A red train on tracks, palm trees, and modern buildings.

Central San Diego Hotel Guide - Hotels with Spa in Central San Diego, San Diego

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Check availability on Central San Diego Hotels with Spa

Tonight
24 Sept - 25 Sept
Tomorrow
25 Sept - 26 Sept
This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Our top choices for Central San Diego hotels with a spa

A hotel with a curved entrance, palm trees, and a parking lot.
A bar area with wooden chairs and tables, a bar counter with various bottles, and a sign reading "BEACH BUMS CATER HERE".
A spacious lobby with a central round table, a reception desk, and a bar area.
A resort with a large swimming pool surrounded by lounge chairs and palm trees.

1. Handlery Hotel

Handlery Hotel
Mission Valley
  • Surrender to spa treatments and poolside luxury at this hotel with massage rooms and a beautiful heated outdoor pool and hot tub.
€104
includes taxes & fees
29 Sept - 30 Sept
Handlery Hotel
A modern bathroom with a shower, a towel rack, and a bench.
A modern interior with wooden panel ceilings, patterned seating, and a central bar area.
A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.
A pathway leading to a building labeled "LEGACY Hotel."

2. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
Mission Valley
  • Indulge in a serene escape at this upscale hotel with a full-service spa, outdoor pool with free cabanas, and couples massage treatments.
€158
includes taxes & fees
29 Sept - 30 Sept
Legacy Resort Hotel & Spa
A spa room with a bed, a bathtub, and a large window with curtains. There are candles and plants on the windowsill.
A poolside view with a lounge chair, a towel, a tray with a drink and a coconut, and a pool with palm trees in the background.
An outdoor seating area with a canopy, lounge chairs, and a fire pit.
A modern dining area with a glass table, candles, and wicker chairs.

3. San Diego Mission Bay Resort

San Diego Mission Bay Resort
Mission Bay
  • Unwind at this bay-view resort offering garden massages, poolside lounging, and a rejuvenating full-service spa retreat.
€298
includes taxes & fees
19 Oct - 20 Oct
San Diego Mission Bay Resort
A spacious indoor area with large windows overlooking the ocean, featuring modern furniture and a wooden floor.
A covered balcony with a view of the beach, featuring a railing, a table with chairs, and a bottle of wine.
A poolside area with sun loungers and white canopies, palm trees in the background, and a clear sky.
A sunlit outdoor area with a curved staircase leading to a beach view, outdoor seating, and a palm tree.

4. La Jolla Beach and Tennis Club

La Jolla Beach and Tennis Club
La Jolla Shores
  • Mediterranean beachfront wellness awaits with private spa cabanas, golf course, and beach access for total rejuvenation.
€239
includes taxes & fees
20 Oct - 21 Oct
La Jolla Beach and Tennis Club
A modern building with a sloped roof and large windows, surrounded by palm trees and a well-maintained garden.
A spacious lobby with a high ceiling, stone flooring, and wicker furniture.
An outdoor patio with round tables and chairs, large umbrellas, and a marina view in the background.
A restaurant with high ceilings, large windows, and a patterned carpet. Tables are set with chairs and place settings.

5. Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
Point Loma
  • Blissful bay views and relaxing massages set the scene for a restorative escape at this waterfront sanctuary with bubbling hot tubs.
€143
includes taxes & fees
25 Oct - 26 Oct
Best Western Plus Island Palms Hotel & Marina
An aerial view of a resort with a central swimming pool, palm trees, and a view of the ocean and beach.
An outdoor dining area with tables and chairs, umbrellas, and string lights against a sunset backdrop.
A waterfront hotel with a dock, palm trees, and a view of the water.
A modern building with a curved roof, surrounded by lush tropical vegetation.

6. Paradise Point Resort & Spa

Paradise Point Resort & Spa
Mission Bay
  • Immerse in waterfront tranquility with hot stone massages and aromatherapy at this resort spa retreat.
€248
includes taxes & fees
25 Oct - 26 Oct
Paradise Point Resort & Spa
A spacious lobby with a reception desk, seating area, and artwork on the walls.
A resort pool with a lazy river, palm trees, and a view of the ocean.
A modern hotel room with a large window offering a view of the sea, a sofa, a dining table, and a TV on a wooden cabinet.
A hotel entrance with a covered walkway, palm trees, and a modern building in the background.

7. Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
Mission Bay
  • Experience coastal tranquility at this spa hotel with bay views, heated pools, and waterslides.
€247
includes taxes & fees
30 Sept - 1 Oct
Hyatt Regency Mission Bay Spa and Marina
A spacious lobby with a marble reception desk, comfortable seating, and potted plants.
A pool area with umbrellas, palm trees, and a view of the ocean.
A balcony with a view of the ocean, palm trees, and outdoor seating.
A hotel balcony with a curved railing, outdoor seating, and palm trees.

8. Pacific Terrace Hotel

Pacific Terrace Hotel
Pacific Beach
  • Escape to a beachfront wellness sanctuary with heated pool, private spa services, and ocean-view hot tub for a serene coastal retreat.
€270
includes taxes & fees
14 Oct - 15 Oct
Pacific Terrace Hotel
A couple standing in a lobby with a display of vases and plants.
A modern bar area with a curved counter, multiple bar stools, and a large window offering a view of the cityscape.
An outdoor patio area with seating arrangements, including sofas, chairs, and round tables.
A rooftop lounge area with outdoor seating, a pool, and umbrellas.

9. Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
Downtown San Diego
  • Rooftop spa retreat delivers poolside massages and soothing therapies in the heart of city centre San Diego.
€225
includes taxes & fees
27 Sept - 28 Sept
Omni San Diego Hotel at the Ballpark
A dining area with a checkered floor, wooden chairs, a marble table, and a view of tropical foliage through large windows.
An aerial view of a coastal city with a marina, beachfront hotels, and a prominent hotel with a large balcony overlooking the ocean.
A couple walking through a wooden door into a building with a tropical garden view.
An outdoor patio with seating, a fire pit, and a view of the ocean.

10. Catamaran Resort and Spa

Catamaran Resort and Spa
Mission Beach
  • Luxurious beachside retreat offers 10 spa treatment rooms, waterfront yoga, and a serene bay location for ultimate wellness.
€248
includes taxes & fees
25 Oct - 26 Oct
Catamaran Resort and Spa
View all properties

Choose what matters most at spa hotels in Central San Diego

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Central San Diego Hotel Reviews

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

8/10 Good
"You get basic service"
Silvestre 2-night trip
Posted 1 hour ago
Hampton Inn San Diego/Mission Valley
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

10/10 Excellent
"Front desk staff was so welcoming and helpful even with last minute late night check out. Courtyard was beautiful. Property and room was modern, quiet and nicely maintained. It would be even better if there was easily visible signage from car at night for 1st floor rooms and if there was a ramp instead of the few steps. My room was facing courtyard at right rear of property with view of parking lot."
Katherine 1-night trip
Posted 4 hours ago
Crowne Plaza San Diego - Mission Valley by IHG
California Suites Hotel

California Suites Hotel

10/10 Excellent
"Excellent"
Keven 3-night trip
Posted 10 hours ago
California Suites Hotel
Kings Inn San Diego

Kings Inn San Diego

10/10 Excellent
"CLEAN ROOM OUTDOOR POOL"
George 1-night trip
Posted 18 hours ago
Kings Inn San Diego
The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

10/10 Excellent
"Everything was nice, would recommend"
Ryan 4-night trip
Posted 20 hours ago
The Alcala Hotel Mission Valley/Seaworld
The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo

8/10 Good
"The lobby was clean and the staff was nice. My unit was upstairs and it was clean and smelled really good too the only thing was the bathroom doesn’t have a working fan so I showered with the window open….you’re welcome."
Robert 1-night trip
Posted 2 days ago
The Atwood Hotel San Diego - SeaWorld/Zoo
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

10/10 Excellent
"Affordability and location can’t be beat. Staff is extremely helpful and attentive, and the amenities are great."
Karla 1-night trip
Posted 2 days ago
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

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