Santa Cruz Holidays

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    Better together

    Save up to €185 when you book a flight and hotel together*
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    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Plan, book, and manage your trip all in one place

Top Flight + Hotel Deals in Santa Cruz

Price found within the past 48 hours. Click for updated prices.
Hotel & Suites PF

Hotel & Suites PF

3.5 out of 5
Reforma
Price was €497, price is now €340 per person
€340
per person
7 Nov - 10 Nov
found 1 day ago
Return flight included
Guatemala City (GUA) to Mexico City (MEX)
8.6/10 Excellent! (1,996 reviews)
I liked their friendliness. I felt at home.

Reviewed on 18 Aug 2025

Casa de la Luz Hotel Boutique

Casa de la Luz Hotel Boutique

4 out of 5
Historic Center
Save 100% on your flight
Price was €932, price is now €474 per person
€474
per person
7 Nov - 10 Nov
found 1 day ago
Return flight included
Guatemala City (GUA) to Mexico City (MEX)
9.6/10 Exceptional! (381 reviews)
Amazing hotel and staff was exceptional. From the front desk attendants and all the other staff, we want to say thank you so much for making our visit memorable. The location was in the middle of the historic district which made it easy to visit many sites. The restaurant in the hotel is also one of the best places we ate during our visit. We will definitely be staying here when we come back. Highly recommended for first time visitors and returning visitors.

Reviewed on 24 Aug 2025

Maria Condesa

Maria Condesa

4 out of 5
La Condesa
Price was €631, price is now €403 per person
€403
per person
7 Nov - 10 Nov
found 1 day ago
Return flight included
Guatemala City (GUA) to Mexico City (MEX)
8.8/10 Excellent! (759 reviews)
The staff were incredible and super nice

Reviewed on 28 Jul 2025

Ubicuo Hotel Boutique

Ubicuo Hotel Boutique

3 out of 5
Reforma
Price was €1,104, price is now €725 per person
€725
per person
31 Oct - 3 Nov
found 1 day ago
Return flight included
Guatemala City (GUA) to Mexico City (MEX)
No reviews
Galeria Plaza Reforma

Galeria Plaza Reforma

4 out of 5
Reforma
Save 100% on your flight
Price was €1,262, price is now €841 per person
€841
per person
31 Oct - 3 Nov
found 1 day ago
Return flight included
Guatemala City (GUA) to Mexico City (MEX)
9.4/10 Exceptional! (2,855 reviews)
It is convenient for shopping and dining. It is very noisy at night during the bars nearby. You may hear boom sounds until 2:00 am.

Reviewed on 23 Aug 2025

Top hotels in Santa Cruz

Hyatt Regency Mexico City

Hyatt Regency Mexico City

5 out of 5
Campos Eliseos No. 204 Polanco, Chapultepec, Mexico City
Fully refundableReserve now, pay when you stay
The price is €197 per night from 7 Sept to 8 Sept
€197
7 Sept - 8 Sept
includes taxes & fees
9.2/10 Wonderful! (1,180 reviews)
"Recommend it!"

Reviewed on 25 Aug 2025

Hyatt Regency Mexico City
InterContinental Presidente Mexico City by IHG

InterContinental Presidente Mexico City by IHG

4 out of 5
Campos Eliseos 218, Mexico City
The price is €266 per night from 19 Sept to 20 Sept
€266
19 Sept - 20 Sept
includes taxes & fees
9.2/10 Wonderful! (1,881 reviews)
"Excellent. Amazing views"

Reviewed on 21 Aug 2025

InterContinental Presidente Mexico City by IHG
Casa Olea

Casa Olea

2 out of 5
C. de Francisco Díaz Covarrubias, 76, Mexico City, CDMX
Fully refundableReserve now, pay when you stay
The price is €64 per night from 4 Sept to 5 Sept
€64
4 Sept - 5 Sept
includes taxes & fees
9.4/10 Exceptional! (442 reviews)
"I enjoyed the property however I wish they had AC because it can get stuffy and humid"

Reviewed on 22 Aug 2025

Casa Olea
See all 1,813 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Tula de Allende

National Museum of the Viceroyalty

Marvel at the dazzling exhibitions of well-preserved colonial art on display inside one of Mexico’s finest examples of Baroque architecture.

National Museum of the Viceroyalty

What to do in Santa Cruz

ATV Adventure

Private Jeep & ATV Tour to Jade Cavern in Cozumel: All-Inclusive

€112
per adult
Private Jeep & ATV Tour to Jade Cavern in Cozumel: All-Inclusive
Forest Bathing Nature Sensory Immersion Tour

Immerse in the Nature: Deep Connection through Forest Bathing

€64
per adult
Immerse in the Nature: Deep Connection through Forest Bathing
Polaris Razor Jungle Adventure & Beach Getaway

Cozumel Razor Expeditions: Jungle & Beach getaway

€111
per adult
Cozumel Razor Expeditions: Jungle & Beach getaway
See all activities in Santa Cruz

Frequently asked questions

How much does a Santa Cruz holiday package cost?
Offering excellent value package deals from €340 on Expedia, you'll be pleasantly surprised at how much a holiday to Santa Cruz costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to Santa Cruz?
You can usually find reduced prices and better availability in January, February and June. Explore our cheap Santa Cruz holiday packages and you could score some great off-season discounts.
How many days is enough for Santa Cruz?
The ideal duration for your Santa Cruz holiday depends on what you'd like to see. Typically, a few days to a week will give you time to hit all the top attractions and discover some hidden treasures along the way.
How to find the best Santa Cruz package deals?
Bagging a cheap Santa Cruz package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your budget, add some filters and browse what's available. You can personalise your search by "Amenities," "Property type," "Popular locations" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Cruz package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Cruz holiday as a package?
Expedia holiday packages are designed to help you keep more cash in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll usually land a better deal than booking each component individually. And you'll still enjoy the freedom to create a customised Santa Cruz holiday by choosing your preferred accommodation type, airline and car class.
When to book a holiday package to Santa Cruz?
If you're planning a spontaneous Santa Cruz trip, browse our last-minute deals that can be booked up to a week before you go. Don't want to leave things to the last minute? You can land incredible deals on your flights and hotels by booking ahead.
How to plan a trip to Santa Cruz?

  1. Choose your dates: The things you want to do in Santa Cruz and your favourite season can help you decide when to go.
  2. Set a budget: Consider expenses such as flights, food and transportation when calculating how much to put aside for your trip to Santa Cruz. Then, pick a hotel that matches your budget, whether that's an economical stay or a swankier retreat.
  3. Decide your trip length: Consider how much time you want to spend exploring Santa Cruz. Plan your itinerary so you can get to all the attractions and activities you're interested in without rushing.
  4. Combine your accommodation and airfare: Once you've nailed down your travel dates and duration, book the ideal Santa Cruz holiday package for you.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.