Hotels closest to Mayo Clinic in Rochester

A historic building with a prominent tower, two American flags, and a modern glass structure in the foreground.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Mayo Clinic hotels

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern restaurant with a counter, seating area, and a TV screen.

A modern hotel room with a bed, desk, and kitchenette.

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

howard

€113

includes taxes & fees

7 Nov - 8 Nov

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

2. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Brien

€119

includes taxes & fees

6 Nov - 7 Nov

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

3. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Chee

€136

includes taxes & fees

13 Nov - 14 Nov

A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.

A modern hotel entrance with a glass facade, a covered entrance area, and a visible 'Hilton' sign.

A spacious lobby with a curved staircase, comfortable seating areas, and large windows offering views of the outdoors.

A spacious lobby with modern furniture, a staircase, and large windows.

4. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Jennifer

€183

includes taxes & fees

7 Nov - 8 Nov

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

5. The Berkman

Folwell, 1.4 km from Mayo Clinic

Suzette

€197

includes taxes & fees

21 Nov - 22 Nov

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

A hotel room with a bed, bedside table, and a window with curtains.

6. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Cory

€141

includes taxes & fees

6 Nov - 7 Nov

A modern indoor patio with a fire feature, seating, and large windows.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

James

€125

includes taxes & fees

6 Nov - 7 Nov

A modern living room with a fireplace, comfortable seating, and large windows.

A modern interior with a seating area, a bookshelf, and a view through large windows.

A modern hotel entrance with a glass facade, a staircase leading to the entrance, and a sign for Staybridge Suites.

A modern hotel room with a kitchen area, a dining table with chairs, a sofa, and a TV mounted on the wall.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Amanda

€110

includes taxes & fees

25 Nov - 26 Nov

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

9. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Ashley

€67

includes taxes & fees

15 Nov - 16 Nov

A modern bathroom with a granite countertop sink, a large mirror, and a shower area.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

€113

includes taxes & fees

25 Nov - 26 Nov

A hotel with a stone facade, multiple windows, and a sign indicating it is Candlewood Suites.

A hotel lobby with a reception desk, seating area, and a large window.

A hotel gym with treadmills, elliptical machines, and free weights.

A hotel room with a dining area, a sofa, a TV, and a bed.

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Kevin

€110

includes taxes & fees

15 Nov - 16 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

12. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

dennis

€100

includes taxes & fees

1 Nov - 2 Nov

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A conference room with a long table, multiple chairs, and decorative wall art.

A modern kitchen with a built-in dishwasher, a coffee maker, a microwave, and a sink.

13. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

€106

includes taxes & fees

6 Nov - 7 Nov

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

An indoor swimming pool with a clock on the wall, lounge chairs, and a lifeguard warning sign.

14. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Jennifer

€174

includes taxes & fees

7 Nov - 8 Nov

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern bar area with seating and a counter.

A modern indoor pool area with lounge chairs and a pool.

15. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Arlan

€131

includes taxes & fees

13 Nov - 14 Nov

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

A hotel room with a large bed, a TV, a bathroom with a sink and mirror, and a window with curtains.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

16. Aspen Suites

1.2 km from Mayo Clinic

Douangta

€145

includes taxes & fees

31 Oct - 1 Nov

A spacious outdoor dining area with multiple tables and chairs, large windows, and a wooden ceiling structure.

An outdoor dining area with wooden beams, tables, and chairs.

A modern interior with a bar area, seating, and a large window.

A modern hotel building with a prominent sign for 'Hotel Indigo' and a 'Crave Drink' establishment.

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

Naomi

€106

includes taxes & fees

14 Nov - 15 Nov

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A reception area with a curved counter, ceiling lights, and a potted plant.

18. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Elaine

€123

includes taxes & fees

29 Oct - 30 Oct

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A reception area with two counters, a patterned wall, and a wooden floor.

19. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

Richard

€121

includes taxes & fees

7 Nov - 8 Nov

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

20. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Jessica

€72

includes taxes & fees

7 Nov - 8 Nov

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,001 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 748 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 319 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 654 reviews	View
The Berkman	9.6 Exceptional 451 reviews	View

Hotels recommended for families near Mayo Clinic

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

€106

includes taxes & fees

14 Nov - 15 Nov

Brentwood Inn & Suites

Downtown Rochester

€123

includes taxes & fees

29 Oct - 30 Oct

A swimming pool with a glass ceiling, a neon sign for the KAFFLER HOTEL, and a view of the city skyline at dusk.

A bar area with a long counter, multiple bar stools, and a television mounted above the bar.

A banquet hall with round tables, chairs, chandeliers, and a fireplace.

A hotel room with a large bed, a desk, a chair, a microwave, and a framed picture on the wall.

Kahler Grand Hotel

Downtown Rochester

€151

includes taxes & fees

28 Oct - 29 Oct

Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

€131

includes taxes & fees

13 Nov - 14 Nov

A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.

A reception area with a wooden reception desk, a clock, and a wall-mounted display.

A restaurant with a bar area, wooden chairs, and a stone wall.

A modern building with large windows and a parking lot.

Kahler Inn and Suites - Mayo Clinic Area

Downtown Rochester

€129

includes taxes & fees

31 Oct - 1 Nov

Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester

€174

includes taxes & fees

7 Nov - 8 Nov

Aspen Suites

Rochester

€145

includes taxes & fees

31 Oct - 1 Nov

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

€141

includes taxes & fees

6 Nov - 7 Nov

Top Mayo Clinic Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"The room had some noise like water going thru some pipes during the early morning hours. Could be something due to the swimming pool. No sleep after that started."

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Staff was extremely helpful and knowledgeable. Restaurant was clean and food was great. Very close to everything and parking was easy and inexpensive."

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"B"

Brentwood Inn & Suites

8/10 Good

"While the property is old, I found it very clean. Location is excellent. Bed was not great. Staff was incredibly accommodating."

Broadway Plaza, Trademark Collection by Wyndham

10/10 Excellent

"The property had two bathrooms which was a nice surprise. The kitchen had a full size refrigerator, dishwasher, and laundry machine. The room also had a very pleasant air freshener smell and the bathroom had night lights so you didn'thave to turn on the bathroom's big light in during the night. Thank you for making our stay so pleasant."

Hilton Garden Inn Rochester Downtown, MN

10/10 Excellent

"The staff was very helpful. Our room was very clean. Loved how easy it was to get to the Mayo Clinic."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 153 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels should I expect to find near Mayo Clinic?

Expedia has 153 hotels and other accommodation options within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Rochester Hotel Guide - Mayo Clinic hotels in Rochester, United States of America.

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic hotels

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

3. Residence Inn by Marriott Rochester Mayo Clinic Area South

4. Hilton Rochester Mayo Clinic Area

5. The Berkman

6. TownePlace Suites by Marriott Rochester Mayo Clinic Area

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. Econo Lodge Mayo Clinic Area

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

12. Hampton Inn Rochester-South

13. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

14. Broadway Plaza, Trademark Collection by Wyndham

15. Hyatt House Rochester/Mayo Clinic Area

16. Aspen Suites

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

18. Brentwood Inn & Suites

19. Hilton Garden Inn Rochester Downtown, MN

20. Quality Inn & Suites Mayo Clinic Area

Compare popular hotels close to Mayo Clinic

Hotels recommended for families near Mayo Clinic

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Brentwood Inn & Suites

Kahler Grand Hotel

Hyatt House Rochester/Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

Broadway Plaza, Trademark Collection by Wyndham

Aspen Suites

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Top Mayo Clinic Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hyatt House Rochester/Mayo Clinic Area

Brentwood Inn & Suites

Broadway Plaza, Trademark Collection by Wyndham

Hilton Garden Inn Rochester Downtown, MN

Frequently asked questions

Explore a world of travel with Expedia