A forested valley with autumn foliage, a rocky cliff, and a sunset.

Search Guest Houses in Southern Illinois

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
17 Jul - 19 Jul
In two weeks
24 Jul - 26 Jul
In one month
7 Aug - 9 Aug
In two months
4 Sept - 6 Sept

Our top choices for Southern Illinois guest houses

Outdoor dining

Lakefront Suite · Dock, No-Wake Cove & Firepit

Lakefront Suite · Dock, No-Wake Cove & Firepit
Marion
10.0 out of 10, Exceptional, (17 reviews)
"A short stay for us as we were passing through the area but it was very lovely! Great spot"
United States
Sam M.
The price is €319
includes taxes & fees
28 Jul - 29 Jul
Lakefront Suite · Dock, No-Wake Cove & Firepit
Smart TV

Cozy, Fun, and One-Of-A-Kind!

Cozy, Fun, and One-Of-A-Kind!
Shaw
9.4 out of 10, Exceptional, (138 reviews)
"Great place and location"
United States
Sam K.
The price is €119
includes taxes & fees
13 Jul - 14 Jul
Cozy, Fun, and One-Of-A-Kind!
Front of property

Grand Center Inn

Grand Center Inn
3.0 star property
Grand Center
9.4 out of 10, Exceptional, (103 reviews)
"Lovely room, easy check in, close to Fox, comfy bed"
United States
Leon and Janis
The price is €185
includes taxes & fees
19 Jul - 20 Jul
Grand Center Inn
Exterior

Charming Home with Country Views

Charming Home with Country Views
Grafton
10.0 out of 10, Exceptional, (44 reviews)
"Everything that was advertised and more. Charming, comfortable, very clean and we had a great stay. Perfect location for biking along the Great River Road. Highly recommend!"
United States
Cathy D.
The price is €330
includes taxes & fees
19 Jul - 20 Jul
Charming Home with Country Views
TV, video games

In the center of all Historic Main Street has to offer

In the center of all Historic Main Street has to offer
Grafton
7.0 out of 10, Good, (2 reviews)
"Such a great location! Very clean & cute house!"
United States
Janelle C.
The price is €556
includes taxes & fees
13 Jul - 14 Jul
In the center of all Historic Main Street has to offer
Private kitchen

The Mediterranean House 1858

The Mediterranean House 1858
2.0 star property
Perryville
The price is €609
includes taxes & fees
13 Jul - 14 Jul
The Mediterranean House 1858
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southern Illinois Hotel Reviews

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

10/10 Excellent
"Room was clean and the breakfast was good. Large breakfast area. The lady who took care of the breakfast area was constantly refilling and keeping the area nice. She worked the entire time and nothing ever ran low. The room was actually pretty well kept considering it’s a hotel. Parking was easy and felt safe."
Nancy 1-night trip
Posted 5 hours ago
Comfort Suites Mount Vernon

Find out more about Southern Illinois

Southern Illinois Guest Houses information

Number of reviews
304
Accommodation
4 Guest Houses
Lowest Price
€119
Highest Price
€609

Explore a world of travel with Expedia