Otay Mesa
San Diego
Popular places to visit
San Diego Zoo
Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's acclaimed art galleries and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
SeaWorld
Beautiful sea creatures, exhilarating rides and fun and educational displays – this marine park is a treat for all the family.
Balboa Park
This huge city-centre park is home to a range of fantastic cultural institutions, and it’s also a lovely place for a walk.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
From Tijuana: Valle de Guadalupe Private Winery Tour
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
From Tijuana: Valle de Guadalupe Shared Winery Tour
Top hotels in Otay Mesa
Hotel del Coronado, Curio Collection by Hilton
Balcony room in the Victorian was lovely, a good size and plenty of storage for clothes etc. Loved the shops on the lower T level and the restaurants were amazing. Valet parking is expensive but so slick and made traveling out so easy. Will definitely stay at The Del when I go back to San Diego
Reviewed on 17 Nov 2025
Legacy Resort Hotel & Spa
Room was clean and spacious
Reviewed on 14 Nov 2025
Hilton San Diego Mission Valley
Room was spotless, nice room. Good area
Reviewed on 15 Nov 2025
Bay Club Hotel & Marina
Dining was lovely overlooking the marina. Staff was friendly, courteous. Would stay here again
Reviewed on 15 Nov 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
Hotel, inside and outside clean. Rooms, lobby and gym and hallways clean, spacious, sufficient elevators. Modern, new and spacious. Gym was real nice with good equipment. The staff was real professional and friendly. Breakfast was delicious. The streets/areas/traffic near me of the hotel were ...
Reviewed on 15 Nov 2025
Hard Rock Hotel San Diego
Staff was great Our suite was extremely nice the sound system was great. Gaslamp area was great lots of great food.
Reviewed on 17 Nov 2025
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
