Esquilino Hotel Guide - Luxury Hotels in Esquilino, Rome

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Our top choices for Esquilino luxury hotels

Exterior
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento
5.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (1000)
"The hotel was the best location to be at. Amazing stay and so convenient."
United States
Jalin
The price is €292
includes taxes & fees
10 Jan - 11 Jan 2026
NH Collection Roma Palazzo Cinquecento
Balcony
Doria Palace Boutique Hotel

Doria Palace Boutique Hotel

Doria Palace Boutique Hotel
4.0 star property
Rome City Centre
8.8 out of 10, Excellent, (79)
"Staff were very helpful. Property was clean and the bed was comfy. Would have been nice to have some water/milk in the room for tea/coffee. Area is convenient, 15/20 min walk from most attractions. Molino opposite was very good for breakfast/dinner. "
United Kingdom
Megan
The price is €132
includes taxes & fees
6 Jan - 7 Jan 2026
Doria Palace Boutique Hotel
Romantic Suite, Terrace
Mecenate Palace

Mecenate Palace

Mecenate Palace
4.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (1003)
"We have been here twice. The staff is very friendly it’s close to everything and very clean "
Canada
Joseph
The price is €142
includes taxes & fees
6 Jan - 7 Jan 2026
Mecenate Palace
Daily buffet breakfast (EUR 16 per person)
Best Western Hotel President

Best Western Hotel President

Best Western Hotel President
4.0 star property
Rome Historic Centre
8.6 out of 10, Excellent, (1002)
"Good location, slightly removed from tourist packs."
United States
Michael
The price is €125
includes taxes & fees
9 Jan - 10 Jan 2026
Best Western Hotel President
Front of property
Napoleon Hotel

Napoleon Hotel

Napoleon Hotel
4.0 star property
Rome City Centre
8.4 out of 10, Very good, (1001)
"Perfect location and great breakfast."
United States
Marcia
Napoleon Hotel
Double Room, Jetted Tub
Mercure Roma Centro St. John

Mercure Roma Centro St. John

Mercure Roma Centro St. John
4.0 star property
Rome Historic Centre
7.8 out of 10, Good, (209)
"Great location. Helpful staff and nice breakfast offered for a fee. Rooms were clean and very nice. "
United States
Sandra
The price is €120
includes taxes & fees
16 Dec - 17 Dec
Mercure Roma Centro St. John
Daily cooked-to-order breakfast (EUR 10 per person)
Hotel Aphrodite

Hotel Aphrodite

Hotel Aphrodite
4.0 star property
Rome City Centre
7.6 out of 10, Good, (1001)
"Very covenient loaction to train station."
Canada
Terri
The price is €114
includes taxes & fees
14 Dec - 15 Dec
Hotel Aphrodite
Exterior
Relais Manzoni

Relais Manzoni

Relais Manzoni
4.0 star property
Rome Historic Centre
8.2 out of 10, Very good, (215)
"I really liked the staff Francesca was so helpful and so nice. The madam that served breakfast was so gracious. They went out of their way to be kind. "
Canada
Rachelle
Relais Manzoni
Free daily buffet breakfast
Hotel Best Roma

Hotel Best Roma

Hotel Best Roma
4.0 star property
Rome Historic Centre
7.6 out of 10, Good, (455)
"Excelent hotel it’s near to the Metro that connects you to all the attractions. The food was really good "
United States
Emilia
The price is €111
includes taxes & fees
19 Dec - 20 Dec
Hotel Best Roma
Exterior
Champagne Palace Hotel

Champagne Palace Hotel

Champagne Palace Hotel
4.0 star property
Rome City Centre
6.0 out of 10, (1000)
"Staffs were friendly "
United States
sarah
The price is €90
includes taxes & fees
9 Jan - 10 Jan 2026
Champagne Palace Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Esquilino Hotel Reviews

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Frequently asked questions

Are you searching for the perfect hotel for your luxury holiday in Esquilino?
During your visit, you might want to enjoy the sightseeing and museums which Esquilino is known for.
What's the best luxury place to stay in Esquilino?
NH Collection Roma Palazzo Cinquecento is a luxury hotel with a rooftop terrace and a deli, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Another upscale choice for your trip is Mirko Luxury Inn.
What's there to see and do in Esquilino?
Enjoy all that Esquilino has to offer when you visit Piazza Vittorio Emanuele II, Piazza Santa Maria Maggiore and Basilica di Santa Croce in Gerusalemme. If you have a bit of extra time while you're in the area, you might want to check out Via Marsala and Historic Museum of the Liberation.
How can I get around Esquilino?
It's easier to get around town comfortably when you know your options. You can access metro transport at S Bibiana Station, Vittorio Emanuele Station and Manzoni - Museo della Liberazione Station.