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Sikeston Hotel Guide - LGBT-Friendly Hotels in Sikeston, Missouri
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Our top choices for Sikeston LGBT-friendly hotels
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
Brian
The price is €87
includes taxes & fees
11 Jan - 12 Jan 2026
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
Laura
The price is €75
includes taxes & fees
1 Jan - 2 Jan 2026
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1001)
"This Drury is our preferred place to stay when visiting family in Cape Girardeau. The hotel Staff is always warm and small town friendly! The hotel is nice and the breakfast buffet is outstanding!! "
Michael
The price is €86
includes taxes & fees
4 Jan - 5 Jan 2026
9.4 out of 10, Exceptional, (1000)
"Great place. Friendly staff clean"
Jeff
The price is €88
includes taxes & fees
4 Jan - 5 Jan 2026
9.0 out of 10, Wonderful, (1001)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
Colleen
The price is €67
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (445)
"Stay was excellent "
Kourtney
The price is €89
includes taxes & fees
25 Jan - 26 Jan 2026
9.4 out of 10, Exceptional, (1001)
"Very clean, very friendly! We will be staying again. "
Beth
The price is €73
includes taxes & fees
22 Jan - 23 Jan 2026
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical CenterCape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
Arthur
The price is €67
includes taxes & fees
4 Jan - 5 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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