Southern Illinois Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southern Illinois hotels

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.5 star property
Mount Vernon
9.6 out of 10, Exceptional, (1,697 reviews)
"Great breakfast, friendly staff, and clean room. "
United States
Debra
The price is €107
includes taxes & fees
18 May - 19 May
Drury Plaza Hotel Mt. Vernon

Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham
2.5 star property
Effingham
9.6 out of 10, Exceptional, (734 reviews)
"We had an excellent stay at the Fairfield in Effingham. The rooms were immaculate and recently updated, and the staff went above and beyond to make us feel welcome. Check-in was quick and easy, and everyone we interacted with was friendly and professional. The location was convenient, the amenities were great, and the overall atmosphere was relaxing and enjoyable. We would definitely stay here again and highly recommend this hotel to anyone looking for a comfortable and stress-free experience."
United States
Melea
The price is €122
includes taxes & fees
24 May - 25 May
Hampton Inn & Suites Effingham

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1,003 reviews)
"The Sauna and pool makes the stay here worth every penny. 4 stars for the breakfast and gym, and 5 stars for everything else."
United States
Sage
The price is €132
includes taxes & fees
17 May - 18 May
Holiday Inn Express & Suites Effingham by IHG

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1,006 reviews)
"Excellent breakfast and had great "biscuits and gravy ""
United States
William
The price is €114
includes taxes & fees
7 Jun - 8 Jun
La Quinta Inn & Suites by Wyndham Effingham

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,012 reviews)
"Breakfast and eating area was excellent "
United States
Susan
The price is €101
includes taxes & fees
1 Jun - 2 Jun
Drury Inn & Suites Marion

The Principal Hotel

The Principal Hotel
3.5 star property
Columbia
9.8 out of 10, Exceptional, (262 reviews)
"Highly recommend will stay again!"
United States
Mark
The price is €106
includes taxes & fees
12 May - 13 May
The Principal Hotel

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,046 reviews)
"Great, place to stay."
United States
Daniel
The price is €108
includes taxes & fees
17 May - 18 May
Comfort Suites Mount Vernon

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1,007 reviews)
"Great breakfast, easy access, close to shopping and dining."
United States
Linda
The price is €87
includes taxes & fees
7 Jun - 8 Jun
Country Inn & Suites by Radisson, Effingham, IL

Best Western Delta Inn

Best Western Delta Inn
2.5 star property
Effingham
9.2 out of 10, Wonderful, (1,005 reviews)
"Clean facility and room, great staff, beds are very comfortable, good breakfast. I’d stay there again. "
United States
James
The price is €105
includes taxes & fees
5 Jun - 6 Jun
Best Western Delta Inn

Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG
3.5 star property
Effingham
9.0 out of 10, Wonderful, (675 reviews)
"Nice, clean place to stay during a road trip!"
United States
Renee
The price is €105
includes taxes & fees
7 Jun - 8 Jun
Holiday Inn Effingham by IHG

Best Western Plus MidAmerica Hotel

Best Western Plus MidAmerica Hotel
2.5 star property
Mascoutah
9.0 out of 10, Wonderful, (1,012 reviews)
"Good breakfast! Nice place to stay"
United States
Chrisandra
The price is €110
includes taxes & fees
17 May - 18 May
Best Western Plus MidAmerica Hotel

Cobblestone Inn & Suites - Altamont

Cobblestone Inn & Suites - Altamont
2.5 star property
Altamont
9.6 out of 10, Exceptional, (852 reviews)
"Great place to stay"
United States
Tonya
The price is €91
includes taxes & fees
12 May - 13 May
Cobblestone Inn & Suites - Altamont

Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,012 reviews)
"Clean, quiet and the beds were comfortable."
United States
Angela
The price is €109
includes taxes & fees
24 May - 25 May
Holiday Inn Express & Suites Mount Vernon by IHG

Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
4.5 star property
Carterville
9.4 out of 10, Exceptional, (447 reviews)
"Excellent pool and hot tub, indoors and outdoors Very clean property indoors, and outdoors Restaurants OK Staff vary accommodating"
United States
Randolph
The price is €118
includes taxes & fees
14 May - 15 May
Walker's Bluff Casino Resort

Fairfield Inn & Suites Marriott Effingham

Fairfield Inn & Suites Marriott Effingham
3.0 star property
Effingham
9.0 out of 10, Wonderful, (495 reviews)
"Front desk attendant was fantastic."
United States
Richard
The price is €99
includes taxes & fees
7 Jun - 8 Jun
Fairfield Inn & Suites Marriott Effingham

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (963 reviews)
"The property in conveniently located to Rend Lake State Park right off the interstate. I found the property clean and the staff attentive to your needs. "
United States
Jim
The price is €80
includes taxes & fees
18 May - 19 May
SureStay Hotel by Best Western Whittington Rend Lake

Baymont by Wyndham Effingham

Baymont by Wyndham Effingham
2.5 star property
Effingham
8.2 out of 10, Very good, (1,027 reviews)
"Convenient location and great staff. Would stay again"
United States
Janet
The price is €72
includes taxes & fees
19 May - 20 May
Baymont by Wyndham Effingham

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 star property
Vandalia
8.4 out of 10, Very good, (1,009 reviews)
"The room was ok and breakfast was pretty good. I would stay there again."
United States
Charlotte
The price is €64
includes taxes & fees
17 May - 18 May
Quality Inn & Suites Vandalia near I-70 and Hwy 51

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL
3.0 star property
O'Fallon
9.6 out of 10, Exceptional, (1,005 reviews)
"Rooms are clean and the staff is helpful and efficient."
United States
Mary
The price is €104
includes taxes & fees
24 May - 25 May
Drury Inn & Suites St. Louis O'Fallon, IL

Comfort Suites Mattoon East

Comfort Suites Mattoon East
2.5 star property
Mattoon
8.8 out of 10, Excellent, (946 reviews)
"Had a great stay, lots to do in area as well."
United States
Lee Martin
The price is €88
includes taxes & fees
11 Jun - 12 Jun
Comfort Suites Mattoon East
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in Southern Illinois

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southern Illinois attractions

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau

Top Southern Illinois Hotel Reviews

More cheap stays in Southern Illinois

Explore a world of travel with Expedia