Southern Illinois Holidays

Photo by Southernmost Illinois Tourism Bureau

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Where to stay in Southern Illinois

Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
Aerial view of the iconic Gateway Arch and Mississippi River with urban skyline and bridges, Downtown St. Louis, Missouri, United States.

Eastport

While visiting Eastport, you might make a stop by sights like Gateway Conference Center and Splash City Family Waterpark.

Find hotels in Eastport

Top hotels in Southern Illinois

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
The price is €96 per night from 12 May to 13 May
€96
12 May - 13 May
includes taxes & fees
9.2/10 Wonderful! (1,017 reviews)
Arrived late and they were very accommodating and the room was clean and comfortable.

Reviewed on 11 Apr 2026

Drury Inn & Suites St. Louis Fairview Heights
Best Western Delta Inn

Best Western Delta Inn

2.5 out of 5
1509 Hampton Dr Effingham IL
Fully refundableReserve now, pay when you stay
The price is €86 per night from 19 Apr to 20 Apr
€86
19 Apr - 20 Apr
includes taxes & fees
9.2/10 Wonderful! (1,003 reviews)
Nice clean hotel. Breakfast variety limited

Reviewed on 10 Apr 2026

Best Western Delta Inn
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
The price is €124 per night from 3 May to 4 May
€124
3 May - 4 May
includes taxes & fees
9.6/10 Exceptional! (1,002 reviews)
Very nice and clean

Reviewed on 10 Apr 2026

Drury Inn & Suites St. Louis O'Fallon, IL
See all 1,164 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Superman Statue

Superman Statue

Superman fans will love getting a photograph taken in front of this giant statue of the Man of Steel himself, dressed in his iconic red-and-blue guise.

Superman Statue

Frequently asked questions

Can I cancel my flight booking to Southern Illinois due to COVID-19?
If you haven't booked yet, check the terms and conditions of your preferred carrier. If you've already locked in your flight to Southern Illinois, click through to our Customer Service Portal. The information here will help determine which COVID-19 policies apply to your booking and advise the next steps.
What's the best way to find cheap flights to Southern Illinois that have flexible change policies?
At Expedia, we've been channeling our inner gymnast to bring you the most flexible fares around. Just click on "No change fee" under the filter heading "Flexible change policies" to find your perfect flight to Southern Illinois.
What are some of the general tips for travellers to Southern Illinois during the COVID-19 outbreak?
With new COVID-19 rules and measures to adhere to, travel looks a bit different at present. Here are some useful things to know before you hop on that plane to Southern Illinois:
  • Research the rules and restrictions in both your origin and destination. You may not be able to travel depending on local circumstances, so make sure you check before you lock in your flight.
  • Wear a face mask during airport screening. A TSA employee will ask you to temporarily lower your mask for ID purposes.
  • To minimize the risk of cross-contamination, place your boarding pass on the scanner yourself and then hold it up for inspection. Do not hand your pass directly to a TSA officer.
  • One liquid hand sanitizer container is now allowed in your carry-on baggage. It must be no larger than 12 oz (350 ml), and you'll need to take it out of your bag for X-ray scanning.
  • To reduce handling during the screening process, place items such as your phone, keys and wallet into your carry-on rather than the bins.
  • Transport your food items in a clear plastic bag and also put them in a screening bin. Keeping your food separate from your carry-on makes it less likely that a TSA agent will need to open your bag for inspection.

Which airlines fly to Southern Illinois?
Cape Air is a well-known carrier servicing Southern Illinois. Search for a ticket to Williamson County Regional Airport (MWA) and you'll have 160 Cape Air flights a month to pick from.
How can I find cheap tickets to Southern Illinois?
A useful strategy for scoring cheap tickets is to be flexible with your travel dates. Begin with searching for your flight to Southern Illinois, then click on the "flexible dates" box to compare prices for nearby days. Want another tip? Book in advance. To give you an idea of costs, was the lowest price for a flight to Southern Illinois in the last seven days.
How much is a flight to Southern Illinois?
In the last seven days, round-trip tickets to Southern Illinois sold for as low as and reached a maximum of . For one-way trips taking off from (), the lowest amount paid during this same period was .
What are the most popular airports to fly into in Southern Illinois?
The main gateway to Southern Illinois, about 160 flights cruise into Williamson County Regional Airport (MWA) each month. Keep an eye out for a rewarding deal, lock in your seat and get set to discover this sensational region.
When is the cheapest time to fly to Southern Illinois?
If you'd rather spend your holiday savings enjoying Southern Illinois rather than on your trip there, jet off earlier in the week. The most economical day to travel is usually Tuesday, with Monday close behind. With many folks keeping their travel to weekends, Saturday tends to have the most expensive airfares.
How much is a plane ticket to Southern Illinois?
In the last seven days, plane tickets varied between and . Check out our sensational deals to Southern Illinois, make a booking and then get ready for your getaway!
Which airlines with flights to Southern Illinois employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented additional actions and measures to help their passengers get back in the air. Here are some great examples:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.