Cheap flights from Antofagasta Region starting at €42

View €42 flight on Tue, 8 Dec 2026Opens in a new window

Popular airlines from Antofagasta Region

  • LATAM Airlines Group

  • B & H Airlines

  • Sky Airlines

  • Iberia

  • American Airlines

  • Delta

  • Qantas Airways

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 15% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheapest flights from Antofagasta Region

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Sat, 20 Jun - Sun, 21 Jun
CJC
Calama
SCL
Santiago
€77 Return, found 5 days ago
€77
Return
found 5 days ago
Select Jetsmart SPA flight, departing Sat, 20 Jun from Calama to Santiago, returning Sun, 21 Jun, priced at €77 found 5 days ago
Jetsmart SPA
Tue, 6 Oct - Wed, 7 Oct
ANF
Antofagasta
SCL
Santiago
€100 Return, found 1 day ago
€100
Return
found 1 day ago
Select Jetsmart SPA flight, departing Tue, 6 Oct from Antofagasta to Santiago, returning Wed, 7 Oct, priced at €100 found 1 day ago
Jetsmart SPA
Thu, 2 Jul - Sun, 5 Jul
CJC
Calama
SCL
Santiago
€100 Return, found 1 hour ago
€100
Return
found 1 hour ago
Select Jetsmart SPA flight, departing Thu, 2 Jul from Calama to Santiago, returning Sun, 5 Jul, priced at €100 found 1 hour ago
Jetsmart SPA
Tue, 6 Oct - Wed, 7 Oct
ANF
Antofagasta
SCL
Santiago
€110 Return, found 1 day ago
€110
Return
found 1 day ago
Select Jetsmart SPA flight, departing Tue, 6 Oct from Antofagasta to Santiago, returning Wed, 7 Oct, priced at €110 found 1 day ago
LATAM Airlines Group
Sat, 20 Jun - Sun, 21 Jun
CJC
Calama
SCL
Santiago
€116 Return, found 5 days ago
€116
Return
found 5 days ago
Select LATAM Airlines Group flight, departing Sat, 20 Jun from Calama to Santiago, returning Sun, 21 Jun, priced at €116 found 5 days ago
LATAM Airlines Group
Tue, 6 Oct - Wed, 7 Oct
ANF
Antofagasta
SCL
Santiago
€120 Return, found 1 day ago
€120
Return
found 1 day ago
Select LATAM Airlines Group flight, departing Tue, 6 Oct from Antofagasta to Santiago, returning Wed, 7 Oct, priced at €120 found 1 day ago
LATAM Airlines Group
Tue, 6 Oct - Wed, 7 Oct
ANF
Antofagasta
SCL
Santiago
€130 Return, found 1 day ago
€130
Return
found 1 day ago
Select LATAM Airlines Group flight, departing Tue, 6 Oct from Antofagasta to Santiago, returning Wed, 7 Oct, priced at €130 found 1 day ago
Jetsmart SPA
Thu, 2 Jul - Sun, 5 Jul
CJC
Calama
SCL
Santiago
€131 Return, found 1 hour ago
€131
Return
found 1 hour ago
Select Jetsmart SPA flight, departing Thu, 2 Jul from Calama to Santiago, returning Sun, 5 Jul, priced at €131 found 1 hour ago
LATAM Airlines Group
Tue, 6 Oct - Wed, 7 Oct
ANF
Antofagasta
SCL
Santiago
€133 Return, found 1 day ago
€133
Return
found 1 day ago
Select LATAM Airlines Group flight, departing Tue, 6 Oct from Antofagasta to Santiago, returning Wed, 7 Oct, priced at €133 found 1 day ago
LATAM Airlines Group
Tue, 6 Oct - Wed, 7 Oct
ANF
Antofagasta
SCL
Santiago
€143 Return, found 1 day ago
€143
Return
found 1 day ago
Select LATAM Airlines Group flight, departing Tue, 6 Oct from Antofagasta to Santiago, returning Wed, 7 Oct, priced at €143 found 1 day ago

Explore a world of travel with Expedia

*Available to Expedia members.