Alton Hotel Guide - OSF Saint Anthony's Health Center hotels in Alton, United States of America.

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for OSF Saint Anthony's Health Center hotels

Free daily buffet breakfast
Holiday Inn Express and Suites Alton St Louis Area by IHG

Holiday Inn Express and Suites Alton St Louis Area by IHG

Holiday Inn Express and Suites Alton St Louis Area by IHG
2.5 star property
1.5 km from OSF Saint Anthony's Health Center
9.2 out of 10, Wonderful, (163)
"Staff and location were perfect"
United States
Ileta
The price is €114
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express and Suites Alton St Louis Area by IHG
Exterior
Hampton Inn & Suites St. Louis/Alton

Hampton Inn & Suites St. Louis/Alton

Hampton Inn & Suites St. Louis/Alton
2.5 star property
1.5 km from OSF Saint Anthony's Health Center
9.0 out of 10, Wonderful, (644)
"The staff were very professional and friendly. The breakfast had a great selection."
United States
Melissa
The price is €110
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn & Suites St. Louis/Alton
Exterior
Best Western Plus Parkway Hotel

Best Western Plus Parkway Hotel

Best Western Plus Parkway Hotel
2.5 star property
1.5 km from OSF Saint Anthony's Health Center
8.2 out of 10, Very good, (1000)
"Staff was excellent when checking in"
United States
larry
The price is €74
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Parkway Hotel
Desk, iron/ironing board, free WiFi, bed sheets
Super 8 by Wyndham Alton

Super 8 by Wyndham Alton

Super 8 by Wyndham Alton
2.0 star property
1.4 km from OSF Saint Anthony's Health Center
7.0 out of 10, Good, (872)
"The place was clean and plenty of room for our boat"
United States
David
The price is €87
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Alton
Lobby
Comfort Inn Alton near I-255

Comfort Inn Alton near I-255

Comfort Inn Alton near I-255
2.5 star property
3.5 km from OSF Saint Anthony's Health Center
7.6 out of 10, Good, (505)
"Perfect accommodations for a brief overnight stay. "
United States
Steffany
The price is €77
includes taxes & fees
25 Jan - 26 Jan 2026
Comfort Inn Alton near I-255
Lobby
The Great Rivers, an Ascend Collection Hotel

The Great Rivers, an Ascend Collection Hotel

The Great Rivers, an Ascend Collection Hotel
3.0 star property
3.7 km from OSF Saint Anthony's Health Center
7.8 out of 10, Good, (760)
"The hotel is being remodeled, so it's hard to give it a fair review."
United States
Stephen
The price is €81
includes taxes & fees
25 Jan - 26 Jan 2026
The Great Rivers, an Ascend Collection Hotel
Exterior
Budget Motel Granite City/St Louis Area

Budget Motel Granite City/St Louis Area

Budget Motel Granite City/St Louis Area
2.0 star property
16.8 km from OSF Saint Anthony's Health Center
6.4 out of 10, (15)
"Its nice here"
United States
Sheila
The price is €62
includes taxes & fees
7 Jan - 8 Jan 2026
Budget Motel Granite City/St Louis Area
Premium bedding, pillow-top beds, blackout curtains, iron/ironing board
Econo Lodge Inn & Suites Granite City - St. Louis

Econo Lodge Inn & Suites Granite City - St. Louis

Econo Lodge Inn & Suites Granite City - St. Louis
2.0 star property
16.8 km from OSF Saint Anthony's Health Center
6.2 out of 10, (246)
"Overall the stay was adequate, right off the highway so convenient."
United States
Henry
The price is €65
includes taxes & fees
1 Jan - 2 Jan 2026
Econo Lodge Inn & Suites Granite City - St. Louis
Lobby
Days Inn by Wyndham Pontoon Beach

Days Inn by Wyndham Pontoon Beach

Days Inn by Wyndham Pontoon Beach
2.0 star property
19.8 km from OSF Saint Anthony's Health Center
6.2 out of 10, (571)
"Bed was soooooooo comfortable and front desk guy that checked me in was great as well "
United States
Maurice
The price is €61
includes taxes & fees
25 Jan - 26 Jan 2026
Days Inn by Wyndham Pontoon Beach
Exterior
Bel Air Motel

Bel Air Motel

Bel Air Motel
3.5 star property
7.9 km from OSF Saint Anthony's Health Center
8.6 out of 10, Excellent, (196)
"Great place super clean. Only thing missing no coffee and our room could have had a nice bistro table to sit at"
United States
James
The price is €82
includes taxes & fees
25 Jan - 26 Jan 2026
Bel Air Motel
Front of property
The Green Tree Inn

The Green Tree Inn

The Green Tree Inn
3.0 star property
17.1 km from OSF Saint Anthony's Health Center
9.4 out of 10, Exceptional, (209)
"Amazing place. "
United States
janet
The price is €178
includes taxes & fees
1 Jan - 2 Jan 2026
The Green Tree Inn
Blackout curtains, free WiFi, bed sheets
Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach
2.5 star property
18.7 km from OSF Saint Anthony's Health Center
7.8 out of 10, Good, (577)
"Yes, very good, yes good breakfast, yes truck parking."
United States
mark
The price is €56
includes taxes & fees
31 Dec - 1 Jan 2026
Red Lion Inn & Suites Pontoon Beach
Lobby lounge
Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City

Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City

Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City
2.5 star property
19.4 km from OSF Saint Anthony's Health Center
9.2 out of 10, Wonderful, (488)
"This hotel was well kept,the breakfast was excellent. Stsff was friendly. "
United States
Dennis M
The price is €105
includes taxes & fees
26 Jan - 27 Jan 2026
Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top OSF Saint Anthony's Health Center Hotel Reviews

Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

10/10 Excellent
"Clean rooms and friendly, accommodating staff. "
Tamah 1-night trip
Posted 2 days ago
Renaissance St. Louis Airport Hotel

Hotels near other OSF Saint Anthony's Health Center attractions

Doorman Square Park

After visiting Doorman Square Park, make a plan to see the other sights and activities in Alton. Visit the shops in this family-friendly area or simply enjoy its restaurants.
See properties

Alton Square Mall

3.8/5 (11 reviews)
You can browse for the perfect souvenirs at Alton Square Mall during your visit to Alton. Visit the shops in this family-friendly area or simply enjoy its restaurants.
See properties

Frequently asked questions

What's the area like around OSF Saint Anthony's Health Center?
OSF Saint Anthony's Health Center is located in Alton. Travellers like this family-friendly area for its restaurants and shopping. If you're looking for a convenient place to stay, take a look at the 8 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay close to OSF Saint Anthony's Health Center?
Hilton St. Louis Airport is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and a 24-hour fitness centre. You'll find it 15.5 mi (24.9 km) from OSF Saint Anthony's Health Center. Other good options around the area include La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North and Renaissance St. Louis Airport Hotel.
How many hotels will I find near OSF Saint Anthony's Health Center?
Expedia has 8 hotels and other accommodation options within a mile from OSF Saint Anthony's Health Center.
If I need to cancel the hotel reservation for my stay near OSF Saint Anthony's Health Center, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within 24 hours of booking. Add your dates and click on "Search", then filter by "fully refundable" to view the best deals available near OSF Saint Anthony's Health Center.
What can I see and do near OSF Saint Anthony's Health Center?
You'll want to browse the collections at Historic Museum of Torture Devices, Alton Prison and National Great Rivers Museum. At Ellis Island, John M Olin Nature Preserve and Spatterdock Lake, take some time to really appreciate nature. A shopping trip to Alton Square Mall, Fast Eddie's Bon Air or Mineral Springs Mall might be the perfect place to find that souvenir you've been looking for.