St. Louis Hotel Guide - James S. McDonnell Prologue Room hotels in St. Louis, United States of America.

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Check prices for these dates

Tonight
19 Dec - 20 Dec
Tomorrow
20 Dec - 21 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for James S. McDonnell Prologue Room hotels

Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
2.6 km from James S. McDonnell Prologue Room
9.4 out of 10, Exceptional, (2748)
"Great place to stay before your early morning flight. "
United States
Henry
The price is €90
includes taxes & fees
23 Dec - 24 Dec
Pear Tree Inn St. Louis Airport
Exterior
Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport
3.0 star property
2 km from James S. McDonnell Prologue Room
9.2 out of 10, Wonderful, (1100)
"Very friendly staff, and excellent customer service "
United States
Breneda
The price is €106
includes taxes & fees
24 Dec - 25 Dec
Drury Inn & Suites St. Louis Airport
Free daily continental breakfast
Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport
2.5 star property
2.5 km from James S. McDonnell Prologue Room
9.2 out of 10, Wonderful, (1504)
"The room was very clean and the staff was very helpful."
United States
John
The price is €108
includes taxes & fees
1 Jan - 2 Jan 2026
Wingate by Wyndham St. Louis Airport
Restaurant
Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport
2.5 star property
2 km from James S. McDonnell Prologue Room
8.8 out of 10, Excellent, (103)
"Great stay for the night before our trip"
United States
April
The price is €124
includes taxes & fees
1 Jan - 2 Jan 2026
Hampton Inn By Hilton St Louis Airport
Free daily buffet breakfast
Holiday Inn Express & Suites St Louis Airport by IHG

Holiday Inn Express & Suites St Louis Airport by IHG

Holiday Inn Express & Suites St Louis Airport by IHG
2.5 star property
2 km from James S. McDonnell Prologue Room
8.6 out of 10, Excellent, (1001)
"Room was okay and help friendly"
United States
Jeffery
The price is €124
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express & Suites St Louis Airport by IHG
Meeting facility
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel
4.0 star property
Berkeley, 2.1 km from James S. McDonnell Prologue Room
8.4 out of 10, Very good, (1055)
"Staff was courteous and the room was clean."
United States
Mia
The price is €118
includes taxes & fees
2 Jan - 3 Jan 2026
Renaissance St. Louis Airport Hotel
Restaurant
Marriott St. Louis Airport

Marriott St. Louis Airport

Marriott St. Louis Airport
4.0 star property
2.4 km from James S. McDonnell Prologue Room
8.0 out of 10, Very good, (1001)
"Love that there is a restaurant inside the property so that after you check in you do not have to go elsewhere to find a place to eat. "
United States
Susan
The price is €125
includes taxes & fees
26 Dec - 27 Dec
Marriott St. Louis Airport
Bar (on property)
Hilton St. Louis Airport

Hilton St. Louis Airport

Hilton St. Louis Airport
3.5 star property
1.9 km from James S. McDonnell Prologue Room
7.6 out of 10, Good, (1008)
"Great stay"
United States
Robert
The price is €117
includes taxes & fees
27 Dec - 28 Dec
Hilton St. Louis Airport
Snack bar
DoubleTree by Hilton St. Louis Airport

DoubleTree by Hilton St. Louis Airport

DoubleTree by Hilton St. Louis Airport
4.0 star property
2.1 km from James S. McDonnell Prologue Room
7.8 out of 10, Good, (863)
"Quick and courteous checkin, clean and quiet room"
United States
Jane
The price is €102
includes taxes & fees
22 Dec - 23 Dec
DoubleTree by Hilton St. Louis Airport
Superior Double Room
St. Louis Airport Hotel

St. Louis Airport Hotel

St. Louis Airport Hotel
3.5 star property
Berkeley, 2.5 km from James S. McDonnell Prologue Room
7.4 out of 10, Good, (984)
"Clean room, quiet, easy parking, convenient"
United States
Angela and Stephon
The price is €64
includes taxes & fees
24 Dec - 25 Dec
St. Louis Airport Hotel
Breakfast area
Quality Inn Florissant - St Louis

Quality Inn Florissant - St Louis

Quality Inn Florissant - St Louis
2.5 star property
3.1 km from James S. McDonnell Prologue Room
7.6 out of 10, Good, (999)
"No microwave in all the rooms"
United States
James
The price is €67
includes taxes & fees
25 Dec - 26 Dec
Quality Inn Florissant - St Louis
Exterior
Travelodge by Wyndham St. Louis

Travelodge by Wyndham St. Louis

Travelodge by Wyndham St. Louis
2.0 star property
Berkeley, 2.4 km from James S. McDonnell Prologue Room
6.6 out of 10, (1002)
"It was a nice and cheap stay"
United States
Levi
The price is €61
includes taxes & fees
11 Jan - 12 Jan 2026
Travelodge by Wyndham St. Louis
Blackout curtains, free WiFi, bed sheets
HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh

HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh

HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh
2.0 star property
2.9 km from James S. McDonnell Prologue Room
5.6 out of 10, (1000)
"Staff is so helpful and fridndly and the rooms re always clean. I wouldnt want to stay anywhere else."
United States
Samuel
The price is €78
includes taxes & fees
31 Dec - 1 Jan 2026
HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh
Lobby
Welcome Suites Hazelwood

Welcome Suites Hazelwood

Welcome Suites Hazelwood
2.5 star property
3 km from James S. McDonnell Prologue Room
5.4 out of 10, (245)
"Clean rooms, full kitchens, they are currently updating everything, best prices in the area! Also the staff are great! "
United States
Lindsay
The price is €73
includes taxes & fees
3 Jan - 4 Jan 2026
Welcome Suites Hazelwood
Desk, laptop workspace, soundproofing, iron/ironing board
Quality Inn Saint Louis Airport

Quality Inn Saint Louis Airport

Quality Inn Saint Louis Airport
2.5 star property
2 km from James S. McDonnell Prologue Room
6.2 out of 10, (1004)
"Room not spotless but clean enough, staff courteous "
United States
Wynne
The price is €53
includes taxes & fees
11 Jan - 12 Jan 2026
Quality Inn Saint Louis Airport
Lobby
Hilton Garden Inn St. Louis Airport

Hilton Garden Inn St. Louis Airport

Hilton Garden Inn St. Louis Airport
3.0 star property
Berkeley, 3.7 km from James S. McDonnell Prologue Room
8.4 out of 10, Very good, (1000)
"Loved it very quiet and inviting love watching the snow during thanksgiving weekend."
United States
Julia
The price is €114
includes taxes & fees
26 Dec - 27 Dec
Hilton Garden Inn St. Louis Airport
Indoor pool
Comfort Inn & Suites St. Louis - Hazelwood

Comfort Inn & Suites St. Louis - Hazelwood

Comfort Inn & Suites St. Louis - Hazelwood
2.5 star property
3.4 km from James S. McDonnell Prologue Room
7.8 out of 10, Good, (605)
"Room was clean staff was friendly "
United States
Ella
The price is €83
includes taxes & fees
22 Dec - 23 Dec
Comfort Inn & Suites St. Louis - Hazelwood
Lobby
Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO
2.0 star property
4.6 km from James S. McDonnell Prologue Room
8.4 out of 10, Very good, (1623)
"great stay."
United States
Allison
The price is €62
includes taxes & fees
1 Jan - 2 Jan 2026
Motel 6 Hazelwood, MO
Lobby
Comfort Inn St. Louis Airport

Comfort Inn St. Louis Airport

Comfort Inn St. Louis Airport
3.0 star property
4.7 km from James S. McDonnell Prologue Room
8.4 out of 10, Very good, (937)
"Extremely clean hotel! Very friendly staff. Enjoyed my 15 days there."
United States
Warnetta
The price is €86
includes taxes & fees
29 Dec - 30 Dec
Comfort Inn St. Louis Airport
Exterior
Best Western St. Louis Airport North Hotel & Suites

Best Western St. Louis Airport North Hotel & Suites

Best Western St. Louis Airport North Hotel & Suites
2.5 star property
3.6 km from James S. McDonnell Prologue Room
7.4 out of 10, Good, (862)
"Friendly front desk"
United States
Phillip
The price is €79
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western St. Louis Airport North Hotel & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top James S. McDonnell Prologue Room Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Everything was great, rooms were clean smelled great. Staff was super friendly and accommodating. Good value good environment highly recommend."
robert 1-night trip
Posted 1 day ago
Pear Tree Inn St. Louis Airport

Hotels near other James S. McDonnell Prologue Room attractions

Blacks in Flight Mural

You can enjoy some culture when you stop by Blacks in Flight Mural in St. Louis. Experience the area's acclaimed art galleries and great live music.
See properties

Bigfoot 4 x 4 Inc

2.6/5 (19 reviews)
You can spend time browsing the exhibits at Bigfoot 4 x 4 Inc in Hazelwood. Experience the great live music and acclaimed theatre scene in this family-friendly area.
See properties

Frequently asked questions

What's the area like around James S. McDonnell Prologue Room?
James S. McDonnell Prologue Room is located in a welcoming area of St. Louis known for its array of dining options and sporting events. You'll find 106 hotels and other accommodations within a few miles for a convenient home base.
Where is the best place to stay close to James S. McDonnell Prologue Room?
Hilton St. Louis Airport is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and a 24-hour fitness centre. It's located 1.2 mi (1.9 km) from James S. McDonnell Prologue Room. Other good choices within a few miles include Renaissance St. Louis Airport Hotel and Pear Tree Inn St. Louis Airport.
How many hotels will I be able to find near James S. McDonnell Prologue Room?
Expedia has 106 hotels and other accommodation options a few miles from James S. McDonnell Prologue Room.
If I need to cancel the hotel reservation for my stay near James S. McDonnell Prologue Room, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the best options available near James S. McDonnell Prologue Room.
What can I see and do near James S. McDonnell Prologue Room?
Payne-Gentry Historical House, St. Louis Car Museum and Museum of Transportation feature a variety of fascinating exhibits to see while you're in town. Attractions like Blanche M. Touhill Performing Arts Center and Blacks in Flight Mural highlight the local culture. Bigfoot 4 x 4 Inc, Old St. Ferdinand Shrine and St. Louis Mercantile Library are a few additional nearby sights.