Cheap flights from Antofagasta Region starting at €45

View €45 flight on Sat, 20 Dec 2025Opens in a new window

Popular airlines from Antofagasta Region

  • LATAM Airlines Group

    LATAM Airlines Group

  • Sky Airlines

    Sky Airlines

  • B & H Airlines

    B & H Airlines

  • American Airlines

    American Airlines

  • Delta

    Delta

  • Iberia

    Iberia

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 15% on select hotels after you book a flight*
  • payments icon

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheapest flights from Antofagasta Region

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Fri, 5 Sep - Mon, 8 Sep
ANF
Antofagasta
LSC
La Serena
€73 Return, found 6 days ago
€73
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Fri, 5 Sep from Antofagasta to La Serena, returning Mon, 8 Sep, priced at €73 found 6 days ago
LATAM Airlines Group
Sat, 6 Sep - Sun, 7 Sep
ANF
Antofagasta
SCL
Santiago
€90 Return, found 2 days ago
€90
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Sat, 6 Sep from Antofagasta to Santiago, returning Sun, 7 Sep, priced at €90 found 2 days ago
LATAM Airlines Group
Fri, 3 Oct - Sun, 5 Oct
CJC
Calama
SCL
Santiago
€91 Return, found 4 days ago
€91
Return
found 4 days ago
Select LATAM Airlines Group flight, departing Fri, 3 Oct from Calama to Santiago, returning Sun, 5 Oct, priced at €91 found 4 days ago
LATAM Airlines Group
Sat, 27 Sep - Sun, 28 Sep
CJC
Calama
SCL
Santiago
€92 Return, found 6 days ago
€92
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, 27 Sep from Calama to Santiago, returning Sun, 28 Sep, priced at €92 found 6 days ago
LATAM Airlines Group
Fri, 3 Oct - Sun, 5 Oct
CJC
Calama
SCL
Santiago
€98 Return, found 4 days ago
€98
Return
found 4 days ago
Select LATAM Airlines Group flight, departing Fri, 3 Oct from Calama to Santiago, returning Sun, 5 Oct, priced at €98 found 4 days ago
LATAM Airlines Group
Sat, 13 Sep - Sun, 14 Sep
ANF
Antofagasta
SCL
Santiago
€99 Return, found 3 days ago
€99
Return
found 3 days ago
Select LATAM Airlines Group flight, departing Sat, 13 Sep from Antofagasta to Santiago, returning Sun, 14 Sep, priced at €99 found 3 days ago
LATAM Airlines Group
Thu, 2 Oct - Sun, 5 Oct
ANF
Antofagasta
SCL
Santiago
€102 Return, found 6 days ago
€102
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, 2 Oct from Antofagasta to Santiago, returning Sun, 5 Oct, priced at €102 found 6 days ago
LATAM Airlines Group
Sat, 6 Sep - Sun, 7 Sep
ANF
Antofagasta
SCL
Santiago
€102 Return, found 2 days ago
€102
Return
found 2 days ago
Select LATAM Airlines Group flight, departing Sat, 6 Sep from Antofagasta to Santiago, returning Sun, 7 Sep, priced at €102 found 2 days ago
LATAM Airlines Group
Fri, 3 Oct - Sun, 5 Oct
CJC
Calama
SCL
Santiago
€103 Return, found 4 days ago
€103
Return
found 4 days ago
Select LATAM Airlines Group flight, departing Fri, 3 Oct from Calama to Santiago, returning Sun, 5 Oct, priced at €103 found 4 days ago
LATAM Airlines Group
Fri, 26 Sep - Sun, 28 Sep
CJC
Calama
SCL
Santiago
€105 Return, found 1 day ago
€105
Return
found 1 day ago
Select LATAM Airlines Group flight, departing Fri, 26 Sep from Calama to Santiago, returning Sun, 28 Sep, priced at €105 found 1 day ago
*Available to Expedia members.