Serra Mesa
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's entertainment choices and fascinating museums.
SeaWorld
Beautiful sea creatures, exhilarating rides and fun and educational displays – this marine park is a treat for all the family.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Mission Beach
Enjoy the old-world charm of this seaside suburb where the beautiful people live, close to central San Diego.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Things to do
City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise
San Diego: Museum of Illusions Entry Ticket
San Diego: Luggage Storage in Marina
San Diego Whale Watching Cruise
City Cruises San Diego: Best of the Bay Harbor Tour
Top hotels in Serra Mesa
Paradise Point Resort & Spa
Great family place to stay.
Reviewed on 25 Feb 2026
Bay Club Hotel & Marina
Staff was very friendly and warm. Room was very nice.
Reviewed on 26 Feb 2026
Hard Rock Hotel San Diego
Room was clean but the view, the view was amazing. I so appreciate the concierge accommodating my request to be moved up to the 10th floor. It was an absolute game changer.
Reviewed on 26 Feb 2026
The DEXTRO Little Italy, BW Premier Collection
Clean room super super comfortable bed! I mean best ever! comfy! location was great! staff was cool!
Reviewed on 25 Feb 2026
Days Inn by Wyndham San Diego Hotel Circle
Clean and very nice.
Reviewed on 26 Feb 2026
Best Western Seven Seas
Overall okay, parking was terrible
Reviewed on 26 Feb 2026
Other neighbourhoods around Serra Mesa
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Old Town San Diego
The abundant dining options and seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
