Southeast Missouri Hotels from €56 - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

1. Hampton Inn & Suites By Hilton Festus

Festus

Abram

€91

includes taxes & fees

29 Oct - 30 Oct

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

2. Super 8 by Wyndham Farmington

Farmington

Marisa

€61

includes taxes & fees

23 Oct - 24 Oct

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A building with a red awning labeled "Shepherd Mountain Inn."

A hotel room with two beds, a lamp, and a painting on the wall.

3. Shepherd Mountain Inn

Ironton

Michael

€120

includes taxes & fees

12 Oct - 13 Oct

A motel with a covered entrance, a flag, and a phone number.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

4. Madison Inn Lodge

Fredericktown

Bawan

€79

includes taxes & fees

3 Nov - 4 Nov

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

A hotel room with two beds, a brick wall, and a wooden headboard.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

5. Drury Inn & Suites Jackson MO

Jackson

Debra S

€76

includes taxes & fees

15 Oct - 16 Oct

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A gym with cardio equipment, a bench press, and a squat rack.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

6. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

stewart

€56

includes taxes & fees

1 Nov - 2 Nov

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

7. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

€112

includes taxes & fees

18 Oct - 19 Oct

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

8. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

€91

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A hotel room with two beds, a desk, a chair, and a view of the city.

9. The Riverview

Cape Girardeau

Alyssa

€115

includes taxes & fees

13 Oct - 14 Oct

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

An outdoor pool area with lounge chairs and an umbrella.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

10. Fort Davidson Hotel

Ironton

richard

€117

includes taxes & fees

10 Nov - 11 Nov

A living room with a blue wall, a fireplace, a sofa, and a chair.

A bar area with stools and a counter where a bartender is serving drinks.

A brick building with a sign reading "Mercantile & Hotel".

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

11. EC Reed's Mercantile and Hotel

Marble Hill

Miranda

€102

includes taxes & fees

12 Oct - 13 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

12. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

€103

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, a sofa, a desk, and a chair.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.

A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

13. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

€120

includes taxes & fees

1 Nov - 2 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

A corner market with a refrigerated display case and a pantry area.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

14. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Nancy

€98

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a reception desk, seating area, and large windows.

An indoor swimming pool with a clear view of the outside through large windows.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

15. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

€95

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

16. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Troy

€73

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

17. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Curtis

€101

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.

A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.

A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".

18. Hampton Inn Farmington

Farmington

Charlie

€101

includes taxes & fees

25 Oct - 26 Oct

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

19. Super 8 By Wyndham Marston

Marston

Brenda

€57

includes taxes & fees

21 Oct - 22 Oct

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A rustic cabin with a wooden exterior, a small deck, and a picnic table.

20. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

cynthia

€143

includes taxes & fees

9 Nov - 10 Nov

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Holiday Rentals in Southeast Missouri

Cabin

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

A view through a window with a stone wall and a wooden structure in the background.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A building with a sign that reads "The Atrium Boutique Hotel".

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A hallway with exposed brick walls, wooden flooring, and a white door.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cabin

A wooden deck with a railing leading to a building with a metal roof and a brown door.

A calm lake with a wooden dock and a forested island in the distance.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A spacious living area with a kitchen island, dining table, and a television.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

A single-story house with a front porch, a stone foundation, and a well-maintained lawn.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A red house with a wooden deck and stone steps leading to a porch.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A wooden deck with a hot tub, a small table, and a bench.

A rustic wooden interior with a dining table, chairs, a sofa, and a cowhide rug.

A rustic interior with a stone fireplace, wooden furniture, and a cozy seating area.

A bedroom with a sloped ceiling, a bed with a white and yellow bedspread, a wooden chair, a round rug, and a wooden wall with a window.

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville

"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Perfect place and price for a good night sleep. Toilet was extra noisy when flushed, but it worked !!"

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Nice clean large room, basic breakfest, plenty of parking"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Wonderful stay!"

Hampton Inn Sikeston

10/10 Excellent

"The front desk staff were very kind and helpful. Everything was clean and there was a good breakfast!"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Room was clean and staff was very friendly"

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"The room was clean and the staff was very helpful. A great getaway for anyone who likes nature"

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."

Silo Farm Haus- located in the heart of wine country!

10/10 Excellent

"This place is absolutely gorgeous! We really enjoyed our stay. The silo farm haus was serene, clean and comfortable. Thank you for a wonderful stay!"

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

€56

1 Nov - 2 Nov

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

€67

1 Nov - 2 Nov

includes taxes & fees

7.2/10 Good! (1,001 reviews)

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

€71

24 Oct - 25 Oct

includes taxes & fees

8/10 Very good! (1,001 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

€73

25 Oct - 26 Oct

includes taxes & fees

9.2/10 Wonderful! (1,001 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

€74

1 Nov - 2 Nov

includes taxes & fees

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

€91

18 Oct - 19 Oct

includes taxes & fees

Southeast Missouri Hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Hampton Inn & Suites By Hilton Festus

2. Super 8 by Wyndham Farmington

3. Shepherd Mountain Inn

4. Madison Inn Lodge

5. Drury Inn & Suites Jackson MO

6. Baymont Inn and Suites by Wyndham Farmington, MO

7. Crown Pointe Lodge, BW Signature Collection

8. Hampton Inn Poplar Bluff

9. The Riverview

10. Fort Davidson Hotel

11. EC Reed's Mercantile and Hotel

12. Fairfield Inn & Suites by Marriott Sikeston

13. Holiday Inn Express & Suites Farmington by IHG

14. Fairfield Inn & Suites by Marriott Poplar Bluff

15. Drury Inn & Suites Poplar Bluff

16. Pear Tree Inn Cape Girardeau West

17. Drury Plaza Hotel Cape Girardeau Conference Center

18. Hampton Inn Farmington

19. Super 8 By Wyndham Marston

20. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

The Atrium - A Boutique Hotel

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Tiny Houses of French Village

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Urban Lofts

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Hot Tub & Creek Views: Secluded Perryville Cabin

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Cape Girardeau

Hampton Inn Sikeston

Pear Tree Inn Cape Girardeau West

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Days Inn and Suites by Wyndham Sikeston

Silo Farm Haus- located in the heart of wine country!

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Hampton Inn Poplar Bluff

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