What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Otay Mesa hotels, San Diego, United States of America: San Diego Hotel Guide

A city skyline with high-rise buildings and a bridge over a body of water.

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Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Otay Mesa

Helen

includes taxes & fees

23 Nov - 24 Nov

A hotel room with a kitchenette, dining area, and a ceiling fan.

2. Quality Suites San Diego Otay Mesa

Otay Mesa

Anonymous traveller

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with a fireplace, wooden furniture, and a chandelier.

3. Best Western Americana Inn

8 km from Otay Mesa

Rene

includes taxes & fees

1 Nov - 2 Nov

A neatly arranged hotel room with a large bed, a desk, a chair, and a bedside table.

4. Valli Hi Motel

7.9 km from Otay Mesa

Christian

includes taxes & fees

2 Nov - 3 Nov

A hotel room with two beds, a television, a desk, and a dresser.

5. La Quinta Inn by Wyndham San Diego Chula Vista

12.9 km from Otay Mesa

Nuwan

includes taxes & fees

8 Nov - 9 Nov

A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

6. Comfort Inn Chula Vista San Diego South

13 km from Otay Mesa

Xochitl

includes taxes & fees

22 Nov - 23 Nov

An outdoor patio area with seating and a bar.

7. Ayres Hotel San Diego South - Chula Vista

6.5 km from Otay Mesa

Rosemary

includes taxes & fees

11 Nov - 12 Nov

A hotel room with two beds, a desk, and a chair.

8. Howard Johnson by Wyndham National City/San Diego South

18.3 km from Otay Mesa

Claudia

includes taxes & fees

27 Oct - 28 Oct

A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

9. The Rambler Hotel

14.8 km from Otay Mesa

Neal

includes taxes & fees

9 Nov - 10 Nov

A hotel with a swimming pool, multiple floors, and a view of the surrounding area.

10. SpringHill Suites by Marriott Chula Vista Eastlake

10.5 km from Otay Mesa

Joey

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

11. Hotel Palmeras Chula Vista

14.4 km from Otay Mesa

AHMAD

includes taxes & fees

29 Oct - 30 Oct

A modern living room with a stone fireplace, sofas, a coffee table, and a view of the upper floor.

12. Best Western Plus Marina Gateway Hotel

16.9 km from Otay Mesa

Nicholas Ray

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a large bed, a desk with a chair, a nightstand, a mirror, and a blue-striped carpet.

13. Best Western Chula Vista/Otay Valley Hotel

7.1 km from Otay Mesa

Mario

includes taxes & fees

8 Nov - 9 Nov

A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

14. Hercor Hotel - Urban Boutique

13.6 km from Otay Mesa

fannie

includes taxes & fees

18 Nov - 19 Nov

A hotel lobby with a waterfall feature, outdoor seating area, and multiple floors with balconies.

15. Crowne Plaza San Diego - Mission Valley by IHG

29.8 km from Otay Mesa

Thao

includes taxes & fees

29 Oct - 30 Oct

A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

16. Holiday Inn Express San Diego South - Chula Vista by IHG

14.5 km from Otay Mesa

Daniel

includes taxes & fees

5 Nov - 6 Nov

A balcony with a wicker chair, a view of high-rise buildings, and a small garden area.

17. Ash&9th

24.7 km from Otay Mesa

andrew h

includes taxes & fees

17 Nov - 18 Nov

A balcony with wicker furniture overlooking a marina and a coastal cityscape.

18. Sheraton San Diego Resort

28.1 km from Otay Mesa

James

includes taxes & fees

22 Nov - 23 Nov

A compact living space with a dining table set for two, a sofa, a wall-mounted TV, and a large window with curtains.

19. The Neon Elm Hotel

25.4 km from Otay Mesa

Cory

includes taxes & fees

27 Oct - 28 Oct

A hotel reception area with marble columns, a reception desk, and a large illuminated wall with bokeh lights.

20. Sycuan Casino Resort

28.5 km from Otay Mesa

Sarah

includes taxes & fees

16 Nov - 17 Nov

View all properties

Compare popular hotels in Otay Mesa

Property	Property class	Guest rating
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG	2.5 star property	8.4 Very good 1,939 reviews	View
Quality Suites San Diego Otay Mesa	2.5 star property	7.2 Good 1,001 reviews	View
Ayres Hotel San Diego South - Chula Vista	3.0 star property	9.8 Exceptional 1,037 reviews	View
Best Western Americana Inn	2.5 star property	8.8 Excellent 1,419 reviews	View
SpringHill Suites by Marriott Chula Vista Eastlake	3.5 star property	9.6 Exceptional 806 reviews	View

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

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Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

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A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

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An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

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Top Otay Mesa Hotel Reviews

Hard Rock Hotel San Diego

10/10 Excellent

"Location is perfect, the staff goes out of their way to make you feel welcome and the room is amazing, spacious, sparkling clean and comfortable."

The Sofia Hotel

10/10 Excellent

"Second time staying at The Sofia for work. Previously when travelling for work to San Diego I used to stay at other renowned, big brand, hotels nearby, sometimes at triple or quadruple the cost. The Sofia is in my opinion the best kept secret in the city. It is in many aspects as good as those big brand names, and in many more it is WAY better. If you are looking for a high quality, quiet, and comfortable stay without that feeling of "what am I paying so much for", then look no further."

San Diego Hotel Guide. Hotels in Otay Mesa, San Diego, United States of America

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Our top choices for Otay Mesa hotels

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2. Quality Suites San Diego Otay Mesa

3. Best Western Americana Inn

4. Valli Hi Motel

5. La Quinta Inn by Wyndham San Diego Chula Vista

6. Comfort Inn Chula Vista San Diego South

7. Ayres Hotel San Diego South - Chula Vista

8. Howard Johnson by Wyndham National City/San Diego South

9. The Rambler Hotel

10. SpringHill Suites by Marriott Chula Vista Eastlake

11. Hotel Palmeras Chula Vista

12. Best Western Plus Marina Gateway Hotel

13. Best Western Chula Vista/Otay Valley Hotel

14. Hercor Hotel - Urban Boutique

15. Crowne Plaza San Diego - Mission Valley by IHG

16. Holiday Inn Express San Diego South - Chula Vista by IHG

17. Ash&9th

18. Sheraton San Diego Resort

19. The Neon Elm Hotel

20. Sycuan Casino Resort

Compare popular hotels in Otay Mesa

Where to stay in Otay Mesa

Downtown San Diego

Pacific Beach

Gaslamp Quarter

Mission Beach

Mission Bay

Top Otay Mesa Hotel Reviews

Hard Rock Hotel San Diego

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