Downtown South San Francisco

San Francisco

Aerial View of a Local High School and an Athletic Field in a Neighborhood in South San Francisco, California, USA
Aerial View of a Local High School and an Athletic Field in a Neighborhood in South San Francisco, California, USA
Aerial view of the South San Francisco area
Authentic Caldo de Res!

Popular places to visit

Things to do


Top hotels in Downtown South San Francisco

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is €119 per night from 25 Jan to 26 Jan
€119
25 Jan - 26 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
8.8/10 Excellent! (5,151 reviews)
Clean room, pleasant staff!

Reviewed on 19 Jan 2026

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is €153 per night from 25 Jan to 26 Jan
€153
25 Jan - 26 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
8.8/10 Excellent! (7,290 reviews)
Yes room was big nice and clean staff very friendly breakfast very good we will stay again close to everything

Reviewed on 22 Jan 2026

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is €106 per night from 1 Feb to 2 Feb
€106
1 Feb - 2 Feb
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (2,314 reviews)
Great location, room met expectations.

Reviewed on 21 Jan 2026

Hilton San Francisco Financial District
Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown

3 out of 5
701 3rd St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is €160 per night from 20 Feb to 21 Feb
€160
20 Feb - 21 Feb
includes taxes & fees
Stay at this hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and parking (surcharge). Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (1,954 reviews)
Very clean, nice staff, beautiful hotel and comfortable accomodations. We'll stay here again. 1 block from giants

Reviewed on 19 Jan 2026

Hyatt Place San Francisco Downtown
Comfort Inn by the Bay

Comfort Inn by the Bay

2.5 out of 5
2775 Van Ness Ave San Francisco CA
The price is €102 per night from 29 Jan to 30 Jan
€102
29 Jan - 30 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and parking (surcharge). Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,273 reviews)
Clean, comfortable beds, good breakfast, friendly staff, good location.

Reviewed on 19 Jan 2026

Comfort Inn by the Bay
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
The price is €107 per night from 16 Feb to 17 Feb
€107
16 Feb - 17 Feb
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (2,905 reviews)
Kitchen has no cookware. Nice room tho

Reviewed on 20 Jan 2026

Club Quarters Hotel in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Downtown South San Francisco

San Francisco city aerial The Embarcadero bayside view with docs and downtown skyscrapers, CA

Excelsior

Though Excelsior may not have many top sights, you can venture to the surrounding area to see attractions like Cow Palace and San Bruno Mountain State Park.

Excelsior
Aerial View Of Urban Neighborhood

Noe Valley

Appreciated for its churches and architecture, you might consider exploring Noe Valley. Check out the variety of things to see and do like 22nd St Hill, and jump on the metro at Church St & Clipper St Stop or Church St & 24th St Stop to get around the city.

Noe Valley
Mission District which includes outdoor art

Mission District

3.5/5(11 area reviews)

You might enjoy the bars while in Mission District. SF Armory is a notable sight, and you can get around town at 16th Street Mission Station or 24th Street Mission Station to see more of the city.

Mission District
Anchor Brewing Company featuring a city

Potrero Hill

The live music and architecture are just a few things visitors like about Potrero Hill. San Francisco Bay and Museum of Craft & Design are worthwhile spots to check out, and you can hop on the metro at 20th Street Station or 23rd Street Station to get around the larger area.

Potrero Hill
Sunset District which includes a bridge and a river or creek

Sunset District

3.5/5(6 area reviews)

Consider exploring the beaches in Sunset District. If sightseeing is on the list, Ocean Beach is a top attraction. Hop on the metro at Judah Street & Sunset Boulevard Station or Judah St & 34th Ave Stop to see more of the area.

Sunset District
Last light

Mission Bay

While you're in Mission Bay, take in top sights like Chase Center or Lefty O'Doul Bridge, and hop on the metro to see more of the city at UCSF/Chase Center Stop or Mission Rock Station.

Mission Bay


Downtown South San Francisco

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