Serra Mesa
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's acclaimed art galleries and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
SeaWorld
Beautiful sea creatures, exhilarating rides and fun and educational displays – this marine park is a treat for all the family.
Balboa Park
This huge city-centre park is home to a range of fantastic cultural institutions, and it’s also a lovely place for a walk.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
San Diego Whale Watching Cruise
City Cruises San Diego: Premier Dinner Cruise
GPS Talking Tour Cars: Downtown & Gaslamp Loop
From Tijuana: Valle de Guadalupe Private Winery Tour
Top hotels in Serra Mesa
Hotel del Coronado, Curio Collection by Hilton
Balcony room in the Victorian was lovely, a good size and plenty of storage for clothes etc. Loved the shops on the lower T level and the restaurants were amazing. Valet parking is expensive but so slick and made traveling out so easy. Will definitely stay at The Del when I go back to San Diego
Reviewed on 17 Nov 2025
Legacy Resort Hotel & Spa
Nice property. The room was clean. The staff was professional. I would definitely stay there again.
Reviewed on 20 Nov 2025
Hilton San Diego Mission Valley
All clean, easy check in. Restaurant had good food.
Reviewed on 20 Nov 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
Would recommend
Reviewed on 21 Nov 2025
Bay Club Hotel & Marina
The balcony had a very nice view. The staff were nice and efficient. The onsite restaurant was convenient and there was a waitress there named Miriam I think who was wonderful!
Reviewed on 20 Nov 2025
Hard Rock Hotel San Diego
Staff was great Our suite was extremely nice the sound system was great. Gaslamp area was great lots of great food.
Reviewed on 17 Nov 2025
Other neighbourhoods around Serra Mesa
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
Old Town San Diego
The abundant dining options and seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.
