South San Francisco Hotel Guide - Business Hotels in South San Francisco, San Francisco

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on South San Francisco Business Hotels

Tonight
1 Dec - 2 Dec
Tomorrow
2 Dec - 3 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top South San Francisco Business Hotels

Exterior
Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North

3.0 star property
The East Side
8.6 out of 10, Excellent, (1024)
"Staff, amenities, clean rooms "
United States
ROMEO JR
The price is €92
includes taxes & fees
20 Dec - 21 Dec
Hilton Garden Inn San Francisco Arpt North
Bar (on property)
DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd

4.0 star property
South San Francisco
8.4 out of 10, Very good, (2033)
"Room was clean, the dinner at the restaurant was very good. "
United States
Peter
The price is €117
includes taxes & fees
1 Jan - 2 Jan 2026
DoubleTree by Hilton San Francisco South Airport Blvd
Pool
Holiday Inn Express San Francisco-Airport North by IHG

Holiday Inn Express San Francisco-Airport North by IHG

2.5 star property
South San Francisco
8.2 out of 10, Very good, (1026)
"Overall stay is excellent ✨"
United States
Chloe Nicole Badajos
The price is €87
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express San Francisco-Airport North by IHG
Lobby
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area

2.5 star property
The East Side
9.0 out of 10, Wonderful, (434)
"Clean room, helpful staff, complimentary breakfast. "
United States
Veronica
The price is €111
includes taxes & fees
6 Dec - 7 Dec
Fairfield by Marriott Inn & Suites San Francisco Airport Oyster Point Area
Lobby
Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel

3.0 star property
South San Francisco
8.4 out of 10, Very good, (1702)
"Great place to stay "
United States
Florence
The price is €93
includes taxes & fees
19 Dec - 20 Dec
Best Western Plus Grosvenor Airport Hotel
Lobby
Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront

3.0 star property
Oyster Point
8.6 out of 10, Excellent, (1866)
"always a great stay"
United States
Marco
The price is €96
includes taxes & fees
21 Dec - 22 Dec
Sonesta Select San Francisco Airport Oyster Point Waterfront
Terrace/patio
Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North

3.0 star property
The East Side
8.8 out of 10, Excellent, (1161)
"Breakfast very good and clean, quiet and relaxing "
United States
Mark
The price is €112
includes taxes & fees
19 Dec - 20 Dec
Home2 Suites by Hilton San Francisco Airport North
View from property
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

4.0 star property
Oyster Point
9.2 out of 10, Wonderful, (1009)
"Very convenient stay for San Francisco. Clean hotel and very comfortable bed. Excellent gym. Will stay again. "
United States
Andy
The price is €127
includes taxes & fees
12 Dec - 13 Dec
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Exterior
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3.0 star property
Downtown South San Francisco
8.0 out of 10, Very good, (2034)
"Hotel was good for the price. "
United States
Dominique
The price is €106
includes taxes & fees
2 Jan - 3 Jan 2026
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Bar (on property)
Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

3.5 star property
The East Side
8.6 out of 10, Excellent, (1234)
"Loved this hotel "
United States
Cheryl
The price is €153
includes taxes & fees
12 Dec - 13 Dec
Embassy Suites by Hilton San Francisco Airport Oyster Point
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top South San Francisco Hotel Reviews

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

10/10 Excellent
"Perfect location. Hotel with european feel. Lovely and clean room. A bit warm in the rooms and bed a bit too soft for our liking. Bar not open on sunday and monday. Helpfull staff. Hope to visit again."
Katherina 2-night trip
Posted 22 hours ago
Chancellor Hotel on Union Square

Explore a world of travel with Expedia

Frequently asked questions

How much do business-friendly hotels in South San Francisco cost?
Rates for business hotels in South San Francisco range between €87 and €153 per night. No matter your budget, Expedia can help you locate the best place to complete the job. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in South San Francisco?
You can pick from multiple business-friendly hotels in South San Francisco that have a total average guest review rating of 8.5. Grand Hyatt at SFO is a hit among corporate travellers. This 4-stars hotel comes with amenities such as a cafe and hypo-allergenic bedding. AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront is another highly rated option. It has a 4-stars rating and conveniences including a terrace and an electric car charging station.
How many business-friendly hotels are there in South San Francisco?
You'll find 25 business-friendly hotels in South San Francisco. Whether you're searching for conveniences like coworking spaces or dependable WiFi, trust Expedia to help you find the ideal space to get the job done.
What are the best cheap business-friendly hotels in South San Francisco?
Business-friendly hotels in South San Francisco start from €87 per night, so your work trip doesn't have to stretch the finances. Hampton Inn San Francisco Airport is a reasonably priced choice that features many amenities, like an electric car charging station and front desk services. Hampton Inn San Francisco-Daly City is another economical stay that's popular with corporate travellers. Conveniences here include front desk services and complimentary breakfast. When it's time to do a little sightseeing in South San Francisco, add some fantastic free attractions to your business trip agenda. Union Square and Westin St Francis Hotel Glass Elevators are great ways to spend a day. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the top business-friendly motels in South San Francisco?
Regency Inn SFO Airport is a great option for corporate guests who want comfort and affordability. Located around 3 kilometres south of downtown South San Francisco, front desk services and a nearby metro station are among its many amenities. Or settle in and be productive at Travellers Inn. This business-friendly property features conveniences like WiFi and front desk services and is approximately 5 kilometres west of central South San Francisco.When it's time to change from your business to casual attire and explore your surroundings, head to San Francisco Museum of Modern Art. Union Square is another highlight in South San Francisco.
Are there any family-friendly hotels in South San Francisco that are also business friendly?
The Clift Royal Sonesta San Francisco welcomes leisure and corporate guests alike. WiFi and a cafe are just the start of the amenities available at this 4-stars South San Francisco escape. Alternatively, book a break with the family and get down to work at Hotel Nikko San Francisco. You'll have access to conveniences such as a sauna and laundry facilities at this comfortable 4.5-stars property. South San Francisco has loads of family-friendly attractions to explore once work is out of the way. Take the kids on an excursion to Union Square and San Francisco Zoo.
Are there any 5-star business-friendly hotels in South San Francisco?
Make a booking at Mansion on Sutter. Around 14 kilometres from the downtown area of South San Francisco, this business-friendly hotel has a 5-star rating and amenities including Frette Italian sheets and concierge services. The St. Regis San Francisco is another 5-star pick that's ideal for corporate travellers. It's located about 14 kilometres from the city centre and comes with concierge services and Frette Italian sheets.
Why book your business-friendly hotel in South San Francisco with Expedia?
With useful amenities like room service, conference rooms and on-site restaurants, our business-friendly stays come with everything you'll need to get the job done — and then kick back! Enter your travel dates and destination and Expedia will help you with the rest.
How can I find cheap business-friendly hotels in South San Francisco?
When work takes you on the road in South San Francisco, our "business friendly" filter will help you find a suitable hotel. From dependable WiFi to meeting rooms and workspaces, they come with the amenities you need to do your job. Another tip? Refine your search by your budget and preferred star rating to see the cheapest stays.
What is there to do in South San Francisco near my business-friendly hotel?
Whatever your tastes or interests, South San Francisco has lots of things to keep you on the go. San Francisco Museum of Modern Art, Union Square and San Francisco Zoo are on most travellers' to-do lists. You shouldn't miss California Academy of Sciences, Orpheum Theatre and Westin St Francis Hotel Glass Elevators either. With Expedia's business-friendly hotel deals, you can see even more popular attractions like these with the money you save.