Visit Otay Mesa West
Popular places to visit
San Diego Zoo
Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
Enjoy the old-world charm of this seaside suburb where the beautiful people live, close to central San Diego.
SeaWorld
Beautiful sea creatures, exhilarating rides and fun and educational displays – this marine park is a treat for all the family.
Things to do
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
Crossing Borders: Tijuana Day Trip from San Diego
San Diego Sunset Cruise from Mission Bay
San Diego Padres Baseball Game at Petco Park
Taste of Little Italy in San Diego
Top hotels in Otay Mesa West
Handlery Hotel
Reviewed on 19 Jul 2025
Wyndham San Diego Bayside
Reviewed on 18 Jul 2025
Manchester Grand Hyatt San Diego
Reviewed on 21 Jul 2025
The Dana on Mission Bay
Reviewed on 21 Jul 2025
Marriott Marquis San Diego Marina
Reviewed on 19 Jul 2025
The Dextro Hotel, BW Premier Collection
Reviewed on 20 Jul 2025
Other neighbourhoods around Otay Mesa West
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Point Loma
Seaside views a bustling port and top sights from Shelter Island to Humphreys Concerts by the Bay – discover Point Loma, a destination also famous for its island views.