An aerial view of a town with industrial buildings, roads, and green areas.

St. Charles Hotels

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Check prices for these dates

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for St. Charles hotels

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

1. Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (603 reviews)
"Clean room Staff very accommodating Hot coffee and breakfast."
United States
Stanton
The price is €69
includes taxes & fees
22 Nov - 23 Nov
Spark by Hilton Rochester South
A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

2. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,004 reviews)
"Great place to stay."
United States
LeeAnn
The price is €82
includes taxes & fees
3 Dec - 4 Dec
Comfort Inn & Suites Rochester South Mayo Clinic
An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

3. Stone Mill Hotel & Suites

Stone Mill Hotel & Suites
3.0 star property
Lanesboro
9.6 out of 10, Exceptional, (729 reviews)
"Very unique property with cozy, comfortable accommodations."
United States
Bernie
The price is €101
includes taxes & fees
4 Nov - 5 Nov
Stone Mill Hotel & Suites
A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

4. Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (971 reviews)
"Nice location, staff very helpful and friendly, and nice big room"
United States
Mark
The price is €70
includes taxes & fees
28 Nov - 29 Nov
Quality Inn & Suites Mayo Clinic Area
A two-story house with a porch and a covered entryway.

5. The Wen Inn formerly Andor Wenneson

The Wen Inn formerly Andor Wenneson
3.0 star property
Peterson
9.6 out of 10, Exceptional, (100 reviews)
"Very nice stay! I look forward to staying at your place again."
United States
Daniel
The price is €99
includes taxes & fees
4 Nov - 5 Nov
The Wen Inn formerly Andor Wenneson
A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

6. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (1,001 reviews)
"The staff was extremely friendly!"
United States
Ashley
The price is €71
includes taxes & fees
4 Dec - 5 Dec
Econo Lodge Mayo Clinic Area
A modern hotel lobby with a reception desk, seating area, and a dining space.

7. Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,008 reviews)
"Nice location, easy access and good breakfast."
United States
Rick
The price is €89
includes taxes & fees
7 Nov - 8 Nov
Holiday Inn Express Rochester South - Mayo Area by IHG
A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

8. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very good, (1,592 reviews)
"Was a quick and comfortable stay."
United States
Tammy
The price is €76
includes taxes & fees
8 Nov - 9 Nov
AmericInn by Wyndham Rochester Near Mayo Clinic
A hotel lobby with a reception desk, seating area, and a bar.

9. Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area
2.0 star property
Rochester
7.8 out of 10, Good, (1,001 reviews)
"The staff was very friendly and helpful, I will definitely stay there again. The room was very clean."
United States
Rick
The price is €52
includes taxes & fees
22 Nov - 23 Nov
Super 8 by Wyndham Rochester Mayo Clinic Area
A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

10. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.6 out of 10, Good, (1,057 reviews)
"The staff were very friendly and helpful"
United States
saida
The price is €74
includes taxes & fees
22 Nov - 23 Nov
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
A spacious outdoor dining area with multiple tables and chairs, large windows, and a wooden ceiling structure.

11. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,002 reviews)
"Great location with easy access to Mayo Clinic and great food! The double queen room was clean and the beds were very comfortable. Will stay again!"
United States
Naomi
The price is €106
includes taxes & fees
14 Nov - 15 Nov
Hotel Indigo Rochester – Mayo Clinic Area by IHG
A hotel room with two beds, a desk, a chair, and a lamp.

12. Country Trails Inn & Suites

Country Trails Inn & Suites
2.0 star property
Preston
9.4 out of 10, Exceptional, (162 reviews)
"Very nice place to stay."
United States
Jeannie
The price is €125
includes taxes & fees
8 Nov - 9 Nov
Country Trails Inn & Suites
Interior detail

13. Birch Hill Suite Rochester – Med City

Birch Hill Suite Rochester – Med City
2.5 star property
Rochester
7.4 out of 10, Good, (98 reviews)
"Friendly, clean, nice kitchenette"
United States
Bonnie
The price is €60
includes taxes & fees
4 Nov - 5 Nov
Birch Hill Suite Rochester – Med City
A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

14. Days Inn by Wyndham Winona

Days Inn by Wyndham Winona
2.0 star property
Winona
7.6 out of 10, Good, (1,000 reviews)
"clean rooms and nice breakfast"
United States
William
The price is €69
includes taxes & fees
3 Dec - 4 Dec
Days Inn by Wyndham Winona
A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

15. Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
8.8 out of 10, Excellent, (668 reviews)
"The room was very clean and the beds were comfortable. Breakfast was good with lots of options."
United States
Tammy
The price is €85
includes taxes & fees
28 Nov - 29 Nov
Comfort Inn & Suites West - Medical Center
A multi-story building with a balcony, surrounded by various potted plants and flowers.

16. Green Gables Inn

Green Gables Inn
2.0 star property
Lanesboro
9.6 out of 10, Exceptional, (173 reviews)
"Best place to stay in Lanesboro area."
United States
Gary
The price is €124
includes taxes & fees
6 Nov - 7 Nov
Green Gables Inn
A hotel room with two beds, a desk, a chair, a TV, a wardrobe, and a window with curtains.

17. MainStay Suites Rochester South Mayo Clinic

MainStay Suites Rochester South Mayo Clinic
2.5 star property
Rochester
7.4 out of 10, Good, (147 reviews)
"Nice place"
United States
Stephen
The price is €65
includes taxes & fees
3 Dec - 4 Dec
MainStay Suites Rochester South Mayo Clinic
A modern living room with a fireplace, comfortable seating, and large windows.

18. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
3.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (560 reviews)
"Love love this hotel! Perfect for patients at Mayo and family"
United States
Amanda
The price is €110
includes taxes & fees
25 Nov - 26 Nov
Staybridge Suites Rochester - Mayo Clinic Area by IHG
A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

19. Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,003 reviews)
"Great stay"
United States
Susan
The price is €101
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn Rochester-South
A spacious lobby with a reception desk, sofas, and a coffee table.

20. Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center
2.5 star property
Rochester
9.0 out of 10, Wonderful, (722 reviews)
"Great location with courteous staff and clean rooms."
United States
Jacqueline
The price is €81
includes taxes & fees
29 Nov - 30 Nov
Sleep Inn & Suites West-Near Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

See all hotels in St. Charles
An aerial view of a town with industrial buildings, roads, and green areas.

Top St. Charles Hotel Reviews

Kahler Grand Hotel

Kahler Grand Hotel

10/10 Excellent
"When going to the Mayo Clinic this is the best place to stay. It's close, parking is easy. Will be back in 4 months again to stay the Kahler."
Jo 2-night trip
Posted 5 hours ago
Kahler Grand Hotel

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN
The price is €61 per night from 3 Dec to 4 Dec
€61
3 Dec - 4 Dec
includes taxes & fees
7.6/10 Good! (1,002 reviews)

Frequently asked questions

Where is the best place to stay in St. Charles?
AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.
What are some of the best holiday rentals that St. Charles has to offer?
Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This holiday home rental outside of St. Charles offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in St. Charles.
If I need to cancel my hotel reservation in St. Charles, will I receive a refund?
Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.
What's it like to stay in St. Charles?
Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.
What is there to see in St. Charles?
A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.
What's the weather like in St. Charles?
The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

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