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Holiday Rentals in Southeast Missouri

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Check prices for these dates

In two weeks
23 Oct - 25 Oct
In two months
4 Dec - 6 Dec
In three months
1 Jan - 3 Jan
In four months
29 Jan - 31 Jan

Our top choices for Southeast Missouri holiday rentals

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

1. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (113 reviews)
"The stay here gets better every time."
United States
cynthia
The price is €143
includes taxes & fees
8 Nov - 9 Nov
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A hot tub in a covered outdoor area with a view of a swimming pool and a wooden play structure in the background.

2. Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool

Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
Fredericktown
10.0 out of 10, Exceptional, (13 reviews)
"This was one of the best stays we have ever had! The owners Cathy and Richard are absolutely incredible! They go above and beyond to make sure you have the best time possible! The amities are just non stop! I 100% recommend and will definitely be back!"
United States
Lexis
The price is €190
includes taxes & fees
11 Oct - 12 Oct
Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.

3. Sam A Baker State Park

Sam A Baker State Park
2.0 star property
Patterson
9.0 out of 10, Wonderful, (6 reviews)
"Pet friendly, great staff. "
United States
Charlie
The price is €128
includes taxes & fees
13 Oct - 14 Oct
Sam A Baker State Park
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

4. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.8 out of 10, Exceptional, (9 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
United States
Brian
The price is €90
includes taxes & fees
11 Oct - 12 Oct
The Atrium - A Boutique Hotel
A cabin interior with a loft bed, a chair, and a ceiling fan.

5. Hillside Cabin #2 Annapolis, MO Black River

Hillside Cabin #2 Annapolis, MO Black River
Annapolis
9.4 out of 10, Exceptional, (64 reviews)
"The cabin was very nice but looks a little un loved. 6 nights no tv in the evening and no reply. Looks like no one is doing up keep on the place. We did love how close we were to the river and the store. Very quite and private property. Shower curtain had a lot of mildew build up. Would give it 4 stars if it was cleaner and everything worked."
United States
Tim S.
The price is €197
includes taxes & fees
11 Oct - 12 Oct
Hillside Cabin #2 Annapolis, MO Black River
A compact kitchen with wooden cabinets, a large TV, and various kitchen utensils hanging on the wall.

6. FS Rental #4 Annapolis, MO Black River

FS Rental #4 Annapolis, MO Black River
Annapolis
9.4 out of 10, Exceptional, (10 reviews)
"Loved the cabin and the outdoor seating area. Definitely recommend for anyone traveling in the area. "
United States
Corey M.
The price is €186
includes taxes & fees
11 Oct - 12 Oct
FS Rental #4 Annapolis, MO Black River
A nighttime outdoor setting with a fire pit, a wooden structure with lights, and a red building in the background.

7. Cozy hobby farm cabin under the stars!

Cozy hobby farm cabin under the stars!
Patterson
9.6 out of 10, Exceptional, (12 reviews)
"Easy check in, very quiet, very calming and relaxing. Overall great stay and great property manager. "
United States
Wyatt S.
The price is €112
includes taxes & fees
2 Nov - 3 Nov
Cozy hobby farm cabin under the stars!
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

8. Urban Lofts

Urban Lofts
3.0 star property
Perryville
9.4 out of 10, Exceptional, (22 reviews)
"Beautiful place and staff was amazing!"
United States
Grace
The price is €277
includes taxes & fees
11 Oct - 12 Oct
Urban Lofts
A table with two chairs under a large tree with a potted plant on it.

9. Pickleball Cafe & Micro Hotel

Pickleball Cafe & Micro Hotel
Ironton
10.0 out of 10, Exceptional, (32 reviews)
"Great place to get away. Loved the coffee . "
United States
Craig C.
The price is €207
includes taxes & fees
12 Oct - 13 Oct
Pickleball Cafe & Micro Hotel
A kitchen with wooden cabinets, a toaster, and a dishwasher.

10. Lake Road Cabin C — Million Dollar Ozark View!

Lake Road Cabin C — Million Dollar Ozark View!
Ironton
10.0 out of 10, Exceptional, (32 reviews)
"Great cabin. Very quiet area. Nice fire pit."
United States
Heather the Librarian
The price is €164
includes taxes & fees
21 Oct - 22 Oct
Lake Road Cabin C — Million Dollar Ozark View!
A kitchen with wooden cabinets, a central island with stools, a microwave, a refrigerator, and a stove.

11. Hillside Cabin #1 Annapolis, MO Black River

Hillside Cabin #1 Annapolis, MO Black River
Annapolis
9.6 out of 10, Exceptional, (41 reviews)
"Very grateful for this safe clean cabin. We were there during the terrible Black River flooding and thankfully this cabin was in safe high ground. "
United States
Leslie
The price is €233
includes taxes & fees
11 Oct - 12 Oct
Hillside Cabin #1 Annapolis, MO Black River
A modern living room with a sofa, a coffee table, and a TV mounted on the wall.

12. Mountain View at Pickle & Perk

Mountain View at Pickle & Perk
Ironton
10.0 out of 10, Exceptional, (29 reviews)
"Perfect getaway, great experience. Hosts are phenomenal, food and coffee drinks are excellent. Highly recommend."
United States
Anonymous traveller
The price is €189
includes taxes & fees
12 Oct - 13 Oct
Mountain View at Pickle & Perk
A modern room with a large window, two chairs, a small wooden table, and a view of a forest.

13. RIVER and SKY Cabin; Hot Tub

RIVER and SKY Cabin; Hot Tub
Fredericktown
9.4 out of 10, Exceptional, (6 reviews)
"Great getaway"
United States
Anonymous traveller
RIVER and SKY Cabin; Hot Tub
A kitchen with wooden cabinets, a microwave, a coffee maker, a stove, and a sink.

14. Clearwater Lake, cabin minutes from Bluff View Marina & boat dock

Clearwater Lake, cabin minutes from Bluff View Marina & boat dock
Piedmont
10.0 out of 10, Exceptional, (47 reviews)
"Would stay here again"
United States
Steve A.
The price is €135
includes taxes & fees
21 Oct - 22 Oct
Clearwater Lake, cabin minutes from Bluff View Marina & boat dock
A window with a vase of flowers and a book on a wooden table.

15. The Sutton House 2 blocks from Main Street & Courthouse Square

The Sutton House 2 blocks from Main Street & Courthouse Square
Ironton
10.0 out of 10, Exceptional, (63 reviews)
"This property is beautiful and everything is thought of for the guests. The hosts were amazing. It is close to wonderful state parks. My family had a great time. I would stay here again!"
United States
Jennifer D.
The price is €187
includes taxes & fees
26 Oct - 27 Oct
The Sutton House 2 blocks from Main Street & Courthouse Square
A cozy living room with a brown leather sofa, a small table with a lamp, and a wooden floor. A kitchen with wooden cabinets and a dining area with a table and chairs are visible in the background.

16. Small Town Lodge - Annapolis, MO Black River

Small Town Lodge - Annapolis, MO Black River
Annapolis
8.4 out of 10, Very good, (9 reviews)
"Owner communicated well and the place was a nice clean place for us to stay "
United States
Jeremy H.
The price is €220
includes taxes & fees
11 Oct - 12 Oct
Small Town Lodge - Annapolis, MO Black River
A dining area with a table and chairs, wooden cabinets, and a kitchen with an archway.

17. Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.

Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
Lesterville
9.0 out of 10, Wonderful, (20 reviews)
"Ellen is a Very communicative and helpful host. Property looks even better in person than in the pictures. Enjoyable stay!"
United States
Robert H.
The price is €464
includes taxes & fees
21 Oct - 22 Oct
Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
A porch with four green Adirondack chairs, a small table, and string lights.

18. *State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch

*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
Ironton
10.0 out of 10, Exceptional, (41 reviews)
"Great place to stay!"
United States
Derek R.
The price is €275
includes taxes & fees
14 Oct - 15 Oct
*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
A wooden deck with two Adirondack chairs and a hammock.

19. Tiny Houses of French Village

Tiny Houses of French Village
2.5 star property
French Village
10.0 out of 10, Exceptional, (6 reviews)
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
United States
Chris
The price is €277
includes taxes & fees
12 Oct - 13 Oct
Tiny Houses of French Village
A spacious living room with a fireplace, a ceiling fan, and a large window.

20. AV Bungalows #1 with Loft

AV Bungalows #1 with Loft
Arcadia
9.6 out of 10, Exceptional, (5 reviews)
"The host was incredibly responsive and helpful. And for full transparency, we did not ask the host about this while we were there; however, the hot water in the showers was lukewarm at best. The hot water in the rest of the home was very warm. Also, the loft area was such a unique space. The kids loved it! Unfortunately, we were there when temperatures were in the single digits, so we needed to run the heat. ALL of it settled in the loft, leaving it much cooler everywhere else. The layout and...
United States
Tina T.
The price is €265
includes taxes & fees
11 Oct - 12 Oct
AV Bungalows #1 with Loft
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"we loved everything, rooms was super clean, staff was excellent 👌"
Moinea L 1-night trip
Posted less than an hour ago
Drury Plaza Hotel Cape Girardeau Conference Center

Find out more about Southeast Missouri

Everything you need to know about Southeast Missouri holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, apart-hotels, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Southeast Missouri holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Southeast Missouri holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Southeast Missouri holiday rentals we have selected for you start as low as €85 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Southeast Missouri rentals

At Expedia, we put the best Southeast Missouri holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

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