A coastal landscape with rocky cliffs, clear blue waters, and distant mountains.

San Luis Obispo Wine Country Hotel Guide - Hotels with Spa in San Luis Obispo Wine Country, California

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Check availability on San Luis Obispo Wine Country Hotels with Spa

Our top choices for San Luis Obispo Wine Country hotels with a spa

A bathroom with a stone sink, a mirror, and towels hanging on the wall.

1. Madonna Inn

Madonna Inn
3.5 star property
San Luis Obispo
9.2 out of 10, Wonderful, (1,640 reviews)
  • cleanliness
    Unwind at a unique spa retreat with six treatment rooms for aromatherapy, body scrubs, and massages in scenic comfort.
The price is €184
includes taxes & fees
24 Nov - 25 Nov
Madonna Inn
A multi-story building with balconies, a fountain, and a patio area.

2. Avila La Fonda Hotel

Avila La Fonda Hotel
4.0 star property
Avila Beach
9.6 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Revitalising seaside escape with private indoor hot tubs and spa services offers a wellness retreat just steps from the beach.
The price is €210
includes taxes & fees
8 Dec - 9 Dec
Avila La Fonda Hotel
A modern interior with a reception desk, wooden shelving, and a variety of products on display.

3. HOTEL CERRO, Autograph Collection

HOTEL CERRO, Autograph Collection
4.0 star property
Downtown San Luis Obispo
9.2 out of 10, Wonderful, (507 reviews)
  • cleanliness
    Tranquil urban retreat with steam room, rooftop garden, and holistic treatments for a restorative wellness escape.
The price is €285
includes taxes & fees
8 Dec - 9 Dec
HOTEL CERRO, Autograph Collection
A spacious lobby with a wooden ceiling, a reception desk, seating areas, and large windows offering views of the outdoors.

4. Hotel San Luis Obispo

Hotel San Luis Obispo
4.5 star property
Downtown San Luis Obispo
9.4 out of 10, Exceptional, (705 reviews)
  • cleanliness
    Savour serenity at this luxury hotel with a full-service spa offering daily treatments and couples' massage rooms in San Luis Obispo.
The price is €301
includes taxes & fees
15 Nov - 16 Nov
Hotel San Luis Obispo
A multi-story hotel with balconies, a covered walkway, and a landscaped garden area.

5. The Agrarian Hotel, BW Signature Collection

The Agrarian Hotel, BW Signature Collection
2.5 star property
Arroyo Grande
9.6 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Revitalise mind and body at this charming hotel with therapeutic spa services and a bubbling hot tub.
The price is €155
includes taxes & fees
15 Nov - 16 Nov
The Agrarian Hotel, BW Signature Collection
A bedroom with a large bed, a view of a vineyard through a sliding door, and a balcony with a table and chairs.

6. Geneseo Inn

Geneseo Inn
3.5 star property
Geneseo District
10.0 out of 10, Exceptional, (106 reviews)
  • cleanliness
    Vineyard escape at this tranquil hotel with Swedish massages, deep-tissue treatments, and on-site winery for a restorative getaway.
The price is €314
includes taxes & fees
1 Dec - 2 Dec
Geneseo Inn
A room with a dining table, chairs, a hanging plant, and a window with blinds.

7. Cayucos Sunset Inn B&B

Cayucos Sunset Inn B&B
3.5 star property
Cayucos
9.8 out of 10, Exceptional, (267 reviews)
  • cleanliness
    Relax in a beachside inn with private hot tubs, garden views, and rejuvenating couples massages.
The price is €180
includes taxes & fees
23 Nov - 24 Nov
Cayucos Sunset Inn B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in San Luis Obispo Wine Country

Pool
Breakfast included

Top San Luis Obispo Wine Country Hotel Reviews

Quality Suites Downtown San Luis Obispo

Quality Suites Downtown San Luis Obispo

10/10 Excellent
"Love staying here when I visit my son in SLO. Such a great location and very comfortable rooms. Staff are so friendly."
Allison 1-night trip
Posted 2 hours ago
Quality Suites Downtown San Luis Obispo

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