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Panama City Hotel Guide. Hotels in San Francisco, Panama City, Panama

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15 Dec - 16 Dec
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19 Dec - 21 Dec
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Our top choices for San Francisco hotels

Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
San Francisco
8.4 out of 10, Very good, (1274)
"Clean rooms, staff was amazing!!"
United States
Christopher
The price is €130
includes taxes & fees
19 Dec - 20 Dec
Megapolis Hotel Panamá
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2137)
"Great location, friendly staff, excellent views and the best breakfast around."
Canada
Gregory
The price is €101
includes taxes & fees
19 Dec - 20 Dec
Plaza Paitilla Inn Hotel
Exterior
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1004)
"Staff was very helpful. Great location."
United States
John
The price is €87
includes taxes & fees
10 Jan - 11 Jan 2026
Courtyard by Marriott Panama Multiplaza Mall
Outdoor pool, pool umbrellas, pool loungers
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1121)
"Great hotel, clean, great costumer service "
United States
Eduardo Francisco
The price is €102
includes taxes & fees
21 Dec - 22 Dec
Ramada Plaza by Wyndham Panama Punta Pacifica
View from property
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1014)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is €164
includes taxes & fees
10 Jan - 11 Jan 2026
Las Americas Golden Tower Panama
Exterior
Decapolis Hotel Panama City

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
San Francisco
8.6 out of 10, Excellent, (1452)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is €106
includes taxes & fees
14 Jan - 15 Jan 2026
Decapolis Hotel Panama City
Outdoor pool
Boutique Apartments Atlapa

Boutique Apartments Atlapa

Boutique Apartments Atlapa
3.0 star property
San Francisco
7.8 out of 10, Good, (27)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa
Terrace/patio
Casa Orquídea

Casa Orquídea

Casa Orquídea
2.0 star property
San Francisco
8.0 out of 10, Very good, (5)
"Yes"
United States
george
The price is €55
includes taxes & fees
17 Dec - 18 Dec
Casa Orquídea
Terrace/patio
Sheraton Grand Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (993)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is €126
includes taxes & fees
9 Jan - 10 Jan 2026
Sheraton Grand Panama
4 outdoor pools, free pool cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1007)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is €235
includes taxes & fees
4 Jan - 5 Jan 2026
JW Marriott Panama
Exterior
Aloft Panama

Aloft Panama

Aloft Panama
3.5 star property
San Francisco
8.8 out of 10, Excellent, (892)
"The staff was very friendly, rooms were clean and modern."
United States
Greg
The price is €110
includes taxes & fees
22 Dec - 23 Dec
Aloft Panama
Exterior
Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member
3.0 star property
San Francisco
The price is €211
includes taxes & fees
29 Dec - 30 Dec
Dovle Residences by HMS-Preferred Member
Living area
Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments
3.0 star property
San Francisco
The price is €174
includes taxes & fees
29 Dec - 30 Dec
Living 73 Panamá by Boutique Apartments
Outdoor pool, open 6:00 AM to 11:00 PM, pool umbrellas, pool loungers
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (538)
"It's location is close to everything. "
United States
Sharon
The price is €143
includes taxes & fees
2 Jan - 3 Jan 2026
Residence Inn by Marriott Panama City
Outdoor pool
Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments
4.0 star property
San Francisco
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is €280
includes taxes & fees
17 Dec - 18 Dec
Wanders Panama by Boutique Apartments
Lobby sitting area
San Francisco by Wynwood House

San Francisco by Wynwood House

San Francisco by Wynwood House
3.0 star property
San Francisco
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is €148
includes taxes & fees
17 Dec - 18 Dec
San Francisco by Wynwood House
Apartment
w Bright 1BR w Private Balcony in San Francisco

w Bright 1BR w Private Balcony in San Francisco

w Bright 1BR w Private Balcony in San Francisco
2.0 star property
San Francisco
w Bright 1BR w Private Balcony in San Francisco
Outdoor pool
Wanders & Yoo

Wanders & Yoo

Wanders & Yoo
4.0 star property
San Francisco
8.2 out of 10, Very good, (10)
"Cool and modern condos, great location and views."
United States
Jorge
The price is €273
includes taxes & fees
4 Jan - 5 Jan 2026
Wanders & Yoo
Apartment
Brand New 2BR apt w Gym and Pool

Brand New 2BR apt w Gym and Pool

Brand New 2BR apt w Gym and Pool
2.0 star property
San Francisco
Brand New 2BR apt w Gym and Pool
Apartment
Urban 2BR Apt in Central Area

Urban 2BR Apt in Central Area

Urban 2BR Apt in Central Area
2.0 star property
San Francisco
Urban 2BR Apt in Central Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in San Francisco

Find the best San Francisco areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top San Francisco Hotel Reviews

Marriott Panama Hotel

Marriott Panama Hotel

10/10 Excellent
"Great hotel and staff!"
Catherine 4-night trip
Posted 4 hours ago
Marriott Panama Hotel

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Frequently asked questions

What is San Francisco like?
San Francisco is a welcoming neighbourhood that travellers like for its restaurants. Make sure that you visit Multiplaza Pacific Mall and Calle 50 as part of your San Francisco travel plans.
Where is the best hotel for a stay in San Francisco?
Based on Expedia customer reviews, Ramada Plaza by Wyndham Panama Punta Pacifica is the highest ranked property in San Francisco. This hotel is a short 4-minute walk from Multiplaza Pacific Mall, and it offers free breakfast and a restaurant. Other top choices in the neighbourhood include Residence Inn by Marriott Panama City and JW Marriott Panama.
How many hotels can I expect to find in San Francisco?
If you're searching for places to stay in Panama City, Expedia has something to meet your needs with 264 San Francisco hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! Most hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in San Francisco.
What is there to do in this Panama City neighbourhood?
While you're in San Francisco, a shopping trip to Multiplaza Pacific Mall, Avenida Balboa or Pacific Center might be the perfect way to find that souvenir you've been looking for. Calle 50 and Panama Canal Murals are some other stops worth a visit in the neighbourhood. A few places to visit in the area around San Francisco include Colonial Religious Art Museum, Bingo 90 and Soho City Center. When you're sightseeing in Panama City, National Shrine of the Heart of Mary and Panama Viejo Museum are also worth a stop.