Romantic Holidays in Upstate South Carolina 2026

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Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Seneca SC

22 min drive from Clemson University

Stay at this cabin in Seneca. Enjoy free Wi-Fi, a fitness centre and a garden. Popular attractions Lake Keowee and South Cove Park are located nearby.

Peaceful Oasis Convenient to Greenville!

Simpsonville SC

2 hours drive from Clemson University

Stay at this holiday home in Simpsonville. Enjoy a water park, a garden and laundry facilities. Popular attractions LeMans Karting and Frankie's Fun Park are ...

10/10 Exceptional! (115 reviews)

"Pet friendly"

Reviewed on 24 May 2026

Greenville Marriott

One Parkway E Greenville SC

2 hours drive from Clemson University

Stay at this business-friendly hotel in Greenville. Enjoy free parking, breakfast (surcharge) and a free airport shuttle. Our guests praise the helpful staff ...

8.6/10 Excellent! (705 reviews)

"We booked a king room and got a two double room unfortunately. Otherwise the place was great."

Reviewed on 29 Sept 2026

See all 3,086 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.