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San Antonio Hotel Guide. Hotels in Medical Center District, San Antonio, United States of America

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Check prices for these dates

This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

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Our top choices for Medical Center District hotels

A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.

1. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
Medical Center District
9.0 out of 10, Wonderful, (1,069 reviews)
"We were so comfy staying!"
United States
Maisa
The price is €87
includes taxes & fees
8 Sept - 9 Sept
Fairfield Inn & Suites by Marriott San Antonio Medical Center
A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

2. Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,001 reviews)
"Excellent hotel and stay. The breakfast is really good and the staff is always incredible. Never disappoints!"
United States
Daniel
The price is €91
includes taxes & fees
18 Sept - 19 Sept
Courtyard by Marriott Medical Center San Antonio
A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

3. Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,439 reviews)
"Amazaing stay friendly staff!"
United States
Melissa
The price is €92
includes taxes & fees
8 Sept - 9 Sept
Drury Inn & Suites San Antonio Northwest Medical Center
A modern kitchen with a large window, wooden counter, and two bar stools.

4. Park Inn by Radisson, Medical Center

Park Inn by Radisson, Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (1,001 reviews)
"The staff was very friendly, check in and out was fast and the ease of getting to food and our appointments was great."
United States
Amanda
The price is €63
includes taxes & fees
10 Sept - 11 Sept
Park Inn by Radisson, Medical Center
A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.

5. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3,616 reviews)
"Great location and very clean/nice."
United States
Melissa
The price is €90
includes taxes & fees
7 Sept - 8 Sept
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
A spacious lobby with a central staircase, seating area, and large windows.

6. San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,164 reviews)
"Great hotel"
United States
Mario
The price is €81
includes taxes & fees
4 Oct - 5 Oct
San Antonio Marriott Northwest Medical Center
A building entrance with a glass door, a Pepsi vending machine, and a yellow bollard.

7. OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.4 out of 10, Good, (247 reviews)
"It was quiet and clean and the staff was very friendly"
United States
Ronnie
The price is €56
includes taxes & fees
28 Sept - 29 Sept
OYO Inn & Suites Medical Center San Antonio
A gas station with a sign for 'Atria Inn & Suites' and a 'Clearance - 12' sign.

8. Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.4 out of 10, Good, (313 reviews)
"Amazing comfortable and affordable"
United States
José
The price is €58
includes taxes & fees
5 Oct - 6 Oct
Atria Inn & Suites
A modern bedroom with a large bed, bedside tables, a desk, and a chair.

9. Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (1,000 reviews)
"front desk reps very friendly and helpful"
United States
Rachel
The price is €54
includes taxes & fees
16 Sept - 17 Sept
Motel 6 San Antonio, TX - Northwest Medical Center
A hotel room with two beds, a desk, a chair, a mirror, and a bathroom.

10. Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (365 reviews)
"It's a good place to stay I"
United States
Ruben
The price is €47
includes taxes & fees
4 Oct - 5 Oct
Studio 6 San Antonio, Tx - Northwest Medical Center
A hotel room with a large bed, a desk with a chair, a television on a stand, and a mirror on the wall.

11. Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.2 out of 10, (569 reviews)
"Yes I would stay again"
United States
Jasper
The price is €38
includes taxes & fees
6 Sept - 7 Sept
Flex Studios
A hotel room with two beds, a TV, a desk, and a kitchenette in the background.

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.8 out of 10, (989 reviews)
"Good for a short stay traveling through the SA area."
United States
Jerron
Studio 6 Extended Stay - San Antonio, TX - Medical Center
A modern hotel with a prominent signage for Springhill Suites by Marriott, featuring a multi-story structure with a flat roof and a covered entrance area.

13. SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW
3.0 star property
2.7 km from Medical Center District
8.8 out of 10, Excellent, (1,007 reviews)
"Good hotel close to interstate. Clean hotel overall. Would probably stay here again."
United States
Erick
The price is €103
includes taxes & fees
18 Sept - 19 Sept
SpringHill Suites by Marriott San Antonio Medical Center/NW
A modern bar area with a central island, bar stools, and a kitchen counter with appliances.

14. Hyatt Place San Antonio-Northwest/Medical Center

Hyatt Place San Antonio-Northwest/Medical Center
3.0 star property
3.7 km from Medical Center District
8.4 out of 10, Very good, (1,039 reviews)
"Great stay Great staff , clean room and bathroom comfy bed Great breakfast"
United States
Monty
The price is €96
includes taxes & fees
21 Sept - 22 Sept
Hyatt Place San Antonio-Northwest/Medical Center
A spacious dining area with multiple tables and chairs, a bar area, and a television mounted on the wall.

15. Hampton Inn & Suites San Antonio Northwest/Medical Center

Hampton Inn & Suites San Antonio Northwest/Medical Center
2.5 star property
Northwest Side, 4.7 km from Medical Center District
8.4 out of 10, Very good, (1,048 reviews)
"Solid property… friendly staff, and great for an overnight business trip"
United States
James
The price is €84
includes taxes & fees
13 Sept - 14 Sept
Hampton Inn & Suites San Antonio Northwest/Medical Center
A hotel with a modern design, featuring a covered parking area and multiple parking spaces.

16. Best Western Medical Center North Inn & Suites Near Six Flags

Best Western Medical Center North Inn & Suites Near Six Flags
2.5 star property
Northwest Side, 5.2 km from Medical Center District
8.2 out of 10, Very good, (1,598 reviews)
"Amazing place to stay."
United States
Shelby
The price is €67
includes taxes & fees
10 Sept - 11 Sept
Best Western Medical Center North Inn & Suites Near Six Flags
An indoor swimming pool with a hot tub, tiled flooring, and a seating area with tables and chairs.

17. Drury Inn & Suites Near La Cantera Parkway

Drury Inn & Suites Near La Cantera Parkway
3.0 star property
La Cantera District, 9.5 km from Medical Center District
9.4 out of 10, Exceptional, (1,951 reviews)
"Clean room - Great staff -Good breakfast"
United States
Norma
The price is €96
includes taxes & fees
13 Sept - 14 Sept
Drury Inn & Suites Near La Cantera Parkway
A hotel pool area with lounge chairs and a building with large windows in the background.

18. The Westin San Antonio North

The Westin San Antonio North
4.0 star property
3.4 km from Medical Center District
8.4 out of 10, Very good, (1,596 reviews)
"Very nice property"
United States
Noemi
The price is €97
includes taxes & fees
7 Sept - 8 Sept
The Westin San Antonio North
A spacious lobby with a modern design, featuring a large seating area with sofas and armchairs, a patterned rug, and a reception desk.

19. Comfort Inn and Suites Near Medical Center

Comfort Inn and Suites Near Medical Center
2.5 star property
4.6 km from Medical Center District
7.2 out of 10, Good, (2,245 reviews)
"They had clean rooms great staff. They also had a decent pool"
United States
Giovanni
The price is €56
includes taxes & fees
10 Sept - 11 Sept
Comfort Inn and Suites Near Medical Center
A poolside area with lounge chairs and a metal railing.

20. Holiday Inn Express San Antonio-Airport by IHG

Holiday Inn Express San Antonio-Airport by IHG
2.5 star property
8.9 km from Medical Center District
9.4 out of 10, Exceptional, (1,003 reviews)
"Great stay. Perfect location, amazing breakfast"
United States
Xiloneen
The price is €99
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express San Antonio-Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Medical Center District

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.
Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
9.2
Wonderful
1,439 reviews
View
A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,069 reviews
View
A modern bar area with wooden bar counters, black bar stools, and pendant lighting.
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,001 reviews
View
A spacious lobby with a central staircase, seating area, and large windows.
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,164 reviews
View
A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very good
3,616 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

A large, abstract sculpture with a flowing design, set against a dramatic sky.
Photo by Sarah C.
Open Photo by Sarah C.

Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Dub Farris Athletic Complex are top sights worth seeing.

A field of bluebonnets under a vibrant sunset sky.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

Top Medical Center District Hotel Reviews

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

10/10 Excellent
"Very good"
Erica 1-night trip
Posted 9 hours ago
Drury Plaza Hotel San Antonio Riverwalk

Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Consider a visit to Cinemark San Antonio 16 as part of your Medical Center District travel plans.
What's a favourite hotel to stay in Medical Center District?
Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Courtyard by Marriott Medical Center San Antonio and San Antonio Marriott Northwest Medical Center.
How many hotels will I be able to find in Medical Center District?
Expedia has 123 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
Cinemark San Antonio 16 is an attraction you might want to check out while you're in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

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