Photo by Mike McClain

Puxico Hotels

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Check prices for these dates

Tonight
9 Dec - 10 Dec
Tomorrow
10 Dec - 11 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Puxico hotels

Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (697)
"Amazing place"
United States
Mladen
The price is €102
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Poplar Bluff by IHG
Seasonal outdoor pool, open 10:00 AM to 9:00 PM, pool umbrellas
Dexter Inn

Dexter Inn

2.5 star property
Dexter
7.0 out of 10, Good, (332)
"Room was nice and spacious."
United States
Rebecca
The price is €63
includes taxes & fees
10 Dec - 11 Dec
Dexter Inn
In-room safe, desk, free WiFi, bed sheets
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2.0 star property
Poplar Bluff
6.6 out of 10, (622)
"The lady at the front was very nice. "
United States
Travis
The price is €56
includes taxes & fees
18 Dec - 19 Dec
Super 8 by Wyndham Poplar Bluff Missouri
Terrace/patio
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is €95
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Poplar Bluff
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (959)
"Nice room helpful staff. "
United States
Deborah
The price is €91
includes taxes & fees
13 Dec - 14 Dec
Drury Inn & Suites Poplar Bluff
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (852)
"Very clean, great check in"
United States
Teresa
The price is €101
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Desk, iron/ironing board, free WiFi, bed sheets
Econo Lodge Dexter

Econo Lodge Dexter

2.0 star property
Dexter
6.8 out of 10, (250)
"The stay was very nice. Animal friendly, staff is super nice and house keeping is very respectful. I appreciate everyone. "
United States
Michelle
The price is €57
includes taxes & fees
7 Jan - 8 Jan 2026
Econo Lodge Dexter
Lobby
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1001)
"Love the updated rooms and the vending area."
United States
Kathi
The price is €69
includes taxes & fees
9 Jan - 10 Jan 2026
Motel 6 Poplar Bluff, MO
Lobby
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

2.5 star property
Poplar Bluff
7.8 out of 10, Good, (397)
"Good breakfast selection for the price and clean room. "
United States
Jared
The price is €87
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn Poplar Bluff North
Fountain
Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge

2.5 star property
Poplar Bluff
8.4 out of 10, Very good, (211)
"NO STAFF ON PHONE OR AT DESK. NO TOWELS! NO CUP! FILTHY COFFEE MAKER. At least the room was clean."
United States
Nicholas
Bullwinkles Rustic Lodge
Studio, 1 King Bed
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2.5 star property
Dexter
10.0 out of 10, Exceptional, (1)
"Staff was helpful and professional. The rooms were clean and comfortable "
United States
Michael
The price is €102
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn By Hilton Dexter
Deluxe Double Room
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (83)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
EC Reed's Mercantile and Hotel
Exterior
OYO Hickory House Inn

OYO Hickory House Inn

2.5 star property
Dexter
5.4 out of 10, (128)
"Nice room very comfortable bed's"
United States
Jose
The price is €48
includes taxes & fees
7 Jan - 8 Jan 2026
OYO Hickory House Inn
Front of property
Lake Wappapello

Lake Wappapello

2.0 star property
Williamsville
10.0 out of 10, Exceptional, (1)
"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."
United States
Dyann
The price is €125
includes taxes & fees
10 Dec - 11 Dec
Lake Wappapello
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Puxico

Head to sights like Mark Twain National Forest and Mingo Wilderness as you discover Puxico.

See all hotels in Puxico
Great place for sunrises, Bald Eagles in the winter, and Milkyway shots.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"Every single time I come to this location, it always exceeds my expectations. It's always clean.They always have hot coffee and they are super friendly!! Never have anything bad to say about them"
Samantha 1-night trip
Posted 6 days ago
Hampton Inn Poplar Bluff

More cheap stays in Puxico

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
The price is €69 per night from 9 Jan to 10 Jan
€69
9 Jan - 10 Jan 2026
includes taxes & fees
7.8/10 Good! (1,004 reviews)

Frequently asked questions

What's the best place for a stay in Puxico?
Motel 6 Poplar Bluff, MO, located 19.4 mi (31.3 km) from the heart of Puxico, is a top choice for your stay, based on our traveller data. Other good options for your trip to the area are Holiday Inn Poplar Bluff by IHG and Fairfield Inn & Suites by Marriott Poplar Bluff. See all available top hotels, or vacation rentals in Puxico.
What are some of the best holiday rentals that Puxico has to offer?
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff: This holiday home rental outside of Puxico offers a patio, a selection of games and a BBQ to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Puxico.
If I need to cancel my hotel reservation in Puxico, will I receive a refund?
Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.
What is staying in Puxico like?
Travellers to Puxico will find plenty to explore and enjoy. There are 53 hotels and other accommodation options in the surrounding area. Find out more about Puxico.
What is there to see in Puxico?
A couple of favourite places to visit are Mark Twain National Forest and Mingo Wilderness. You'll also find Lake Wappapello and Lake Wappapello State Park in the area. Take a look at what more there is to see and do in Expedia's Puxico guide.
What's the seasonal weather in Puxico?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Puxico is 1502 mm.

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