A red train on tracks, palm trees, and modern buildings.

Central San Diego Hotel Guide - Hotels with Spa in Central San Diego, San Diego

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Check availability on Central San Diego Hotels with Spa

Our top choices for Central San Diego hotels with a spa

A hotel lobby with leather armchairs, a sofa, and a reception desk.

1. Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
Kearny Mesa
9.2 out of 10, Wonderful, (1,011 reviews)
"Fantastic hotel with very friendly staff"
United States
Jeffrey
The price is €122
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn San Diego-Kearny Mesa
A modern reception desk with a wooden panel backdrop and illuminated signage.

2. TownePlace Suites by Marriott San Diego Central

TownePlace Suites by Marriott San Diego Central
3.0 star property
Kearny Mesa
9.0 out of 10, Wonderful, (645 reviews)
"Great hotel all around!"
United States
Eduardo
The price is €185
includes taxes & fees
28 Nov - 29 Nov
TownePlace Suites by Marriott San Diego Central
A modern bar area with wooden ceiling beams, bar stools, and a long counter.

3. Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central
3.0 star property
Kearny Mesa
8.8 out of 10, Excellent, (1,006 reviews)
"Great staff, clean rooms and excellent location"
United States
Ahmad
The price is €139
includes taxes & fees
22 Nov - 23 Nov
Courtyard by Marriott San Diego Central
A spacious lobby with a high ceiling, modern furniture, and a fireplace.

4. Four Points by Sheraton San Diego

Four Points by Sheraton San Diego
3.5 star property
Kearny Mesa
8.4 out of 10, Very good, (1,003 reviews)
"Wonderful Weekend, hotel was nice and clean."
United States
Lucy
The price is €149
includes taxes & fees
11 Nov - 12 Nov
Four Points by Sheraton San Diego
A modern hotel with a glass entrance, outdoor seating, and palm trees.

5. Hilton Garden Inn San Diego Mission Valley Stadium

Hilton Garden Inn San Diego Mission Valley Stadium
3.0 star property
Kearny Mesa
8.0 out of 10, Very good, (1,010 reviews)
"Overall, our stay was great!"
United States
Willy
The price is €126
includes taxes & fees
22 Nov - 23 Nov
Hilton Garden Inn San Diego Mission Valley Stadium
Room

6. Extended Stay America Suites San Diego Mission Valley Stadium

Extended Stay America Suites San Diego Mission Valley Stadium
2.5 star property
Kearny Mesa
6.6 out of 10, (1,003 reviews)
"Room was clean, staff was great and its in a convenient location."
United States
Brenda
The price is €109
includes taxes & fees
6 Dec - 7 Dec
Extended Stay America Suites San Diego Mission Valley Stadium
A bar area with a glass ceiling, a central bar counter, and multiple stools.

7. Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (2,135 reviews)
"Beautiful hotel with wonderful staff! I have already booked my next stay. I would highly recommend this hotel."
United States
Heather
The price is €282
includes taxes & fees
10 Nov - 11 Nov
Lafayette Hotel & Club
An outdoor seating area with a fire feature, white chairs, and potted plants.

8. Springhill Suites San Diego Mission Valley

Springhill Suites San Diego Mission Valley
3.5 star property
Mission Valley
9.2 out of 10, Wonderful, (1,002 reviews)
"Lovely stay, definitely will be back!"
United States
Kaliyah
The price is €166
includes taxes & fees
23 Nov - 24 Nov
Springhill Suites San Diego Mission Valley
An outdoor patio with wicker furniture, a stone fire pit, and blue umbrellas.

9. HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa
3.0 star property
Sorrento Valley
9.2 out of 10, Wonderful, (1,008 reviews)
"Overall great location, staff, and room"
United States
Melissa
The price is €135
includes taxes & fees
15 Nov - 16 Nov
HYATT house San Diego/Sorrento Mesa
A spacious lobby with a central seating area, a reception desk, and a staircase leading to an upper level.

10. Courtyard by Marriott San Diego Miramar

Courtyard by Marriott San Diego Miramar
3.0 star property
Miramar
8.8 out of 10, Excellent, (1,002 reviews)
"Decent Hotel"
United States
Jignesh
The price is €148
includes taxes & fees
15 Nov - 16 Nov
Courtyard by Marriott San Diego Miramar
A living room with a sectional sofa, a wooden coffee table, a blue ottoman, a wooden chair with cushions, a built-in bookshelf, and a stone wall with a fireplace.

11. Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA
3.0 star property
Sorrento Valley
9.0 out of 10, Wonderful, (1,763 reviews)
"Had a great stay!"
United States
Terrance
The price is €139
includes taxes & fees
22 Nov - 23 Nov
Country Inn & Suites by Radisson, San Diego North, CA
A hotel entrance with a stone archway, a reception desk, and potted plants.

12. Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
Mission Hills
9.2 out of 10, Wonderful, (1,102 reviews)
"Great family hotel. Simple and clean yummy breakfast inexpensive and perfect for our short stay in sd"
United States
Alejandra
The price is €140
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express San Diego Airport - Old Town by IHG
An outdoor seating area with a pergola, tables, and chairs, and a sign welcoming to the Cosmopolitan Restaurant.

13. Cosmopolitan Hotel & Restaurant

Cosmopolitan Hotel & Restaurant
2.5 star property
Old Town San Diego
9.2 out of 10, Wonderful, (773 reviews)
"Great atmosphere! Perfect place to enjoy all of Old town San Diego"
United States
Alan
The price is €171
includes taxes & fees
10 Nov - 11 Nov
Cosmopolitan Hotel & Restaurant
A modern lobby with a round table and four chairs, a reception desk, and a large window.

14. San Diego Marriott Mission Valley

San Diego Marriott Mission Valley
4.0 star property
Mission Valley
8.8 out of 10, Excellent, (1,016 reviews)
"The trolley that's just across the street from the hotel was amazing and convenient!"
United States
Eva
The price is €164
includes taxes & fees
15 Nov - 16 Nov
San Diego Marriott Mission Valley
A poolside area with lounge chairs, a fire pit, and string lights.

15. Hyatt Regency La Jolla

Hyatt Regency La Jolla
4.0 star property
University City
9.0 out of 10, Wonderful, (1,002 reviews)
"Grace was amazing! She helped so much and was so sweet!! Can’t wait to go back and stay there again!"
United States
Priya
The price is €243
includes taxes & fees
20 Nov - 21 Nov
Hyatt Regency La Jolla
A modern reception area with two reception desks, a green wall, and pendant lighting.

16. Element by Marriott San Diego Mission Valley

Element by Marriott San Diego Mission Valley
3.0 star property
Mission Valley
8.8 out of 10, Excellent, (130 reviews)
"Very clean, healthy breakfast, chef was very friendly, comfortable beds, spacious and great location."
United States
Michelle
The price is €166
includes taxes & fees
15 Nov - 16 Nov
Element by Marriott San Diego Mission Valley
A modern reception area with a stone wall, a blue sofa, and a reception desk.

17. Kings Inn San Diego

Kings Inn San Diego
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (3,847 reviews)
"Loved this hotel and will be back!"
United States
james
The price is €80
includes taxes & fees
10 Nov - 11 Nov
Kings Inn San Diego
An outdoor patio with a fire feature, seating, and string lights.

18. Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla
4.0 star property
University City
8.8 out of 10, Excellent, (2,134 reviews)
"Nice a friendly staff! Great hotel in beautiful La Jolla!"
United States
Tristan
The price is €173
includes taxes & fees
20 Nov - 21 Nov
Embassy Suites by Hilton San Diego La Jolla
A patio area with a circular fire pit surrounded by wicker furniture and a stone wall.

19. Courtyard by Marriott San Diego Sorrento Valley

Courtyard by Marriott San Diego Sorrento Valley
3.0 star property
Sorrento Valley
8.8 out of 10, Excellent, (1,002 reviews)
"Nice hotel."
United States
KATHERINE
The price is €157
includes taxes & fees
20 Nov - 21 Nov
Courtyard by Marriott San Diego Sorrento Valley
A hotel reception area with a reception desk, framed pictures on the wall, a clock, and a seating area with a table and chairs.

20. Pleasant Inn

Pleasant Inn
2.5 star property
Clairemont
8.6 out of 10, Excellent, (1,637 reviews)
"Clean rooms and Great Staff."
United States
Daniel
The price is €78
includes taxes & fees
26 Nov - 27 Nov
Pleasant Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Central San Diego

Pool
Breakfast included

Top Central San Diego Hotel Reviews

The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo

10/10 Excellent
"Everyone was very friendly. Our room was just as described and they went the extra mile to provide a shower chair for me. Could not have been more perfect for us."
Jennifer 6-night trip
Posted 10 hours ago
The Atwood Hotel San Diego - SeaWorld/Zoo

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