio
San Antonio: Tower of the Americas Entry Ticket

San Antonio: Tower of the Americas Entry Ticket

€18
per adult
San Antonio: Tower of the Americas Entry Ticket
Best of San Antonio Tour

Best of San Antonio Tour

€142
per adult
94% of travellers recommend
Best of San Antonio Tour
San Antonio: San Antonio Zoo Any Day Ticket

San Antonio: San Antonio Zoo Any Day Ticket

€26
per adult
94% of travellers recommend
San Antonio: San Antonio Zoo Any Day Ticket
San Antonio: Witte Museum Admission Ticket

San Antonio: Witte Museum Admission Ticket

€15
per adult
74% of travellers recommend
San Antonio: Witte Museum Admission Ticket
See all activities in San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
The price is €90 per night from 23 Aug to 24 Aug
€90
23 Aug - 24 Aug
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,876 reviews)
"All the staff was really nice and had lots of trees for shade when u just wanted some fresh air. Breakfast options were great and tasty 😋"

Reviewed on 20 Aug 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is €91 per night from 31 Aug to 1 Sept
€91
31 Aug - 1 Sept
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,008 reviews)
"Hotel is up to date. Clean Well maintained Huge Bar and dining area"

Reviewed on 18 Aug 2025

San Antonio Marriott Northwest Medical Center
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is €92 per night from 31 Aug to 1 Sept
€92
31 Aug - 1 Sept
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (983 reviews)
"Eveyrhing excelent the staff great they give us a great welcome and the hotel is in excellent condition"

Reviewed on 18 Aug 2025

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
The price is €99 per night from 4 Sept to 5 Sept
€99
4 Sept - 5 Sept
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,003 reviews)
"The stay was great overall. The only issue was the elevator was out."

Reviewed on 14 Aug 2025

Courtyard by Marriott Medical Center San Antonio
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive, San Antonio, TX
The price is €133 per night from 2 Sept to 3 Sept
€133
2 Sept - 3 Sept
includes taxes & fees
Stay at this 3.5-star family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and a lazy river. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (1,007 reviews)
Always enjoy the water activities
"Same fun waterslides, pool & lazy river. Disappointed there were no lifeguards. Usually multiple guards watching inside & outside pool area. Biggest disappointment on thursday 8/14 neither of the waterside bars/beverage hus were open. When it's 100 degrees out you really need a cup of ice & water. ..."

Reviewed on 21 Aug 2025

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (5,716 reviews)
Great stay and will be back
"The room was amazing as usual!"

Reviewed on 19 Aug 2025

Get rates
Riverwalk Plaza
See all 4,580 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Los Angeles Heights

While Northwest Los Angeles Heights may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Alamo and Alamodome.

Northwest Los Angeles Heights
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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

Northwest Side
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by The DoSeum or San Antonio Zoo and Aquarium while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

While visiting Tobin Hill, you might make a stop by sights like San Antonio River and Temple Beth-El.

Tobin Hill
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Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

Uptown

Medical Center District

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