Cheap flights from Panama starting at €157

View €157 flight on Sun, 15 Feb 2026Opens in a new window

Popular airlines from Panama

  • Avianca

    Avianca

  • United

    United

  • American Airlines

    American Airlines

  • Delta

    Delta

  • Copa

    Copa

  • Aeromexico

    Aeromexico

  • Turkish Airlines

    Turkish Airlines

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Cheapest flights from Panama

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Sun, 18 Jan - Thu, 22 Jan
PTY
Panama City
MDE
Medellin
€298 Return, found 1 day ago
€298
Return
found 1 day ago
Select Copa flight, departing Sun, 18 Jan from Panama City to Medellin, returning Thu, 22 Jan, priced at €298 found 1 day ago
Copa
Tue, 10 Feb - Fri, 13 Feb
PTY
Panama City
MDE
Medellin
€308 Return, found 5 days ago
€308
Return
found 5 days ago
Select Copa flight, departing Tue, 10 Feb from Panama City to Medellin, returning Fri, 13 Feb, priced at €308 found 5 days ago
Copa
Sun, 18 Jan - Thu, 22 Jan
PTY
Panama City
MDE
Medellin
€312 Return, found 1 day ago
€312
Return
found 1 day ago
Select Copa flight, departing Sun, 18 Jan from Panama City to Medellin, returning Thu, 22 Jan, priced at €312 found 1 day ago
Copa
Sun, 18 Jan - Thu, 22 Jan
PTY
Panama City
MDE
Medellin
€322 Return, found 1 day ago
€322
Return
found 1 day ago
Select Copa flight, departing Sun, 18 Jan from Panama City to Medellin, returning Thu, 22 Jan, priced at €322 found 1 day ago
Copa
Sun, 18 Jan - Thu, 22 Jan
PTY
Panama City
MDE
Medellin
€330 Return, found 1 day ago
€330
Return
found 1 day ago
Select Copa flight, departing Sun, 18 Jan from Panama City to Medellin, returning Thu, 22 Jan, priced at €330 found 1 day ago
Copa
Sun, 18 Jan - Thu, 22 Jan
PTY
Panama City
MDE
Medellin
€335 Return, found 1 day ago
€335
Return
found 1 day ago
Select Copa flight, departing Sun, 18 Jan from Panama City to Medellin, returning Thu, 22 Jan, priced at €335 found 1 day ago
avianca
Tue, 10 Feb - Fri, 13 Feb
PTY
Panama City
MDE
Medellin
€366 Return, found 5 days ago
€366
Return
found 5 days ago
Select avianca flight, departing Tue, 10 Feb from Panama City to Medellin, returning Fri, 13 Feb, priced at €366 found 5 days ago
American Airlines
Wed, 2 Sept - Wed, 9 Sept
PTY
Panama City
MIA
Miami
€396 Return, found 15 hours ago
€396
Return
found 15 hours ago
Select American Airlines flight, departing Wed, 2 Sept from Panama City to Miami, returning Wed, 9 Sept, priced at €396 found 15 hours ago
United
Mon, 30 Mar - Thu, 2 Apr
PTY
Panama City
MIA
Miami
€414 Return, found 5 hours ago
€414
Return
found 5 hours ago
Select United flight, departing Mon, 30 Mar from Panama City to Miami, returning Thu, 2 Apr, priced at €414 found 5 hours ago
Aeromexico
Fri, 13 Feb - Fri, 20 Feb
PTY
Panama City
MIA
Miami
€584 Return, found 2 days ago
€584
Return
found 2 days ago
Select Aeromexico flight, departing Fri, 13 Feb from Panama City to Miami, returning Fri, 20 Feb, priced at €584 found 2 days ago

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