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Southeast Missouri Hotels
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Our top choices for Southeast Missouri hotels
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
7.8 out of 10, Good, (1,005 reviews)
"It was a nice stay."
Rebecca
The price is €53
includes taxes & fees
13 Jan - 14 Jan
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,002 reviews)
"Breakfast was excellent, and fresh. Room was clean and spacious. We enjoyed our brief stay."
Nicole
The price is €89
includes taxes & fees
18 Jan - 19 Jan
The Farmstead Hotel
The Farmstead HotelCaruthersville
8.8 out of 10, Excellent, (470 reviews)
"Clean room, very nice staff"
Mack
The price is €79
includes taxes & fees
13 Jan - 14 Jan
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (685 reviews)
"Conveniently located, clean, friendly staff."
Philip
The price is €78
includes taxes & fees
19 Jan - 20 Jan
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,007 reviews)
"Great place "
Kelly
The price is €87
includes taxes & fees
20 Jan - 21 Jan
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very good, (728 reviews)
"Clean room and easy access to room"
Anne
The price is €54
includes taxes & fees
13 Jan - 14 Jan
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (864 reviews)
"The size of the room. The staff were great. The room was very clean. Will definitely stay there again."
Brenda
The price is €101
includes taxes & fees
31 Jan - 1 Feb
Best Western Plus Sikeston
Best Western Plus SikestonSikeston
8.4 out of 10, Very good, (1,008 reviews)
"Great stay, everything was clean and comfortable. "
Charles
The price is €66
includes taxes & fees
18 Jan - 19 Jan
Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (219 reviews)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
Joanne
The price is €149
includes taxes & fees
13 Jan - 14 Jan
Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
8.8 out of 10, Excellent, (711 reviews)
"Amazing place"
Mladen
The price is €113
includes taxes & fees
6 Feb - 7 Feb
Shepherd Mountain Inn
Shepherd Mountain InnIronton
9.4 out of 10, Exceptional, (304 reviews)
"Everything was wonderful- the family that owns this is very kind, and it’s in a beautiful location!"
Nathan
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,003 reviews)
"Breakfast was great- staff was welcoming. Will stay there again."
Laura
The price is €75
includes taxes & fees
13 Jan - 14 Jan
Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (977 reviews)
"Great location and room "
Curtis
The price is €99
includes taxes & fees
15 Jan - 16 Jan
Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (336 reviews)
"Staff was very friendly."
Joyce
The price is €84
includes taxes & fees
18 Jan - 19 Jan
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (445 reviews)
"Stay was excellent "
Kourtney
The price is €102
includes taxes & fees
18 Jan - 19 Jan
Fort Davidson Hotel
Fort Davidson HotelIronton
9.2 out of 10, Wonderful, (175 reviews)
"Absolutely Love It!!! Clean, Quiet, and all around a safe place to stay..."
Kyle
The price is €113
includes taxes & fees
13 Jan - 14 Jan
Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (462 reviews)
"Very clean and super friendly staff!"
Katherine
The price is €97
includes taxes & fees
8 Feb - 9 Feb
Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (578 reviews)
"Clean, friendly staff enjoyed the stay"
John
The price is €126
includes taxes & fees
13 Jan - 14 Jan
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very good, (1,004 reviews)
"Great stay"
Kelsea Arloetta
The price is €52
includes taxes & fees
18 Jan - 19 Jan
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
9.0 out of 10, Wonderful, (1,001 reviews)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
Colleen
The price is €68
includes taxes & fees
20 Jan - 21 Jan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Showing deals for:23 Jan - 25 Jan
Image gallery for Johnson's Shut-ins State Park
Johnson's Shut-ins State Park
Middle Brook
10/10Exceptional (1 review)
Member Price available
Price is €483
for 2 nights, 1 cabin
€242 per night
includes taxes & fees
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Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is €52 per night from 18 Jan to 19 Jan
€52
18 Jan - 19 Jan
includes taxes & fees
7.8/10 Good! (1,004 reviews)
4 Star Hotels
2 properties
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