Mission District Hotel Guide - Boutique Hotels in Mission District, San Francisco

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mission District Boutique Hotels

Top Mission District Boutique Hotels

Indoor pool
Berkeley City Club

Berkeley City Club

2.5 star property
Berkeley
8.8 out of 10, Excellent, (690)
"Lovely, classic Berkeley hotel. We had a wonderful stay and we will be back! "
United States
Paige
Berkeley City Club
Games room
Hotel Zephyr San Francisco

Hotel Zephyr San Francisco

4.0 star property
Fisherman's Wharf
8.6 out of 10, Excellent, (2268)
"Room was nice and clean staff was nice too"
United States
Veronica
The price is €151
includes taxes & fees
23 Nov - 24 Nov
Hotel Zephyr San Francisco
Lobby sitting area
The Marker Union Square San Francisco

The Marker Union Square San Francisco

4.0 star property
Union Square
9.0 out of 10, Wonderful, (1042)
"Good location and friendly staff "
United States
Michael
The price is €142
includes taxes & fees
22 Nov - 23 Nov
The Marker Union Square San Francisco
Front of property – evening/night
Hotel Abri - Union Square

Hotel Abri - Union Square

3.5 star property
Union Square
8.6 out of 10, Excellent, (1002)
"Great staff! Great location!"
United States
Clarissa
The price is €136
includes taxes & fees
21 Nov - 22 Nov
Hotel Abri - Union Square
City view
Taj Campton Place

Taj Campton Place

5.0 star property
Union Square
9.2 out of 10, Wonderful, (1002)
"I would stay here again."
United States
Richard
The price is €202
includes taxes & fees
22 Nov - 23 Nov
Taj Campton Place
Meeting facility
The Barnes San Francisco, Tapestry Collection by Hilton

The Barnes San Francisco, Tapestry Collection by Hilton

4.0 star property
Union Square
8.2 out of 10, Very good, (751)
"Great location. Staff was wonderful."
United States
Michael
The price is €117
includes taxes & fees
28 Nov - 29 Nov
The Barnes San Francisco, Tapestry Collection by Hilton
Exterior
Argonaut Hotel

Argonaut Hotel

4.5 star property
Fisherman's Wharf
9.4 out of 10, Exceptional, (1174)
"The hotel was perfect, great location, clean and in a spot that was easy to get around Frisco! "
Canada
Catherine
The price is €219
includes taxes & fees
7 Dec - 8 Dec
Argonaut Hotel
Room (Private Apartment)
The Clift Royal Sonesta San Francisco

The Clift Royal Sonesta San Francisco

4.0 star property
Union Square
9.2 out of 10, Wonderful, (1342)
"Loved my stay here! "
United States
Naomi
The price is €206
includes taxes & fees
14 Nov - 15 Nov
The Clift Royal Sonesta San Francisco
Suite, Multiple Beds (The Two Bedroom)
Palihotel San Francisco

Palihotel San Francisco

3.5 star property
Union Square
8.4 out of 10, Very good, (614)
"Great location and beautiful historic building. "
United States
Stephanie
The price is €133
includes taxes & fees
22 Nov - 23 Nov
Palihotel San Francisco
Lobby
The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott

4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1001)
"cleanliness,good service, convenient location"
United States
Harry
The price is €199
includes taxes & fees
24 Nov - 25 Nov
The Clancy, Autograph Collection by Marriott
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mission District Hotel Reviews

The Marker Union Square San Francisco

The Marker Union Square San Francisco

10/10 Excellent
"Good location and friendly staff "
Michael 2-night trip
Posted 17 hours ago
The Marker Union Square San Francisco

Explore a world of travel with Expedia

Frequently asked questions

What's there to see and do in Mission District?
The bars is one thing to enjoy while you're in the area. Favorite activities and sights around Mission District include Pier 39, Chase Center and Oracle Park. You might also want to see places such as Alcatraz Island, Victoria Theatre and SF Armory during your trip.
What's the best way to get to my boutique hotel in Mission District?
You have a few options for getting to Mission District. The closest major airport is San Francisco International Airport (SFO), which is located 10 mi (16.1 km) away. Take advantage of metro transport at 16th Street Mission Station, 24th Street Mission Station and Right Of Way/20th St Stop.