Southeast Missouri Hotels from €56 - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

Breakfast included

Cabin

Hot tub

Hotel

Pet-friendly

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

1. Shepherd Mountain Inn

Ironton

Katie

€115

includes taxes & fees

28 Aug - 29 Aug

A cabin with a large window, surrounded by trees.

A cabin with a cozy interior, a dining area, and a visible window.

2. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

Ronrecus

€129

includes taxes & fees

31 Aug - 1 Sept

A living room with a blue wall, a fireplace, a sofa, and a chair.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A brick building with a sign reading "Mercantile & Hotel".

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

3. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

€94

includes taxes & fees

23 Sept - 24 Sept

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

4. Fort Davidson Hotel

Ironton

richard

€117

includes taxes & fees

6 Sept - 7 Sept

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

A hotel room with two beds, a brick wall, and a wooden headboard.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

5. Drury Inn & Suites Jackson MO

Jackson

Jamie

€79

includes taxes & fees

17 Sept - 18 Sept

A motel with a covered entrance, a flag, and a phone number.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

6. Madison Inn Lodge

Fredericktown

Melissa

€82

includes taxes & fees

14 Sept - 15 Sept

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A Holiday Inn Express & Suites building with a covered entrance and multiple windows.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and a ceiling with recessed lighting.

A modern dining area with high tables and chairs, a television screen, and a view of the outdoors through large windows.

7. Holiday Inn Express & Suites Perryville by IHG

Perryville

Kristen

€95

includes taxes & fees

3 Sept - 4 Sept

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A gym with cardio equipment, a bench press, and a squat rack.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

8. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

ILUNGA

€56

includes taxes & fees

6 Sept - 7 Sept

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

9. Hampton Inn Poplar Bluff

Poplar Bluff

Philip

€90

includes taxes & fees

13 Sept - 14 Sept

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A corner market with a refrigerated display case and a pantry area.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

10. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Arsenia

€98

includes taxes & fees

7 Sept - 8 Sept

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

11. The Riverview

Cape Girardeau

Alyssa

€110

includes taxes & fees

31 Aug - 1 Sept

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

12. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Heather

€98

includes taxes & fees

17 Sept - 18 Sept

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A swimming pool with a small water slide, surrounded by lounge chairs and umbrellas.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

A playground with a wooden playhouse, a slide, and two animal-shaped swings.

13. Perryville RV Resort

Perryville

Von

€65

includes taxes & fees

30 Aug - 31 Aug

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

14. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Matthew

€97

includes taxes & fees

6 Sept - 7 Sept

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

15. Drury Inn & Suites Sikeston, MO

Sikeston

Sally

€93

includes taxes & fees

14 Sept - 15 Sept

A modern retail area with a display of local items and snacks.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

16. Tru By Hilton Cape Girardeau

Cape Girardeau

Darlene

€87

includes taxes & fees

3 Sept - 4 Sept

A Holiday Inn Express & Suites building with a covered entrance, brick facade, and multiple windows.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

A lobby with a reception desk, two armchairs, a lamp, and a wall with wood grain artwork.

A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

17. Holiday Inn Express & Suites Farmington by IHG

Farmington

Shawn

€103

includes taxes & fees

30 Aug - 31 Aug

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

18. Super 8 by Wyndham Farmington

Farmington

Saundra

€56

includes taxes & fees

2 Sept - 3 Sept

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

19. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Bonnie

€70

includes taxes & fees

31 Aug - 1 Sept

A narrow corridor with a bar area on the right, featuring a counter and hanging lights.

A room with a wooden floor, a bed, a desk with a coffee maker, a mirror, and a sliding door leading to a bathroom.

A large boulder in a natural setting with autumn-colored trees in the background.

A large rock formation with a clear sky and autumn foliage in the background.

20. Black River Motel and Restaurant

Lesterville

Douglas

€105

includes taxes & fees

30 Aug - 31 Aug

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Holiday Rentals in Southeast Missouri

Cabin

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.

A view through a window with a stone wall and a wooden structure in the background.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

A bedroom with a wooden bed, a bench, and a window.

A wooden deck with a railing leading to a building with a metal roof and a brown door.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"I really enjoyed my time at the stay !"

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a sign that reads "The Atrium Boutique Hotel".

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A hallway with exposed brick walls, wooden flooring, and a white door.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

A cozy living room with wooden ceilings, a ceiling fan, two sofas, a coffee table, a rug, and a bookshelf with books and games.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A red house with a wooden deck and stone steps leading to a porch.

A red house with a wooden deck, large sliding glass doors, and a chimney.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Our one-night stay was very pleasant. The room was comfortable and clean, and it was suitable for my husband, our cat, and me. The staff was friendly and professional. The location was convenient, close to restaurants and the highway. We look forward to staying here again."

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Competitively priced. Complimentary happy hour and hot breakfast were exceptional. We stay at a Drury Inn whenever they are available."

Honeysuckle Inn - Mountain View

8/10 Good

"There was lots of parking.The breakfast was basic, but appreciated.The staff was the best !! They helped us find places and were very nice 🙂"

Comfort Inn Festus - St Louis South

8/10 Good

"Staff was very friendly and helpful. Room could have been a little cleaner. Standard free breakfast. Room needed some repairs."

Baymont Inn and Suites by Wyndham Farmington, MO

8/10 Good

"It was a nice stay"

The Riverview

8/10 Good

"Nice view of the river. The staff was nice."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Great value, very clean and breakfast was actually good."

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"We stay here every time we are in Sikesons. Can't beat this hotel. Super clean 'comfortable!' beds, living room area, and bathrooms. Small hot breakfast. All for the best price out there. Don't skip on this hotel! Staff is always polite and helpful. We always love to walk out to the pond"

Motel 6 Poplar Bluff, MO

8/10 Good

"Clean and nice."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

€56

6 Sept - 7 Sept

includes taxes & fees

8/10 Very good! (1,001 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

€61

20 Sept - 21 Sept

includes taxes & fees

7.8/10 Good! (993 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

€64

30 Aug - 31 Aug

includes taxes & fees

7.2/10 Good! (1,000 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

€76

28 Aug - 29 Aug

includes taxes & fees

8/10 Very good! (1,000 reviews)

The Farmstead Hotel

778 E 3rd St Caruthersville MO

€79

28 Aug - 29 Aug

includes taxes & fees

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

€96

27 Sept - 28 Sept

includes taxes & fees

Southeast Missouri Hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

3. EC Reed's Mercantile and Hotel

4. Fort Davidson Hotel

5. Drury Inn & Suites Jackson MO

6. Madison Inn Lodge

7. Holiday Inn Express & Suites Perryville by IHG

8. Baymont Inn and Suites by Wyndham Farmington, MO

9. Hampton Inn Poplar Bluff

10. Fairfield Inn & Suites by Marriott Poplar Bluff

11. The Riverview

12. Fairfield Inn & Suites by Marriott Cape Girardeau

13. Perryville RV Resort

14. Drury Plaza Hotel Cape Girardeau Conference Center

15. Drury Inn & Suites Sikeston, MO

16. Tru By Hilton Cape Girardeau

17. Holiday Inn Express & Suites Farmington by IHG

18. Super 8 by Wyndham Farmington

19. Pear Tree Inn Cape Girardeau West

20. Black River Motel and Restaurant

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Lake Wappapello

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Tiny Houses of French Village

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

The Atrium - A Boutique Hotel

Urban Lofts

Cozy Belgrade Cottage w/ Wood-burning Stove!

Walk to Current River: Ozarks Adventure Home!

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

Drury Plaza Hotel Cape Girardeau Conference Center

Honeysuckle Inn - Mountain View

Comfort Inn Festus - St Louis South

Baymont Inn and Suites by Wyndham Farmington, MO

The Riverview

Drury Inn & Suites Sikeston, MO

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Comfort Inn Festus - St Louis South

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

The Farmstead Hotel

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

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