Romantic Holidays in Southwest Houston 2026

Plan, book, travel with confidence
Better together
Save up to €900 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Hotel Granduca Houston

1080 Uptown Park Blvd Houston TX

9 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 bars/lounges and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

The Greenleigh, River Oaks, Autograph Collection

2525 West Loop S Houston TX

6 min drive from MD Anderson Cancer Center

Stay at this hotel in Houston. Enjoy free Wi-Fi, room service and valet parking (surcharge). Our guests praise the clean rooms in their reviews. Popular attractions ...

5.8/10 (1,000 reviews)

"The shower didn’t work, no hot water, I paid a deposit November 8 & here it is December 7th still no refund. The transaction shows pending. They all act like they don’t know what’s what ! They use to be upscale now they are 1/10 highly do NOT recommend"

Reviewed on 7 Dec 2024

Omni Houston Hotel

4 Riverway Houston TX

9 min drive from MD Anderson Cancer Center

Stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa and 3 bars/lounges. Our guests praise the helpful staff in their reviews. Popular ...

9.2/10 Wonderful! (1,003 reviews)

Couples like: full-service spa, couples spa treatments, bar, hot tub

Travelers say...

"Always a quality stay with excellent amenities and friendly staff."

Reviewed on 17 Aug 2026

See all 1,336 properties in Southwest Houston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.