
Panama City Holidays
- Plan, book, travel with confidence
Better together
Save up to €185 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Where to stay in Panama City
Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City

Casco Viejo
3.5/5(3 area reviews)
Unique features of Casco Viejo include the historical sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.
Top hotels in Panama City

Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is €111 per night from 8 Aug to 9 Aug
€111
8 Aug - 9 Aug
includes taxes & fees
9/10 Wonderful! (4,150 reviews)
"All staffs were friendly,pleasant and helpful. rooms were clean and the AC was fresh and not musty. The pool was relaxing the entire ambiance was amazing. I didn’t eat much at the hotel cause I was more excited about trying off site places. But overall the property was amazing."
Reviewed on 29 Jul 2025

Sheraton Grand Panama
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is €128 per night from 10 Aug to 11 Aug
€128
10 Aug - 11 Aug
includes taxes & fees
8.4/10 Very Good! (910 reviews)
"Me and my husband loved staying there! Superb hotel beyond international standards! The staff was so friendly and attentive. The hotel is gorgeous! The pool is amazing and so is the spa. The breakfast buffet is excellent. I only have the best words to describe this place! I hope to stay there when ..."
Reviewed on 26 Jul 2025

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is €87 per night from 10 Aug to 11 Aug
€87
10 Aug - 11 Aug
includes taxes & fees
7.6/10 Good! (1,011 reviews)
"We had a great time! Everyone was very friendly, even with the language barrier (our fault, of course). The only complaint I have is the water pressure in our room’s bathroom/shower. It wasn’t really great, but a minor issue since the room was exactly as described/pictured. Thank you for having ..."
Reviewed on 29 Jul 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
What to do in Panama City

Day Tour in San Blas Islands All Included Visiting 4 Islands
€128
per adult
94% of travellers recommend

Panama City: Poin Glass Observation Deck Ticket with VR Tour
€28
per adult
100% of travellers recommend
Frequently asked questions
More trip options
Expedia's Latest Trends
Hotels
- Denia Marriott La Sella Golf Resort & Spa
- B&B Glasson
- Apartments Grenada
- Hotels in Galway City Centre
- B&B Achill Island
- 5 Star Hotels in Grand Canal Dock
- Hotels in Belfast
- BLUESEA Interpalace
- Fernwood
- Hotels in 5th Arrondissement
- Sugar Bay Barbados - All Inclusive
- The St. Regis Abu Dhabi
- Apartments Werl
- Hotels in City of Westminster
- 4 Star Hotels in Allihies
Flights
- Flights from Cork (ORK) to Warsaw (WAW)
- Flights from Dubai (DXB) to London (LHR)
- Qatar Airways Velika Gorica (ZAG) to Kathmandu (KTM) flights
- Flights from Zanzibar Town (ZNZ) to Serengeti (SEU)
- Flights from Palma de Mallorca (PMI) to Málaga (AGP)
- Flights from Chicago (ORD) to Florence (CVG)
- Flights to Sabadell
Packages
Holiday Rentals
General
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.