Santo Spirito Holidays

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    Save up to €185 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
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Historic Centre of Florence

9 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Top hotels in Santo Spirito

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
The price is €126 per night from 21 Dec to 22 Dec
€126
21 Dec - 22 Dec
includes taxes & fees
9.6/10 Exceptional! (594 reviews)
Staff were super lovely, we were greeted by a very enthusiastic and full of character Giovanni who made us feel welcome. The place is very well kept, breakfast had a surprisingly wider variety of food for a continental breakfast, and is in a nice quiet part of Florence that is still accessible to ...

Reviewed on 22 Nov 2025

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
Fully refundableReserve now, pay when you stay
9.2/10 Wonderful! (1,053 reviews)
Perfect stay

Reviewed on 18 Nov 2025

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Palazzo Mannaioni Suites
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
The price is €87 per night from 1 Dec to 2 Dec
€87
1 Dec - 2 Dec
includes taxes & fees
9/10 Wonderful! (223 reviews)
We are seniors and walked to city centre every day. Great restaurants nearby. We loved Florence

Reviewed on 22 Nov 2025

La Torre Del Cestello
See all 476 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santo Spirito holiday package cost?
From just . Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favourite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito holiday package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1,000,000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Centre Of Florence.
How far in advance should I book my Santo Spirito holiday?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including holiday rentals like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia holiday package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our holiday packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito holiday package?
If your holiday plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

Things to do

Close up of sculptures in front of Pisa.

Excursion to Pisa - Escorted Round Trip by bus

€39
per adult
72% of travellers recommend
Excursion to Pisa - Escorted Round Trip by bus
Pisa, Siena and San Gimignano day trip from Florence

Pisa, Siena and San Gimignano day trip from Florence

€65
per adult
86% of travellers recommend
Pisa, Siena and San Gimignano day trip from Florence
Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

€24
per adult
78% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.