Aerial view of house in Serra Mesa City in San Diego, California, USA. Green Dry Valley and Villas

San Diego Hotel Guide. Hotels in Serra Mesa, San Diego, United States of America

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Our top choices for Serra Mesa hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,984 reviews)
"Always a great stay"
United States
Jeanette
The price is €136
includes taxes & fees
16 Jun - 17 Jun
Sycuan Casino Resort

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
26 km from Serra Mesa
9.8 out of 10, Exceptional, (1,106 reviews)
"Nice place good food for breakfast 👍"
United States
Paul
The price is €188
includes taxes & fees
28 Jun - 29 Jun
Ayres Hotel San Diego South - Chula Vista

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3,892 reviews)
"Great stay"
United States
Cameron
The price is €161
includes taxes & fees
15 Jun - 16 Jun
Best Western Plus Marina Gateway Hotel

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,735 reviews)
"Good location, clean room and nice staff. A great place to stay."
United States
Patricia
The price is €170
includes taxes & fees
29 Jun - 30 Jun
Hampton Inn & Suites San Diego Airport Liberty Station

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
18.6 km from Serra Mesa
8.2 out of 10, Very good, (1,556 reviews)
"Everything was excellent. Room, breakfast location and staff. This was our second time staying here and we'll be back."
United States
Chris
The price is €128
includes taxes & fees
28 Jun - 29 Jun
Comfort Inn Chula Vista San Diego South

Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
16.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,006 reviews)
"Staff was friendly. Place was very clean and spacious"
United States
Lucy
The price is €180
includes taxes & fees
28 Jun - 29 Jun
Courtyard by Marriott San Diego El Cajon

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,278 reviews)
"Clean room, staff was very helpful, parking was easy and accessible!"
United States
Hector
The price is €118
includes taxes & fees
15 Jun - 16 Jun
Wyndham Garden San Diego Near SeaWorld

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.4 out of 10, Exceptional, (1,240 reviews)
"The best hotel we stayed so far!"
United States
Arvydas
The price is €156
includes taxes & fees
28 Jun - 29 Jun
Holiday Inn Express San Diego South - Chula Vista by IHG

Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA
3.0 star property
11.7 km from Serra Mesa
9.0 out of 10, Wonderful, (1,524 reviews)
"Very great stay"
United States
Phillip
The price is €184
includes taxes & fees
21 Jun - 22 Jun
Country Inn & Suites by Radisson, San Diego North, CA

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
6 km from Serra Mesa
8.8 out of 10, Excellent, (3,740 reviews)
"Clean room, friendly staff, and my kid loved the pool!"
United States
Mark
The price is €96
includes taxes & fees
16 Jun - 17 Jun
Kings Inn San Diego

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
8.8 out of 10, Excellent, (1,308 reviews)
"The breakfast was great, the staff was helpful, and the room was clean and spacious!"
United States
Christopher
The price is €120
includes taxes & fees
28 Jun - 29 Jun
Best Western Americana Inn

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (2,165 reviews)
"THE BED WAS SO SOFT ROOM WAS SO CLEAN BREAKFAST WAS GREAT AND THE PRICE WAS KILLER FOR THE LOCATION really a great place to stay"
United States
Tyson
The price is €142
includes taxes & fees
15 Jun - 16 Jun
GreenTree Inn San Diego Mission Bay

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego, 7.6 km from Serra Mesa
8.4 out of 10, Very good, (2,064 reviews)
"Excellent stay! Beautiful grounds and friendly staff."
United States
Rebecca
The price is €150
includes taxes & fees
16 Jun - 17 Jun
Best Western Plus Hacienda Hotel Old Town

The Encinitan Hotel & Suites

The Encinitan Hotel & Suites
3.0 star property
30.8 km from Serra Mesa
8.2 out of 10, Very good, (1,582 reviews)
"Great place to stay"
United States
joshua
The price is €147
includes taxes & fees
15 Jun - 16 Jun
The Encinitan Hotel & Suites

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
18.7 km from Serra Mesa
8.6 out of 10, Excellent, (1,642 reviews)
"Great place to stay at, would definitely stay there again."
United States
Jose
The price is €109
includes taxes & fees
5 Jul - 6 Jul
La Quinta Inn by Wyndham San Diego Chula Vista

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
6.6 km from Serra Mesa
8.0 out of 10, Very good, (212 reviews)
"Staff was great and rooms were nice."
United States
Brittney
The price is €105
includes taxes & fees
15 Jun - 16 Jun
The Alcala Hotel Mission Valley/Seaworld

Pleasant Inn

Pleasant Inn
2.5 star property
4.8 km from Serra Mesa
8.6 out of 10, Excellent, (1,448 reviews)
"Pleasant Inn was clean and the service was great!"
United States
Shirley
The price is €100
includes taxes & fees
6 Jul - 7 Jul
Pleasant Inn

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,089 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is €170
includes taxes & fees
17 Jun - 18 Jun
Holiday Inn Express San Diego Airport - Old Town by IHG

Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar
2.0 star property
18.2 km from Serra Mesa
7.2 out of 10, Good, (1,031 reviews)
"Nice place to stay."
United States
Jacquie
The price is €119
includes taxes & fees
5 Jul - 6 Jul
Ramada by Wyndham San Diego Poway Miramar

The Rambler Hotel

The Rambler Hotel
3.0 star property
18.7 km from Serra Mesa
9.0 out of 10, Wonderful, (2,170 reviews)
"Cool vibe in an easy spot to get on and off the highway."
United States
Jami
The price is €149
includes taxes & fees
28 Jun - 29 Jun
The Rambler Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Sharp Learning Resource Center and Convoy District are also worth a stop.

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