Otay Mesa West Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €185 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
Default Image

Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa West

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is €153 per night from 29 Dec to 30 Dec
€153
29 Dec - 30 Dec
includes taxes & fees
8.2/10 Very Good! (3,167 reviews)
Definitely the best hotel I’ve stayed at in San Diego. Nice walk around the marina in the mornings. Coffee was pretty good. No complaints. It’s also walkable from the airport.

Reviewed on 24 Dec 2025

Sheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is €113 per night from 4 Jan to 5 Jan
€113
4 Jan - 5 Jan 2026
includes taxes & fees
9/10 Wonderful! (3,213 reviews)
Good room, hotel staff, amenities.

Reviewed on 25 Dec 2025

Bay Club Hotel & Marina
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is €102 per night from 4 Jan to 5 Jan
€102
4 Jan - 5 Jan 2026
includes taxes & fees
8.8/10 Excellent! (789 reviews)
Staff were super accommodating and welcoming, Melodia made every breakfast feel like home with her warm and kind energy

Reviewed on 24 Dec 2025

The DEXTRO Little Italy, BW Premier Collection
See all 6,860 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa West holiday package cost?
Discover the best of Otay Mesa West from as little as . Choose from a wonderful selection of flights, hotels and rental cars to suit every style and budget. You can score even better deals when you add some experiences or tours to your package.
How do I get a cheap travel package to Otay Mesa West?
Booking an Otay Mesa West holiday package with Expedia is the easiest way to save. We have over 550 partner airlines and 1,000,000 properties across the globe. With such an awesome range to select from, you'll have no trouble putting together your next dream holiday.
Where should I stay in Otay Mesa West?
You'll want to stay where the action is. Many people book hotels around popular attractions, like Las Americas Premium Outlets, North Island Credit Union Amphitheatre and Aquatica.
How far in advance should I book my Otay Mesa West holiday?
Smart travellers will likely want to book early. You can normally start comparing international fares on Expedia up to a year before your intended flight. If you're booking last minute, don't despair. Low prices sometimes appear just weeks before departure dates.
What does an Expedia Otay Mesa West travel package include?
It all depends on what type of getaway you're contemplating. Otay Mesa West holiday deals can include hotels, car rentals and flights. You can mix and match to find the travel package that fits your needs. You can also add on experiences and activities after you've booked to score even bigger discounts.
What should I know before booking an Otay Mesa West travel package?
Get ready to save with an Expedia travel package. Bundle your airfares, rental cars and hotels and pick up fabulous discounts. You're not limited to hotels, though. Book with us and select from beach villas, mountain cabins and everything in between!
Can I choose my airline with an Otay Mesa West Expedia holiday package?
With a holiday package, you're the boss. Whether you'd like to fly to Otay Mesa West in economy or business class, simply pick from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Otay Mesa West holiday package?
You can. We get that even the best-laid plans can go awry, so we're here to help if you need to make changes to your Otay Mesa West holiday package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may impose a fee if you booked more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.

Popular places to visit

San Diego Zoo showing a pond, landscape views and zoo animals

San Diego Zoo

4.5/5(47 reviews)

Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.

San Diego Zoo
Mission Bay which includes a sandy beach

Mission Bay

4.5/5(31 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Balboa Park

Balboa Park

4.5/5(80 reviews)

This huge city-centre park is home to a range of fantastic cultural institutions, and it’s also a lovely place for a walk.

Balboa Park

Things to do

Whaley House Museum Day Tour

Whaley House Museum Day Tour

€12
per adult
94% of travellers recommend
Whaley House Museum Day Tour
San Diego: Luggage Storage in Marina

San Diego: Luggage Storage in Marina

€8
per adult
80% of travellers recommend
San Diego: Luggage Storage in Marina
Small-Group Sunset Sailing Experience on San Diego Bay

Sunset Sail Along the San Diego Skyline

€76
per adult
98% of travellers recommend
Sunset Sail Along the San Diego Skyline
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.