San Diego Hotel Guide. Hotels in Otay Mesa, San Diego, United States of America

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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,695 reviews)
"Great breakfast!"
United States
Susan
The price is €106
includes taxes & fees
10 May - 11 May
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,009 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is €96
includes taxes & fees
10 May - 11 May
Quality Suites San Diego Otay Mesa

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,016 reviews)
"Great location, near shops, restaurants and beaches. "
United States
Miguelina
The price is €74
includes taxes & fees
14 Apr - 15 Apr
Valli Hi Motel

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,849 reviews)
"Awesome place "
United States
Jonathan
The price is €127
includes taxes & fees
15 Apr - 16 Apr
Sycuan Casino Resort

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very good, (1,593 reviews)
"Good location"
United States
Joshua
The price is €73
includes taxes & fees
14 Apr - 15 Apr
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,258 reviews)
"Great place and service. Will definitely stay there again. "
United States
Maria
The price is €119
includes taxes & fees
19 Apr - 20 Apr
Best Western Americana Inn

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,245 reviews)
"great place"
Canada
souheil
The price is €96
includes taxes & fees
14 Apr - 15 Apr
Wyndham Garden San Diego Near SeaWorld

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
29.8 km from Otay Mesa
8.0 out of 10, Very good, (1,056 reviews)
"Great place to stay"
United States
Kimberly
The price is €116
includes taxes & fees
27 Apr - 28 Apr
Crowne Plaza San Diego - Mission Valley by IHG

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,583 reviews)
"Everything about that stay was perfect"
United States
Victoria
The price is €244
includes taxes & fees
16 Apr - 17 Apr
Lafayette Hotel & Club

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,638 reviews)
"Clean room ,friendly staff "
United States
Danny
The price is €69
includes taxes & fees
14 Apr - 15 Apr
Motel 6 El Cajon, CA - San Diego

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,233 reviews)
"Amazing def will stay again "
United States
Tanya
The price is €116
includes taxes & fees
16 Apr - 17 Apr
Ocean Villa Inn

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,470 reviews)
"Nice hotel with great location "
United States
DIANA
The price is €202
includes taxes & fees
8 May - 9 May
Sheraton San Diego Resort

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (624 reviews)
"By far, one of the best hotels we have stayed at! Very clean, friendly and knowledgeable front desk staff, amenities galore and right across the street from family friendly entertainment venues like play city and ninja factory. The pool was amazing - we had all a great time! "
United States
Daniel
The price is €177
includes taxes & fees
10 May - 11 May
SpringHill Suites by Marriott Chula Vista Eastlake

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.6 out of 10, Good, (1,008 reviews)
"My room was perfect in every way. The complimentary breakfast was excellent, plenty of variety and quantity with nice seating. Day’s Inn has a great location for traveling on foot, bus or trolley to many locations. I will stay here again on my next trip. "
United States
Marla
The price is €87
includes taxes & fees
15 Apr - 16 Apr
Days Inn by Wyndham San Diego-East/El Cajon

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,404 reviews)
"The restaurant on site was delicious "
United States
Blanca
The price is €240
includes taxes & fees
10 May - 11 May
San Diego Mission Bay Resort

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.2 out of 10, Good, (2,208 reviews)
"Its always a great stay, thanks "
United States
Dulce
The price is €67
includes taxes & fees
14 Apr - 15 Apr
Hotel Palmeras Chula Vista

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,097 reviews)
"Room was clean, amenities were stocked, breakfast was yummy. I would definitely stay there again."
United States
Fabiola
The price is €126
includes taxes & fees
10 May - 11 May
Holiday Inn Express San Diego South - Chula Vista by IHG

Ocean Beach Hotel

Ocean Beach Hotel
3.0 star property
Ocean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,297 reviews)
"Cute place, easy location & staff was so friendly. "
United States
Ericka A
The price is €173
includes taxes & fees
20 Apr - 21 Apr
Ocean Beach Hotel

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
31.8 km from Otay Mesa
7.4 out of 10, Good, (1,373 reviews)
"Great and easy way to check in and out!"
United States
Pedro
The price is €60
includes taxes & fees
14 Apr - 15 Apr
Heritage Inn San Diego

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very good, (1,002 reviews)
"Very comfortable room and close to cool restaurants"
United States
Samantha
The price is €95
includes taxes & fees
14 Apr - 15 Apr
Berkshire Motor Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Sunset Cliffs Natural Park.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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