Plummer Building at Sunrise

Rochester Hotel Guide - Mayo Clinic hotels in Rochester, United States of America.

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mayo Clinic hotels

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
9.6 out of 10, Exceptional, (608 reviews)
"Convenient, short walk to Mayo and two excellent restaurants."
United States
Jerome
The price is €170
includes taxes & fees
3 Jul - 4 Jul
Hilton Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Kutzky Park, 0.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (536 reviews)
"Great place to stay"
United States
Brian
The price is €127
includes taxes & fees
4 Jul - 5 Jul
TownePlace Suites by Marriott Rochester Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park, 1 km from Mayo Clinic
9.4 out of 10, Exceptional, (1,013 reviews)
"Great stay"
United States
Samantha
The price is €129
includes taxes & fees
5 Jul - 6 Jul
EVEN Hotel Rochester - Mayo Clinic Area by IHG

The Berkman

The Berkman
3.0 star property
Folwell, 1.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (416 reviews)
"Great stay"
United States
Kayla
The price is €217
includes taxes & fees
22 Jun - 23 Jun
The Berkman

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
3.0 star property
Kutzky Park, 1 km from Mayo Clinic
9.4 out of 10, Exceptional, (486 reviews)
"Great stay!"
United States
Kristina
The price is €124
includes taxes & fees
12 Jul - 13 Jul
Staybridge Suites Rochester - Mayo Clinic Area by IHG

The Towers At Kahler Grand Hotel

The Towers At Kahler Grand Hotel
4.0 star property
Downtown Rochester, 0.1 km from Mayo Clinic
9.4 out of 10, Exceptional, (106 reviews)
"wOW! Couldn't be better"
United States
Jeanne
The price is €398
includes taxes & fees
9 Jul - 10 Jul
The Towers At Kahler Grand Hotel

Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
2.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (287 reviews)
"Great stay."
United States
Engen
The price is €138
includes taxes & fees
28 Jun - 29 Jun
Residence Inn by Marriott Rochester Mayo Clinic Area South

Candlewood Suites Rochester Mayo Clinic Area by IHG

Candlewood Suites Rochester Mayo Clinic Area by IHG
2.5 star property
2.6 km from Mayo Clinic
9.4 out of 10, Exceptional, (498 reviews)
"Friendly staff and clean suite"
United States
Cindy
The price is €101
includes taxes & fees
3 Jul - 4 Jul
Candlewood Suites Rochester Mayo Clinic Area by IHG

Brentwood Inn & Suites

Brentwood Inn & Suites
2.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (1,005 reviews)
"very clean and friendly staff"
United States
Ed
The price is €98
includes taxes & fees
26 Jun - 27 Jun
Brentwood Inn & Suites

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park, 1.4 km from Mayo Clinic
9.2 out of 10, Wonderful, (799 reviews)
"The staff here is great Cozy restaurant."
United States
MATTHEW
The price is €109
includes taxes & fees
13 Jun - 14 Jun
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester, 0.5 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,014 reviews)
"Great room and good breakfast!"
United States
Bridgett
The price is €168
includes taxes & fees
13 Jun - 14 Jun
Hyatt House Rochester/Mayo Clinic Area

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (912 reviews)
"Nice hotel near mayo. "
United States
Rob
The price is €121
includes taxes & fees
12 Jul - 13 Jul
Hilton Garden Inn Rochester Downtown, MN

Aspen Suites

Aspen Suites
3.0 star property
1.2 km from Mayo Clinic
9.0 out of 10, Wonderful, (856 reviews)
"Great place to stay near downtown!! Breakfast was good and the hotel room was very clean!"
United States
Rhianon
The price is €139
includes taxes & fees
28 Jun - 29 Jun
Aspen Suites

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester, 0.4 km from Mayo Clinic
8.8 out of 10, Excellent, (1,014 reviews)
"As always it was a wonderful stay!"
United States
Misty
The price is €111
includes taxes & fees
20 Jun - 21 Jun
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
3.1 km from Mayo Clinic
9.0 out of 10, Wonderful, (998 reviews)
"Stay here each trip to Mayo.Reliable,love the area"
United States
William
The price is €73
includes taxes & fees
5 Jul - 6 Jul
Econo Lodge Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3.0 star property
Historic Southwest, 0.6 km from Mayo Clinic
8.6 out of 10, Excellent, (1,023 reviews)
"Very affordable we were visiting family overall stay was prefect"
United States
James
The price is €113
includes taxes & fees
13 Jun - 14 Jun
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Kahler Grand Hotel

Kahler Grand Hotel
3.0 star property
Downtown Rochester, 0.1 km from Mayo Clinic
8.4 out of 10, Very good, (2,153 reviews)
"Staff were great"
United States
CARLOS
The price is €132
includes taxes & fees
12 Jul - 13 Jul
Kahler Grand Hotel

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
3.0 star property
Kutzky Park, 1.1 km from Mayo Clinic
8.6 out of 10, Excellent, (1,001 reviews)
"Great location"
United States
Stacy
The price is €93
includes taxes & fees
12 Jul - 13 Jul
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
2.6 km from Mayo Clinic
8.8 out of 10, Excellent, (897 reviews)
"check in was excellent"
United States
Steve
The price is €73
includes taxes & fees
2 Jul - 3 Jul
Quality Inn & Suites Mayo Clinic Area

Residence Inn by Marriott Rochester Mayo Clinic Area

Residence Inn by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester, 0.2 km from Mayo Clinic
8.6 out of 10, Excellent, (209 reviews)
"Dan, the manager was so friendly and accommodating! "
United States
Brittany
The price is €179
includes taxes & fees
28 Jun - 29 Jun
Residence Inn by Marriott Rochester Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Mayo Clinic

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Presidential Suite, Multiple Beds | Living area
Hilton Rochester Mayo Clinic Area
3.5 star property
9.6
Exceptional
608 reviews
View
Pub
TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
9.6
Exceptional
536 reviews
View
Courtyard
EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
9.4
Exceptional
1,013 reviews
View
Lobby
The Berkman
3.0 star property
9.6
Exceptional
416 reviews
View
Lobby
Staybridge Suites Rochester - Mayo Clinic Area by IHG
3.0 star property
9.4
Exceptional
486 reviews
View

Top Mayo Clinic Hotel Reviews

Frequently asked questions

What's the area like around Mayo Clinic?
Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 148 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Mayo Clinic?
Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Hyatt House Rochester/Mayo Clinic Area.
How many hotels should I expect to find near Mayo Clinic?
Expedia has 148 hotels and other accommodation options within a mile from Mayo Clinic.
If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?
Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.
What can I see and do near Mayo Clinic?
You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Explore a world of travel with Expedia