A white colonial-style building with a bell tower, surrounded by cacti and flowering plants.

Mission Valley Hotel Guide - Hotels with Spa in Mission Valley, San Diego

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mission Valley Hotels with Spa

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Our top choices for Mission Valley hotels with a spa

A resort with a large swimming pool surrounded by lounge chairs and palm trees.

1. Handlery Hotel

Handlery Hotel
3.5 star property
Mission Valley
8.4 out of 10, Very good, (3,040 reviews)
"Great location!"
United States
Helen
The price is €100
includes taxes & fees
1 Nov - 2 Nov
Handlery Hotel
A neatly made bed with a patterned throw, a small stool, a wall-mounted shelf with plants, and a painting.

2. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (3,098 reviews)
"We really enjoyed our stay. The pool was great and really enjoyed the bar and staff"
United States
Kathy
The price is €158
includes taxes & fees
22 Nov - 23 Nov
Legacy Resort Hotel & Spa
A rooftop lounge area with outdoor seating, a pool, and umbrellas.

3. Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Gaslamp Quarter, 7 km from Mission Valley
9.4 out of 10, Exceptional, (2,438 reviews)
"Very awesome pet friendly hotel and the staff were amazing"
United States
gregory
The price is €209
includes taxes & fees
22 Nov - 23 Nov
Omni San Diego Hotel at the Ballpark
A sign for the Historic Heart of San Diego, featuring ornate design and illuminated lettering.

4. The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
6.2 km from Mission Valley
8.8 out of 10, Excellent, (1,328 reviews)
"Lovely room, clean and spacious. Location was great, walkable or a short drive away from where we needed to go. Would definitely stay here again!"
United States
Andrey
The price is €192
includes taxes & fees
23 Nov - 24 Nov
The Westin San Diego Bayview
A reception area with a wooden reception desk, a potted plant, and a sofa with cushions.

5. Westgate Hotel

Westgate Hotel
4.5 star property
6.1 km from Mission Valley
9.4 out of 10, Exceptional, (1,070 reviews)
"Huge, immaculate rooms, lovely old lobby, and wonderful pool area."
United States
Rosanne
The price is €189
includes taxes & fees
8 Nov - 9 Nov
Westgate Hotel
A modern building with a sloped roof and large windows, surrounded by palm trees and a well-maintained garden.

6. Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
9.3 km from Mission Valley
9.0 out of 10, Wonderful, (1,637 reviews)
"We have stayed here many times and always have a wonderful time. Great location, in the center of everything, views are amazing and the staff is excellent!"
United States
Rebecca
The price is €129
includes taxes & fees
22 Nov - 23 Nov
Best Western Plus Island Palms Hotel & Marina
A spacious lobby with a reception desk, seating area, and a stone wall.

7. Humphreys Half Moon Inn

Humphreys Half Moon Inn
3.5 star property
8.7 km from Mission Valley
9.2 out of 10, Wonderful, (3,152 reviews)
"Nice and brand new hotel, room was really clean, Staff were really nice to us."
United States
Yan
The price is €186
includes taxes & fees
23 Nov - 24 Nov
Humphreys Half Moon Inn
A poolside view with a lounge chair, a towel, a tray with a drink and a coconut, and a pool with palm trees in the background.

8. San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 5.4 km from Mission Valley
8.6 out of 10, Excellent, (1,661 reviews)
"Beautiful property, great staff."
United States
Mary
The price is €241
includes taxes & fees
29 Nov - 30 Nov
San Diego Mission Bay Resort
A spacious lobby with a reception desk, seating area, and artwork on the walls.

9. Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay, 8.1 km from Mission Valley
8.4 out of 10, Very good, (1,647 reviews)
"Beautiful and the breakfast was delicious!"
United States
Megan
The price is €244
includes taxes & fees
29 Nov - 30 Nov
Hyatt Regency Mission Bay Spa and Marina
An aerial view of a resort with a central swimming pool, palm trees, and a view of the ocean and beach.

10. Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay, 8 km from Mission Valley
8.8 out of 10, Excellent, (2,961 reviews)
"Loved staying at Paradise Point!"
United States
victor
The price is €252
includes taxes & fees
1 Nov - 2 Nov
Paradise Point Resort & Spa
An outdoor patio area with string lights, seating arrangements, and a fire feature.

11. El Cordova Hotel on Coronado Island

El Cordova Hotel on Coronado Island
3.5 star property
10 km from Mission Valley
8.8 out of 10, Excellent, (1,007 reviews)
"Perfect location, clean place. Miguel’s restaurant right below. Great Place!"
United States
Sean
The price is €162
includes taxes & fees
22 Nov - 23 Nov
El Cordova Hotel on Coronado Island
An aerial view of a coastal resort with multiple buildings, marina, and a pier.

12. Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
15.6 km from Mission Valley
9.0 out of 10, Wonderful, (1,152 reviews)
"We really enjoyed our stay at Loews. The location was beautiful and the staff was super friendly and accommodating. Looking forward to visiting again!"
United States
Irene
The price is €237
includes taxes & fees
22 Nov - 23 Nov
Loews Coronado Bay Resort
A modern lobby with seating areas, a large plant, and a neutral color scheme.

13. Coronado Island Marriott Resort & Spa

Coronado Island Marriott Resort & Spa
4.0 star property
8.5 km from Mission Valley
8.4 out of 10, Very good, (1,000 reviews)
"Great staff, location, and room was clean and nice."
United States
Keri
The price is €314
includes taxes & fees
29 Nov - 30 Nov
Coronado Island Marriott Resort & Spa
A hotel entrance with a modern building, a central illuminated sculpture, and a landscaped area with plants.

14. The Westin San Diego Gaslamp Quarter

The Westin San Diego Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 6.3 km from Mission Valley
9.0 out of 10, Wonderful, (1,001 reviews)
"Staff was nice and helpful z"
United States
Vanessa
The price is €232
includes taxes & fees
24 Nov - 25 Nov
The Westin San Diego Gaslamp Quarter
A row of sun loungers with white cushions and striped pillows, a wooden tray with a drink and snacks, and a view of the sea in the background.

15. Pendry San Diego

Pendry San Diego
5.0 star property
Gaslamp Quarter, 6.8 km from Mission Valley
9.4 out of 10, Exceptional, (1,003 reviews)
"Very nice property in the downtown."
United States
Vasilios
The price is €355
includes taxes & fees
22 Nov - 23 Nov
Pendry San Diego
A modern living room with a stone fireplace, sofas, a coffee table, and a view of the upper floor.

16. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
13.1 km from Mission Valley
9.2 out of 10, Wonderful, (4,217 reviews)
"Great property, friendly staff and a restaurant with good food and live music next door. Had an excellent time!"
United States
Candas
The price is €132
includes taxes & fees
8 Nov - 9 Nov
Best Western Plus Marina Gateway Hotel
A spacious lobby with a marble reception desk, comfortable seating, and potted plants.

17. Pacific Terrace Hotel

Pacific Terrace Hotel
4.0 star property
North Pacific Beach, 10.2 km from Mission Valley
9.8 out of 10, Exceptional, (1,002 reviews)
"Very friendly staff, it’s a great hotel right on PB with tons of restaurants and bars on the walk!"
United States
Allen Dean
The price is €211
includes taxes & fees
16 Nov - 17 Nov
Pacific Terrace Hotel
A spacious lobby with high ceilings, a fireplace, and a variety of seating options including armchairs and sofas.

18. Kona Kai San Diego

Kona Kai San Diego
4.0 star property
9.9 km from Mission Valley
8.2 out of 10, Very good, (1,002 reviews)
"Would definitely stay here again"
United States
Michael
The price is €258
includes taxes & fees
1 Nov - 2 Nov
Kona Kai San Diego
A person sitting by a pool with a tiled floor and a marble wall.

19. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
30.2 km from Mission Valley
9.4 out of 10, Exceptional, (2,207 reviews)
"Great stay!"
United States
Kimberly
The price is €100
includes taxes & fees
3 Nov - 4 Nov
Sycuan Casino Resort
A dining area with a checkered floor, wooden chairs, a marble table, and a view of tropical foliage through large windows.

20. Catamaran Resort and Spa

Catamaran Resort and Spa
4.0 star property
Mission Beach, 9.5 km from Mission Valley
8.6 out of 10, Excellent, (1,391 reviews)
"We had a wonderful stay. Perfect location, amazing room and super friendly staff."
United States
Whitney
The price is €236
includes taxes & fees
29 Nov - 30 Nov
Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at spa hotels in Mission Valley

Pool
Breakfast included

Top Mission Valley Hotel Reviews

Best Western Seven Seas

Best Western Seven Seas

8/10 Good
"Staff was not friendly, but not rude. Coffee was way over priced and should be free to guest. Room and grounds were very clean."
PM 2-night trip
Posted less than an hour ago
Best Western Seven Seas

Frequently asked questions

Looking to holiday at a spa hotel in Mission Valley?
Treat yourself to some pampering and book a hotel with a spa. Travellers love the historical sites and shops in Mission Valley. Enjoy the museums and beaches during your holiday. Spa hotels are the perfect way to take a break from your daily routine and add a layer of luxury to your holiday.
What is the best spa hotel in Mission Valley?
Legacy Resort Hotel & Spa is a top spa hotel featuring a fitness centre, a bar, an outdoor pool and a restaurant. Spend an afternoon at the spa where you'll find facials, body scrubs and Swedish massages. Another popular spa hotel in Mission Valley is Handlery Hotel.
How many spa hotels are there in Mission Valley?
Among Expedia's 121 accommodation options in Mission Valley, there are 2 spa hotels.
What's there to see and do in Mission Valley?
Enjoy all that Mission Valley has to offer and visit Mission Valley Mall, Fashion Valley Mall and Snapdragon Stadium. If you have a little extra time during your trip, you might want to check out Town and Country San Diego and Legacy International Center.
What is a Mission Valley spa hotel?
Spa hotels in Mission Valley have on-site spas which offer services such as therapies and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on holiday.

Explore a world of travel with Expedia