What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Otay Mesa hotels, San Diego, United States of America: San Diego Hotel Guide

A city skyline with high-rise buildings and a bridge over a body of water.

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Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Otay Mesa

Kuljit

includes taxes & fees

11 Oct - 12 Oct

A breakfast station with bread, bagels, waffles, and a coffee machine.

2. Quality Suites San Diego Otay Mesa

Otay Mesa

Mia

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a fireplace, wooden furniture, and a chandelier.

3. Best Western Americana Inn

8 km from Otay Mesa

Luis

includes taxes & fees

20 Sept - 21 Sept

An outdoor patio area with seating and a bar.

4. Ayres Hotel San Diego South - Chula Vista

6.5 km from Otay Mesa

Shan Shan

includes taxes & fees

11 Oct - 12 Oct

A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

5. Comfort Inn Chula Vista San Diego South

13 km from Otay Mesa

Katsuya

includes taxes & fees

11 Oct - 12 Oct

A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

6. La Quinta Inn by Wyndham San Diego Chula Vista

12.9 km from Otay Mesa

Sharon

includes taxes & fees

11 Oct - 12 Oct

7. SpringHill Suites by Marriott Chula Vista Eastlake

10.5 km from Otay Mesa

Alfonso

includes taxes & fees

11 Oct - 12 Oct

A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

8. The Rambler Hotel

14.8 km from Otay Mesa

Tracy

includes taxes & fees

5 Oct - 6 Oct

A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

9. Hotel Palmeras Chula Vista

14.4 km from Otay Mesa

Idanesha

includes taxes & fees

13 Sept - 14 Sept

A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

10. Hercor Hotel - Urban Boutique

13.6 km from Otay Mesa

Jhon

includes taxes & fees

27 Sept - 28 Sept

A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.

11. Best Western Plus Marina Gateway Hotel

16.9 km from Otay Mesa

Alexander

includes taxes & fees

13 Sept - 14 Sept

A hotel room with two beds, a desk, and a chair.

12. Howard Johnson by Wyndham National City/San Diego South

18.3 km from Otay Mesa

Erika

includes taxes & fees

1 Oct - 2 Oct

A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

13. Holiday Inn Express San Diego South - Chula Vista by IHG

14.5 km from Otay Mesa

Cathie

includes taxes & fees

20 Sept - 21 Sept

A swimming pool with palm trees and a mountain in the background.

14. Sycuan Casino Resort

28.5 km from Otay Mesa

Tom

includes taxes & fees

5 Oct - 6 Oct

A spacious living room with a large arched window, a red sofa, a coffee table, and a chandelier.

15. Lamplighter Inn & Suites at SDSU

24.4 km from Otay Mesa

Bernadette

includes taxes & fees

7 Oct - 8 Oct

A multi-story hotel with a prominent entrance, a stone facade, and a clear sky.

16. WoodSpring Suites Santee - San Diego Northeast

30.9 km from Otay Mesa

Adan

includes taxes & fees

14 Sept - 15 Sept

A motel sign with a directional arrow and a number '6' indicating the entrance.

17. Motel 6 El Cajon, CA - San Diego

27 km from Otay Mesa

Melissa

includes taxes & fees

1 Oct - 2 Oct

A bar area with a glass ceiling, a central bar counter, and multiple stools.

18. Lafayette Hotel & Club

26.8 km from Otay Mesa

Angela

includes taxes & fees

14 Sept - 15 Sept

A compact living space with a dining table set for two, a sofa, a wall-mounted TV, and a large window with curtains.

19. The Neon Elm Hotel

25.4 km from Otay Mesa

Ahmad

includes taxes & fees

30 Sept - 1 Oct

A multi-story hotel with a lobby, outdoor seating, and a well-lit entrance.

20. The Alcala Hotel Mission Valley/Seaworld

30.2 km from Otay Mesa

Tranquilino

includes taxes & fees

13 Sept - 14 Sept

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Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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A pier at sunset with people sitting and standing, waves crashing below.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

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Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

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A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

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An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

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Top Otay Mesa Hotel Reviews

Wyndham San Diego Bayside

10/10 Excellent

"Great super location"

Paradise Point Resort & Spa

8/10 Good

"Check in is at 4pm and the only bar on site closes at 5pm. The following day we found out that the Island Store sells alcohol. Food is provided by 2 restaurants near by but we found out that using door dash was better. The restaurant we really wanted to eat at was closed for Labor Day. Staff was accommodating and overall we had a great time."

San Diego Hotel Guide. Hotels in Otay Mesa, San Diego, United States of America

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Our top choices for Otay Mesa hotels

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2. Quality Suites San Diego Otay Mesa

3. Best Western Americana Inn

4. Ayres Hotel San Diego South - Chula Vista

5. Comfort Inn Chula Vista San Diego South

6. La Quinta Inn by Wyndham San Diego Chula Vista

7. SpringHill Suites by Marriott Chula Vista Eastlake

8. The Rambler Hotel

9. Hotel Palmeras Chula Vista

10. Hercor Hotel - Urban Boutique

11. Best Western Plus Marina Gateway Hotel

12. Howard Johnson by Wyndham National City/San Diego South

13. Holiday Inn Express San Diego South - Chula Vista by IHG

14. Sycuan Casino Resort

15. Lamplighter Inn & Suites at SDSU

16. WoodSpring Suites Santee - San Diego Northeast

17. Motel 6 El Cajon, CA - San Diego

18. Lafayette Hotel & Club

19. The Neon Elm Hotel

20. The Alcala Hotel Mission Valley/Seaworld

Where to stay in Otay Mesa

Downtown San Diego

Pacific Beach

Gaslamp Quarter

Mission Beach

Mission Bay

Top Otay Mesa Hotel Reviews

Wyndham San Diego Bayside

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