Southeast Missouri

Travel Guide

A group of men in red uniforms with gold accents, holding rifles and wearing kilts.
A river flowing through a rocky landscape with dense green forest in the background.
A rocky river with clear water flowing over rocks.
A rocky shoreline with a calm lake and distant islands.
A river running through a forested landscape with a dirt road parallel to the river.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
The price is €97 per night from 13 Sept to 14 Sept
€97
13 Sept - 14 Sept
includes taxes & fees
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,002 reviews)
"Evening sit back with cocktails is amazing and so is the breakfast."

Reviewed on 3 Sept 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
The price is €72 per night from 27 Sept to 28 Sept
€72
27 Sept - 28 Sept
includes taxes & fees
Stay at this business-friendly hotel in Festus. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ...
7.8/10 Good! (999 reviews)
"room was clean and the front staff was nice. place served it's purpose (stayed for only 2 nights). Not much amenitites."

Reviewed on 3 Sept 2026

Comfort Inn Festus - St Louis South
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
The price is €53 per night from 13 Sept to 14 Sept
€53
13 Sept - 14 Sept
includes taxes & fees
Stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking and an outdoor pool. Our guests praise the helpful staff and the clean ...
Baymont Inn and Suites by Wyndham Farmington, MO
See all 690 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios and climate control.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Lake Wappapello

Lake Wappapello

2 out of 5
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
Lake Wappapello
Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve MO
Stay at this holiday home in Ste Genevieve. Enjoy laundry facilities. Popular attractions Crown Valley Winery and Hawn State Park are located nearby.
10/10 Exceptional! (154 reviews)
"Our stay at the Silo House was absolutely wonderful! The home and surrounding property are stunning, and the peaceful setting made it the perfect escape from the hustle and bustle of everyday life. If you’re looking for a place to truly relax and recharge, this is it.My favorite part of the entire ..."

Reviewed on 5 Jul 2026

Silo Farm Haus- located in the heart of wine country!
See all properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
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Things to do

Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

€17
per adult
96% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Castle Entrance

History Tour of Pythian Castle in Springfield Missouri

€11
per adult
90% of travellers recommend
History Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Tour The Ozarks Private Springfield Brewery Tour

€185
per adult
Tour The Ozarks Private Springfield Brewery Tour
See all activities in Southeast Missouri
A clear stream with large rocks and pebbles.

Fredericktown

A calm river surrounded by autumn foliage and trees.

Bonne Terre

A rustic wooden structure with a metal roof, a wooden fence, and a building with a red roof in a grassy area.

Doniphan

A park with a gazebo, a picnic area, and a signboard.

Park Hills

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