San Francisco Holidays

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  • Better together

    Save up to €900 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Plan, book, and manage your trip all in one place
Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was €1,222, price is now €1,053 per person
€1,053
per person
22 Jul - 25 Jul
found 1 day ago
Return direct flight included
George Town (GCM) to Panama City (PTY)
8.4/10 Very Good! (1,825 reviews)
They waited till my very late arrival...and provided a fabulous service

Reviewed on 12 Jun 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was €1,855, price is now €1,264 per person
€1,264
per person
22 Jul - 25 Jul
found 1 day ago
Return direct flight included
George Town (GCM) to Panama City (PTY)
8.4/10 Very Good! (1,553 reviews)
This was absolutely fabulous! The buffet in the mornings were the best part to start your day with fresh omelets and freshly squeezed juices with all of the bells and whistles of a buffet. I would definitely come back to stay.

Reviewed on 10 Jun 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was €1,537, price is now €1,219 per person
€1,219
per person
22 Jul - 25 Jul
found 1 day ago
Return direct flight included
George Town (GCM) to Panama City (PTY)
9.2/10 Wonderful! (1,011 reviews)
Central Panama hotel was fantastic. Right across from the Herrera Central Park where all kinds of events happen. The hotel is very clean and elegant. Live soft music plays in the lobby every day, wheater a guitar, piano or trumpet players suit the guests ears while they dine or relax. Breakfast buffet is delicious. Staff are very kind, they go out of their way to make sure you have a great stay 😀

Reviewed on 13 Jun 2026

Las Clementinas

Las Clementinas

3.5 out of 5
Casco Viejo
Price was €1,261, price is now €1,111 per person
€1,111
per person
22 Jul - 25 Jul
found 1 day ago
Return direct flight included
George Town (GCM) to Panama City (PTY)
9.4/10 Exceptional! (192 reviews)
Amazing property. Beautiful rooms. We reserved two rooms because we have a large family. Both rooms were amazing. The front desk clerk was one of the kindest and sweetest people I’ve met in my life. Would definitely return.

Reviewed on 14 Jun 2026

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Casco Viejo
Price was €1,519, price is now €1,359 per person
€1,359
per person
22 Jul - 25 Jul
found 1 day ago
Return direct flight included
George Town (GCM) to Panama City (PTY)
9.8/10 Exceptional! (660 reviews)
Hotel is in what they call old city (area looks colonial). There are many stores in the area for shopping. The hotel itself is nice. The staff was friendly. The pool was beautiful and I had a great time using the on site spa. The rooftop restaurant had good food and live entertainmen. The hotel was well kept.

Reviewed on 9 Jun 2026

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in San Francisco

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
The price is €142 per night from 4 Jul to 5 Jul
€142
4 Jul - 5 Jul
includes taxes & fees
8.6/10 Excellent! (1,002 reviews)
"Everything is great"

Reviewed on 9 Jun 2026

Sheraton Grand Panama
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
The price is €135 per night from 20 Jun to 21 Jun
€135
20 Jun - 21 Jun
includes taxes & fees
9/10 Wonderful! (1,044 reviews)
"It was a nice, clean, and quiet hotel for a quick layover. I enjoyed the amenities, the room service was a plus. it also had a great a great city view and a restaurant in the hotel. I enjoyed it, I would recommend."

Reviewed on 14 Jun 2026

Las Americas Golden Tower Panama
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
Fully refundableReserve now, pay when you stay
The price is €108 per night from 4 Jul to 5 Jul
€108
4 Jul - 5 Jul
includes taxes & fees
9/10 Wonderful! (1,007 reviews)
"The room was nice and clean. Bed was properly made up, towels were changed everyday. The mall was convenient as it was right next door. I will definitely recommend this hotel to anyone i know that will be travelling to Panama."

Reviewed on 13 Jun 2026

Courtyard by Marriott Panama Multiplaza Mall
See all 1,771 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Francisco holiday package cost?
Much less than you might think — from a low €1,053, in fact! By bundling hotels, flights and car rentals into a custom-built holiday package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco holiday package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes travelling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Centre. Ph Boutique Quartier Atlapa or New Cosy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travellers.
How far in advance should I book my San Francisco holiday?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco holiday looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia holiday package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco holiday package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco holiday package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Stay near popular San Francisco attractions

Multiplaza Pacific Mall

4.5/5 (4,497 reviews)
During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
See properties
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.