Southwest Illinois Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southwest Illinois hotels

Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,000 reviews)
"Great place to stay!"
United States
Tiffany
The price is €110
includes taxes & fees
19 Apr - 20 Apr
Holiday Inn Express & Suites Mount Vernon by IHG

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1,663 reviews)
"Beautiful hotel and loved the kickback and breakfast."
United States
Lori
The price is €100
includes taxes & fees
26 Apr - 27 Apr
Drury Plaza Hotel Mt. Vernon

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,025 reviews)
"Clean room, friendly staff, great rate, and great amenities. Would definitely stay again"
United States
Lisa
The price is €109
includes taxes & fees
12 Apr - 13 Apr
Comfort Suites Mount Vernon

Best Western Plus MidAmerica Hotel

Best Western Plus MidAmerica Hotel
2.5 star property
Mascoutah
9.0 out of 10, Wonderful, (1,000 reviews)
"Staff was great hotel was ckean and convenient to the airport ...would stay again "
United States
lisa
The price is €107
includes taxes & fees
30 Apr - 1 May
Best Western Plus MidAmerica Hotel

Ramada by Wyndham Vandalia

Ramada by Wyndham Vandalia
2.0 star property
Vandalia
7.8 out of 10, Good, (826 reviews)
"room to park truck and trailer, walmart close by"
United States
Mike
The price is €64
includes taxes & fees
12 Apr - 13 Apr
Ramada by Wyndham Vandalia

Best Western U. S. Inn

Best Western U. S. Inn
2.5 star property
Nashville
8.6 out of 10, Excellent, (412 reviews)
"The rooms were clean people were nice but for the price we paid they wasnt anything special"
United States
Samuel
The price is €112
includes taxes & fees
10 Apr - 11 Apr
Best Western U. S. Inn

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,007 reviews)
"Lovely hotel with exceptionally nice staff and clean and great room!"
United States
Eileen
The price is €67
includes taxes & fees
20 Apr - 21 Apr
Drury Inn & Suites Marion

Country Hearth Inn & Suites Edwardsville St. Louis

Country Hearth Inn & Suites Edwardsville St. Louis
2.5 star property
Edwardsville
8.6 out of 10, Excellent, (686 reviews)
"Room was great,staff friendly! All together a great stay."
United States
Zachary
The price is €137
includes taxes & fees
9 Apr - 10 Apr
Country Hearth Inn & Suites Edwardsville St. Louis

Hampton Inn O'Fallon

Hampton Inn O'Fallon
2.5 star property
O'Fallon
9.2 out of 10, Wonderful, (836 reviews)
"We had a peaceful, clean and friendly stay. Very nice location. "
United States
Carl
The price is €123
includes taxes & fees
12 Apr - 13 Apr
Hampton Inn O'Fallon

Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL
2.5 star property
Marion
8.6 out of 10, Excellent, (1,001 reviews)
"Very pet friendly."
United States
Mark
The price is €114
includes taxes & fees
12 Apr - 13 Apr
Country Inn & Suites by Radisson, Marion, IL

Holiday Inn Express & Suites Vandalia by IHG

Holiday Inn Express & Suites Vandalia by IHG
2.5 star property
Vandalia
8.8 out of 10, Excellent, (806 reviews)
"Easy access good breakfast "
United States
Jeff
The price is €98
includes taxes & fees
19 Apr - 20 Apr
Holiday Inn Express & Suites Vandalia by IHG

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL
3.0 star property
O'Fallon
9.6 out of 10, Exceptional, (1,001 reviews)
"Clean room, friendly staff, great food. "
United States
Pamela
The price is €105
includes taxes & fees
3 May - 4 May
Drury Inn & Suites St. Louis O'Fallon, IL

Comfort Inn & Suites Marion I-57

Comfort Inn & Suites Marion I-57
2.5 star property
Marion
9.4 out of 10, Exceptional, (1,002 reviews)
"Very nice hotel!"
United States
Dawn
The price is €122
includes taxes & fees
12 Apr - 13 Apr
Comfort Inn & Suites Marion I-57

Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
2.5 star property
Centralia
9.6 out of 10, Exceptional, (627 reviews)
"Great night stay"
United States
Sharisa
The price is €138
includes taxes & fees
9 Apr - 10 Apr
Best Western Plus Centralia Hotel & Suites

Super 8 by Wyndham Okawville

Super 8 by Wyndham Okawville
2.0 star property
Okawville
7.4 out of 10, Good, (326 reviews)
"The best hotel super 8 very very clean rooms, the staff friendly healthy breakfast The whole hotel was super clean and smelled nice I liked thanks "
Mexico
Jose
The price is €61
includes taxes & fees
14 Apr - 15 Apr
Super 8 by Wyndham Okawville

Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
4.5 star property
Carterville
9.4 out of 10, Exceptional, (424 reviews)
"Great place!"
United States
Paula
The price is €124
includes taxes & fees
13 Apr - 14 Apr
Walker's Bluff Casino Resort

The Principal Hotel

The Principal Hotel
3.5 star property
Columbia
9.8 out of 10, Exceptional, (228 reviews)
"I love staying here whenever i come to town."
United States
bonnie
The price is €107
includes taxes & fees
12 Apr - 13 Apr
The Principal Hotel

DoubleTree by Hilton Mt. Vernon

DoubleTree by Hilton Mt. Vernon
4.0 star property
Mount Vernon
8.4 out of 10, Very good, (798 reviews)
"Easy parking, clean hotel, great breakfast"
United States
Keni
The price is €123
includes taxes & fees
12 Apr - 13 Apr
DoubleTree by Hilton Mt. Vernon

Baymont by Wyndham Marion

Baymont by Wyndham Marion
2.5 star property
Marion
8.4 out of 10, Very good, (1,071 reviews)
"Really nice room for the price."
United States
Steve
The price is €88
includes taxes & fees
12 Apr - 13 Apr
Baymont by Wyndham Marion

Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia
2.5 star property
Columbia
8.6 out of 10, Excellent, (497 reviews)
"Clean and friendly staff "
United States
julie
The price is €107
includes taxes & fees
12 Apr - 13 Apr
Hampton Inn St. Louis - Columbia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Central United States attractions

Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

Photo by Carl Anderson
Open Photo by Carl Anderson

Top Southwest Illinois Hotel Reviews

More cheap stays in Southwest Illinois

Explore a world of travel with Expedia