Southeast Missouri Holidays

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Top hotels in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is €96 per night from 10 May to 11 May
€96
10 May - 11 May
includes taxes & fees
9.6/10 Exceptional! (1,002 reviews)
This is my home away from home place! You get free dinner and the BEST breakfast buffet ever with your stay! Plus the indoor pool and hot tub! There is a thermostat in every room to control requirement. It’s just simply the best hotel ever seriously I absolutely love staying here!!!

Reviewed on 18 Apr 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is €109 per night from 7 May to 8 May
€109
7 May - 8 May
includes taxes & fees
9.6/10 Exceptional! (1,005 reviews)
👍

Reviewed on 19 Apr 2026

Drury Inn & Suites Sikeston, MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is €56 per night from 5 May to 6 May
€56
5 May - 6 May
includes taxes & fees
8/10 Very Good! (1,005 reviews)
I get it is cheap, but It shouldn’t small like feet. The room smelled bad, the hallway also, the walls are thin u can hear any noise. Never again

Reviewed on 26 Apr 2026

Baymont Inn and Suites by Wyndham Farmington, MO
See all 657 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Rocky Falls

K Bridge Recreation Area

Explore the great outdoors at K Bridge Recreation Area, a lovely green space in Annapolis. While you're in the area, stroll along the riverfront.

K Bridge Recreation Area

What to do in Southeast Missouri

Castle Entrance

History Tour of Pythian Castle in Springfield Missouri

€11
per adult
90% of travellers recommend
History Tour of Pythian Castle in Springfield Missouri
Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

€17
per adult
100% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Ozark Craft Beverage - Brewery Tour

€135
per adult
Ozark Craft Beverage - Brewery Tour
See all activities in Southeast Missouri

Frequently asked questions

Can I cancel my flight booking to Southeast Missouri due to COVID-19?
Many airlines now offer greater flexibility due to COVID-19. Our handy Customer Service Portal will help you answer most queries about which policies apply to your Southeast Missouri flight. It's also wise to check the terms and conditions of your fare — preferably before locking in your tickets!
What's the best way to find cheap flights to Southeast Missouri that have flexible change policies?
It's as easy as counting to three with Expedia. Step 1: Enter your travel details and click on the "Search" button. Step 2? Check "No change fee" directly underneath the "Flexible change policies" filter to the left of your screen. Step 3. Book your flexible and cheap ticket to Southeast Missouri.
What are some of the general tips for travellers to Southeast Missouri during the COVID-19 outbreak?
With new rules, restrictions and safety measures to adhere to, travel looks a little different right now. Here's what you should know before you hop on that plane to Southeast Missouri:
  • Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight.
  • When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry.
  • Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection.
  • One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning.
  • Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Southeast Missouri?
Contour Aviation is a major airline servicing Southeast Missouri. Search for a fare to Waynesville Regional Airport (TBN) and you'll have 56 Contour Aviation flights a month to pick from.
How can I find cheap tickets to Southeast Missouri?
You'll always score an unbeatable deal with Expedia, but our "flexible dates" search function makes it that much easier. Enter your preferred flight date, then tick the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Southeast Missouri in the last seven days.
How much is a flight to Southeast Missouri?
If you were jetting one way from (), you could've snapped up a cheap fare for just in the last seven days. Return flights to Southeast Missouri ranged from to over the same period.
What are the most popular airports to fly into in Southeast Missouri?
Southeast Missouri's main entryway is Waynesville Regional Airport (TBN). Get your next big journey underway by reserving a ticket on one of the 56 flights a month to this destination.
When is the cheapest time to fly to Southeast Missouri?
If you'd rather spend your holiday savings enjoying the best of Southeast Missouri rather than on your flight there, depart earlier in the week. The most cost-effective day to travel is normally Tuesday, with Monday a close second. With many folks travelling on the weekend, Saturday often has the highest airfares.
How much is a plane ticket to Southeast Missouri?
In the last seven days, plane tickets varied between and . Browse through our fantastic deals to Southeast Missouri, make a booking and then start packing your things!
Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented new rules and standards to help their passengers fly with extra peace of mind. Check out what these carriers are doing:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.