Sikeston Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €900 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is €112 per night from 16 Jul to 17 Jul
€112
16 Jul - 17 Jul
includes taxes & fees
9.6/10 Exceptional! (1,012 reviews)
"My wife and I are traveling and found your hotel to be one of the best where we stay. The staff was extremely friendly, helpful, courteous, and kind. They represented the company well stay there again."

Reviewed on 9 Jul 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
The price is €68 per night from 3 Aug to 4 Aug
€68
3 Aug - 4 Aug
includes taxes & fees
7.2/10 Good! (1,004 reviews)
"I had a stay at this hotel. The rooms were clean, comfortable, and well maintained. The staff was friendly, professional, and always willing to help. The location was in a convenient place for us to take a quick rest The breakfast was delicious with plenty of options, and the overall atmosphere was ..."

Reviewed on 4 Jul 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is €85 per night from 26 Jul to 27 Jul
€85
26 Jul - 27 Jul
includes taxes & fees
8.4/10 Very good! (1,005 reviews)
"Stay was okay for a night."

Reviewed on 10 Jul 2026

Best Western Plus Sikeston I-55
See all 319 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
See properties

Frequently asked questions

How much does a Sikeston holiday package cost?
You'll find cheap prices on Expedia for your Sikeston getaway. However, a range of factors like the season, length of stay and your choice of hotel will determine how much your holiday to Sikeston costs.
What are the cheapest months to go to Sikeston?
January, February and September are the best times to look for cheap Sikeston holiday packages. Opting to travel in quieter periods means you'll typically find better prices on hotels and flights.
How many days is enough for Sikeston?
You can easily see all the top attractions in Sikeston in a few days, including the popular Sikeston Depot Museum. If you want an extended Sikeston holiday, check out which kind of excursions and activities are available nearby.
Is it worth booking a holiday package to Sikeston?
Sikeston has everything you need for an unforgettable trip. Begin your Sikeston holiday on a high note by exploring top attractions like Central Park.
How to find the best Sikeston package deals?
Use Expedia's filters to find some great Sikeston package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or look for Sikeston package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your holiday package as soon as possible.
Is it cheaper to book a Sikeston holiday as a package?
An Expedia holiday package could land you significant savings when compared to booking stays and flights separately. Better still, you can tailor your Sikeston escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a holiday package to Sikeston?
Enjoy incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for a spur-of-the-moment Sikeston trip.
How to plan a trip to Sikeston?

  1. Choose the right time to travel: Your schedule, favourite season and the type of weather you like can all impact your decision on when to visit Sikeston.
  2. Set your budget: Factor in expenses like flights, transportation and food when working out how much to save for your trip to Sikeston. Then, pick a hotel that suits your budget, whether that's an economical stay or a lavish retreat.
  3. Determine how many days away: Start by compiling a list of the attractions and activities you want to experience in Sikeston. Then, estimate how long you'll need at each, along with any travel time.
  4. Bundle your bookings: With your travel dates in order, you can combine your flights, hotels, car rental and more into a personalised Sikeston holiday package.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.