Otay Mesa
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
From Tijuana: Valle de Guadalupe Private Winery Tour
Mexican Street Food: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour
Crossing Borders: Tijuana Day Trip from San Diego
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Top hotels in Otay Mesa
Handlery Hotel
Best Western Seven Seas
"The reception staff were unsmiling and cold, like machines. They did help me with my request to change my room, and made no mistakes. They just seemed unfriendly and disinterested. The first room I was assigned had no mattress pad on the bed, and no functioning ports of the 3 USB ports in the room. ..."
Reviewed on 13 Sept 2026
Paradise Point Resort & Spa
Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego
Bay Club Hotel & Marina
Where to stay in Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
