San Diego Hotel Guide. Hotels in Otay Mesa, San Diego, United States of America
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Our top choices for Otay Mesa hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very good, (1,585 reviews)
"Great place to stay. Really clean and helpful staff "
Zulma
The price is €131
includes taxes & fees
18 Jan - 19 Jan
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.0 out of 10, Good, (1,002 reviews)
"Clean, convenient location "
Mary
The price is €104
includes taxes & fees
18 Jan - 19 Jan
Sycuan Casino Resort
Sycuan Casino Resort28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,669 reviews)
"Very clean resort. "
Petrina
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld31.3 km from Otay Mesa
7.4 out of 10, Good, (4,131 reviews)
"Get location to the airport, safe, great staff, & overall wonderful stay"
Tyler
The price is €84
includes taxes & fees
19 Jan - 20 Jan
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and MarinaMission Bay, 33.9 km from Otay Mesa
8.4 out of 10, Very good, (1,600 reviews)
"Beautiful grounds with lots of activities for all ages."
Brandon
The price is €196
includes taxes & fees
30 Jan - 31 Jan
The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier Collection25.4 km from Otay Mesa
9.0 out of 10, Wonderful, (889 reviews)
"beautiful hotel , amazing staff, & yummy breakfast!! "
Makayla
The price is €110
includes taxes & fees
22 Jan - 23 Jan
Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHG29.8 km from Otay Mesa
7.8 out of 10, Good, (1,003 reviews)
"Great stay"
Viviann
The price is €92
includes taxes & fees
25 Jan - 26 Jan
Best Western Yacht Harbor Hotel
Best Western Yacht Harbor Hotel29.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,670 reviews)
"Spotless room, nice staff, great breakfast"
DAVID
The price is €83
includes taxes & fees
12 Jan - 13 Jan
San Diego Mission Bay Resort
San Diego Mission Bay ResortMission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,333 reviews)
"Loved the bay front room with the large grass area right out the door!"
Todd and Danielle
The price is €196
includes taxes & fees
2 Feb - 3 Feb
Comfort Inn San Diego Old Town
Comfort Inn San Diego Old TownOld Town San Diego, 29.6 km from Otay Mesa
8.2 out of 10, Very good, (1,925 reviews)
"Great stay "
Vanessa
The price is €92
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn San Diego-Downtown
Hampton Inn San Diego-Downtown25.8 km from Otay Mesa
8.2 out of 10, Very good, (2,332 reviews)
"Nice and convenient place to stay!"
Esperanza
The price is €122
includes taxes & fees
25 Jan - 26 Jan
Paradise Point Resort & Spa
Paradise Point Resort & SpaMission Bay, 34.5 km from Otay Mesa
8.6 out of 10, Excellent, (2,368 reviews)
"Great facility and amenities. We look forward to taking our family back again. "
Andy
The price is €147
includes taxes & fees
19 Jan - 20 Jan
Kings Inn San Diego
Kings Inn San Diego29.1 km from Otay Mesa
8.8 out of 10, Excellent, (3,598 reviews)
"Good location, friendly staff"
Natalia
Days Inn by Wyndham San Diego Hotel Circle
Days Inn by Wyndham San Diego Hotel Circle28.8 km from Otay Mesa
8.0 out of 10, Very good, (2,439 reviews)
"Good budget hotel."
MD
The price is €79
includes taxes & fees
15 Jan - 16 Jan
Wyndham San Diego Bayside
Wyndham San Diego Bayside25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,013 reviews)
"Perfect location for leaving on a cruise!"
Hope
The price is €165
includes taxes & fees
13 Jan - 14 Jan
The Atwood Hotel San Diego - SeaWorld/Zoo
The Atwood Hotel San Diego - SeaWorld/Zoo29.1 km from Otay Mesa
8.0 out of 10, Very good, (1,854 reviews)
"Great place "
Michelle
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San DiegoMarina District, 24.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,885 reviews)
"Excellent stay...wonderful staff"
Michelle
The price is €245
includes taxes & fees
22 Jan - 23 Jan
Best Western Americana Inn
Best Western Americana Inn8 km from Otay Mesa
8.8 out of 10, Excellent, (1,201 reviews)
"Great staff!"
Gerald
The price is €107
includes taxes & fees
18 Jan - 19 Jan
Hampton Inn & Suites by Hilton San Diego SeaWorld
Hampton Inn & Suites by Hilton San Diego SeaWorld30.8 km from Otay Mesa
9.2 out of 10, Wonderful, (512 reviews)
"Excellent hotel!"
Jorge
The price is €108
includes taxes & fees
19 Jan - 20 Jan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Ocean Beach
Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Ocean Beach Farmers Market.
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