San Diego Hotel Guide. Hotels in Otay Mesa, San Diego, United States of America

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Check prices for these dates

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10 Nov - 11 Nov
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11 Nov - 12 Nov
This weekend
13 Nov - 15 Nov
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20 Nov - 22 Nov

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Our top choices for Otay Mesa hotels

A breakfast station with bread, bagels, waffles, and a coffee machine.

1. Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,004 reviews)
"clean room nice place to stay"
Mexico
Anonymous traveller
The price is €111
includes taxes & fees
23 Nov - 24 Nov
Quality Suites San Diego Otay Mesa
A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

2. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.4 out of 10, Very good, (1,962 reviews)
"Good place to stay for work."
United States
Renato
The price is €141
includes taxes & fees
12 Nov - 13 Nov
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A modern living room with a large window, a fireplace, and a kitchen area.

3. Rodeway Inn San Diego South San Ysidro Border

Rodeway Inn San Diego South San Ysidro Border
2.0 star property
5.8 km from Otay Mesa
8.0 out of 10, Very good, (322 reviews)
"Great service beautiful hotel"
United States
Guadalupe
The price is €77
includes taxes & fees
17 Nov - 18 Nov
Rodeway Inn San Diego South San Ysidro Border
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

4. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,427 reviews)
"Great service from the staff!"
United States
Erika
The price is €106
includes taxes & fees
29 Nov - 30 Nov
Best Western Americana Inn
A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

5. Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very good, (2,050 reviews)
"Me and my husband loved it we tried different ones and this one is one of the best from now on is going to be our favorite to stay,very clean and breakfast was so good so many options for breakfast"
United States
Edna
The price is €108
includes taxes & fees
29 Nov - 30 Nov
Best Western Chula Vista/Otay Valley Hotel
A motel with a sign indicating amenities like Wi-Fi, TV, and pool.

6. Valli Hi Motel

Valli Hi Motel
2.0 star property
7.9 km from Otay Mesa
8.2 out of 10, Very good, (1,170 reviews)
"Clean rooms and nice staff"
United States
Wendy
The price is €82
includes taxes & fees
11 Nov - 12 Nov
Valli Hi Motel
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

7. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,800 reviews)
"Clean room , friendly staff , always helpful, breakfast good , always great to return"
United States
Luis
The price is €103
includes taxes & fees
22 Nov - 23 Nov
La Quinta Inn by Wyndham San Diego Chula Vista
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

8. The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,213 reviews)
"Solid place to stay"
United States
Neal
The price is €96
includes taxes & fees
1 Dec - 2 Dec
The Rambler Hotel
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

9. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.4 out of 10, Very good, (1,733 reviews)
"It was a nice hotel. I’d stay here again."
United States
Lori
The price is €107
includes taxes & fees
22 Nov - 23 Nov
Comfort Inn Chula Vista San Diego South
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.

10. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,030 reviews)
"I was very impressed with this hotel. The rooms were comfortable and modern and the staff was warm and welcoming."
United States
Rosemary
The price is €167
includes taxes & fees
29 Nov - 30 Nov
Ayres Hotel San Diego South - Chula Vista
A hotel room with two beds, a desk, and a chair.

11. Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South
2.0 star property
18.3 km from Otay Mesa
7.6 out of 10, Good, (1,194 reviews)
"Great stay for a stay !"
United States
Monserrat
The price is €71
includes taxes & fees
24 Nov - 25 Nov
Howard Johnson by Wyndham National City/San Diego South
A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

12. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.4 out of 10, Good, (2,463 reviews)
"Clean rooms nice staff"
United States
Wendy
The price is €63
includes taxes & fees
11 Nov - 12 Nov
Hotel Palmeras Chula Vista
View from property

13. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (822 reviews)
"Great hotel"
United States
leslie
The price is €205
includes taxes & fees
15 Nov - 16 Nov
SpringHill Suites by Marriott Chula Vista Eastlake
An outdoor seating area with fire pits, lounge chairs, and string lights against a sunset backdrop.

14. Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
17.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1,168 reviews)
"Lovely place to stay, beautiful scenery. The only downside is everything is far away- gas station, restaurants, you have to UBER or have a rental car to travel for amenities outside of what the resort offers."
United States
Josh
The price is €240
includes taxes & fees
1 Dec - 2 Dec
Loews Coronado Bay Resort
A spacious restaurant with high ceilings, exposed beams, and hanging plants. There are multiple seating areas with tables and chairs.

15. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,234 reviews)
"Clean room and really nice area for our stay"
United States
Brandon
The price is €132
includes taxes & fees
29 Nov - 30 Nov
Best Western Plus Marina Gateway Hotel
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

16. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,584 reviews)
"Really nice place"
United States
justin
The price is €109
includes taxes & fees
18 Nov - 19 Nov
Hercor Hotel - Urban Boutique
A reception area with a wooden arch, shelves with books and decorative items, and a marble counter.

17. The Davis Downtown San Diego

The Davis Downtown San Diego
3.5 star property
East Village, 24.2 km from Otay Mesa
8.0 out of 10, Very good, (636 reviews)
"Great hotel! Easy to use! Great price and location!"
United States
Robert Scott
The price is €75
includes taxes & fees
7 Dec - 8 Dec
The Davis Downtown San Diego
A swimming pool with palm trees and a mountain in the background.

18. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,222 reviews)
"Great stay!"
United States
Kimberly
The price is €100
includes taxes & fees
16 Nov - 17 Nov
Sycuan Casino Resort
A modern hotel room with a large mirror, a wooden vanity, and a bed with a view of the city.

19. Ash&9th

Ash&9th
2.0 star property
24.7 km from Otay Mesa
8.2 out of 10, Very good, (1,111 reviews)
"Great room for the price, convenient and great staff. Will stay again."
United States
Sandra
The price is €67
includes taxes & fees
30 Nov - 1 Dec
Ash&9th
A buffet with various food items, including omelets and other dishes, served in metal trays.

20. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,657 reviews)
"Great stay"
United States
Daniel
The price is €156
includes taxes & fees
8 Dec - 9 Dec
Holiday Inn Express San Diego South - Chula Vista by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Otay Mesa

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
8.4
Very good
1,962 reviews
View
A breakfast station with bread, bagels, waffles, and a coffee machine.
Quality Suites San Diego Otay Mesa
2.5 star property
7.2
Good
1,004 reviews
View
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.
Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.8
Exceptional
1,030 reviews
View
A spacious lobby with a fireplace, wooden furniture, and a chandelier.
Best Western Americana Inn
2.5 star property
8.8
Excellent
1,427 reviews
View
View from property
SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
9.6
Exceptional
822 reviews
View

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Frequently Asked Questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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