Uptown - Upper Duval

Key West

Key West Butterfly and Nature Conservatory featuring animals, flowers and zoo animals
Key West Butterfly and Nature Conservatory featuring flowers, zoo animals and animals
South Beach showing a sandy beach and a coastal town as well as a large group of people
South Beach showing a sandy beach, swimming and a luxury hotel or resort
Key West Butterfly and Nature Conservatory showing signage

Popular places to visit

Southernmost Point

Southernmost Point

4/5(39 reviews)

Snap a memorable photograph from the edge of North America at this monumental landmark.

Southernmost Point
South Beach

South Beach

4.5/5(8 reviews)

The southernmost beach in the continental United States is a convenient sandy enclave, just minutes from the center of town.

South Beach
Key West Butterfly and Nature Conservatory showing food, animals and zoo animals

Key West Butterfly and Nature Conservatory

4.5/5(10 reviews)

With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.

Key West Butterfly and Nature Conservatory

Things to do

Florida: Key West Overseas Highway Self-Driving Tour

Florida: Key West Overseas Highway App-Based Driving Audio Tour

€16
per traveller
76% of travellers recommend
Florida: Key West Overseas Highway App-Based Driving Audio Tour
Bahama Village Walking Tour

Bahama Village Walking Tour

€26
per adult
Bahama Village Walking Tour
Key West’s Old Town Treasures: A Self-Guided Audio Tour

Key West’s Old Town Treasures: A Self-Guided Audio Tour

€13
per adult
Key West’s Old Town Treasures: A Self-Guided Audio Tour
Key West History And Culture Walking Tour

Southernmost Key West History and Culture Small-Group Walking Tour

€37
per adult
Southernmost Key West History and Culture Small-Group Walking Tour
Southernmost Point in the Continental USA!

PRIVATE Welcome to Key West Walking Tour

€242
per adult
PRIVATE Welcome to Key West Walking Tour
An Audio Guide of Key West’s Journey From Village to Micro State

An Audio Guide of Key West’s Journey From Village to Micro State

€11
per adult
An Audio Guide of Key West’s Journey From Village to Micro State
See all activities in Key West

Top hotels in Uptown - Upper Duval

Southernmost Beach Resort
Southernmost Beach Resort
4 out of 5
1319 Duval Street, Key West, FL
The price is €342 per night from 11 May to 12 May
€342
includes taxes & fees
11 May - 12 May
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,434 reviews)
"Beautiful property, friendly staff, and great location."

Reviewed on 23 Apr 2025

Southernmost Beach Resort
The Reach Key West, Curio Collection by Hilton
The Reach Key West, Curio Collection by Hilton
4 out of 5
1435 Simonton Street, Key West, FL
Fully refundable
The price is €329 per night from 14 May to 15 May
€329
includes taxes & fees
14 May - 15 May
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.2/10 Very Good! (938 reviews)
"It was a very pleasant and relaxing stay"

Reviewed on 18 Apr 2025

The Reach Key West, Curio Collection by Hilton
The Southernmost Inn - Adults Only
The Southernmost Inn - Adults Only
3 out of 5
525 United Street, Key West, FL
The price is €216 per night from 30 Apr to 1 May
€216
includes taxes & fees
30 Apr - 1 May
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8/10 Very Good! (1,052 reviews)
"We have been staying with The Southernmost Inn adults only for many years. The staff is top notch and will do anything they can to help you with your accommodations. They have helped us switch rooms after we arrived and realized I got my booking wrong. I now call the resort directly for accommodations ..."

Reviewed on 23 Apr 2025

The Southernmost Inn - Adults Only
Southwinds Motel
Southwinds Motel
2 out of 5
1321 Simonton Street, Key West, FL
The price is €206 per night from 26 May to 27 May
€206
includes taxes & fees
26 May - 27 May
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,099 reviews)
"Such nice staff! Great area! Everything you need is a short walk away. Includes access to a beach with chairs and towels too!"

Reviewed on 20 Apr 2025

Southwinds Motel
Douglas House
Douglas House
3 out of 5
419 Amelia St, Key West, FL
The price is €204 per night from 29 Apr to 30 Apr
€204
includes taxes & fees
29 Apr - 30 Apr
Stay at this 3-star guesthouse in Key West. Enjoy free WiFi, free parking, and daily housekeeping. Popular attractions Duval Street and Ernest Hemingway Home ...
9.4/10 Exceptional! (71 reviews)
"Excellent!"

Reviewed on 24 Apr 2025

Douglas House
Orchid Key Inn - Adults Only
Orchid Key Inn - Adults Only
3.5 out of 5
1004 Duval St, Key West, FL
The price is €407 per night from 28 Apr to 29 Apr
€407
includes taxes & fees
28 Apr - 29 Apr
Stay at this 3.5-star hotel in Key West. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
9.8/10 Exceptional! (1,000 reviews)
"Very nice place"

Reviewed on 12 Apr 2025

Orchid Key Inn - Adults Only
See all 2,915 properties in Uptown - Upper Duval
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Uptown - Upper Duval

Default Image

Old Town Key West

5/5(6 area reviews)

While visiting Old Town Key West, you might make a stop by sights like Duval Street and Saint Mary Star of the Sea.

Old Town Key West
Default Image

Downtown Key West

While visiting Downtown Key West, you might make a stop by sights like Duval Street and Ernest Hemingway Home and Museum.

Downtown Key West
Harry S. Truman Little White House which includes a house and cycling

Bahama Village

5/5(1 area review)

Bahama Village is noteworthy for its historical sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.

Bahama Village
Default Image

Casa Marina

While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.

Casa Marina
Default Image

Key West Historic District

4.5/5(66 area reviews)

Travellers to Key West Historic District praise its fantastic nightlife. If you've got some more time to explore, be sure to stop by Duval Street and Saint Mary Star of the Sea.

Key West Historic District
Default Image

White Street Gallery District

If you're looking for some top things to see and do in White Street Gallery District and surrounding area, you can visit Duval Street and Saint Mary Star of the Sea.

White Street Gallery District

Uptown - Upper Duval

Choose two or more items and save on your trip: