Medical Center District

San Antonio

A cityscape with a prominent tower, a large body of water, and a sunset.
A canal with colorful umbrellas and trees along the banks.
A riverside café with colorful umbrellas and tables.
A tranquil waterway flanked by lush greenery and stone pathways.
A canal with a boat, surrounded by lush greenery and a stone bridge.

Stay near popular Medical Center District attractions

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is €92 per night from 6 Jul to 7 Jul
€92
6 Jul - 7 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very good! (3,455 reviews)
"It was a great stay. The front desk was welcoming and helpful. The bedroom was a decent size. The location seemed to be safe."

Reviewed on 5 Jul 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is €121 per night from 12 Jul to 13 Jul
€121
12 Jul - 13 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy room service, a 24-hour fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (1,099 reviews)
"Clean, spacious room, courteous staff. Great stay!"

Reviewed on 5 Jul 2026

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
The price is €93 per night from 12 Jul to 13 Jul
€93
12 Jul - 13 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,374 reviews)
"Our stay was absolutely wonderful."

Reviewed on 5 Jul 2026

Drury Inn & Suites San Antonio Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
The price is €92 per night from 11 Jul to 12 Jul
€92
11 Jul - 12 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,008 reviews)
"A well-maintained interior property, building exterior is a little rough. Staff was very helpful and the property is secured. Enjoyed the stay."

Reviewed on 4 Jul 2026

Courtyard by Marriott Medical Center San Antonio
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is €133 per night from 21 Jul to 22 Jul
€133
21 Jul - 22 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (4,850 reviews)
"Very comfortable"

Reviewed on 5 Jul 2026

Drury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
The price is €92 per night from 6 Jul to 7 Jul
€92
6 Jul - 7 Jul
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very good! (6,458 reviews)
"Had to ask 2 or 3 times to get anything (e.g., towels, etc.). All gym equipment didn't work. Room's bathroom doesn't even have a door, just a sliding piece of wood."

Reviewed on 5 Jul 2026

Riverwalk Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District

Downtown San Antonio

A scenic riverfront great entertainment and top sights from San Antonio River to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and San Antonio River are top sights worth seeing.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Stone Ridge Market and Shops at Hardy Oak while you're in town.



Medical Center District

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