Southern Illinois Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southern Illinois hotels

Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG
2.5 star property
Effingham
9.4 out of 10, Exceptional, (1,003 reviews)
"Room was clean, staff was very pleasant, breakfast was delicious and plentiful and we were able to enjoy all amenities. "
United States
Laura
The price is €104
includes taxes & fees
22 Feb - 23 Feb
Holiday Inn Express & Suites Effingham by IHG

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL
2.5 star property
Effingham
8.8 out of 10, Excellent, (1,004 reviews)
"Clean, friendly staff and good breakfast. Location is excellent. "
United States
Maria
The price is €87
includes taxes & fees
12 Mar - 13 Mar
Country Inn & Suites by Radisson, Effingham, IL

La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham
3.0 star property
Effingham
9.2 out of 10, Wonderful, (1,007 reviews)
"Staff was amazing and the brekfast was good too!"
United States
Kevin
The price is €95
includes taxes & fees
8 Mar - 9 Mar
La Quinta Inn & Suites by Wyndham Effingham

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1,659 reviews)
"Hotel is very clean, nicely furnished and the beds were so comfy!"
United States
Christina
The price is €106
includes taxes & fees
16 Feb - 17 Feb
Drury Plaza Hotel Mt. Vernon

Quality Inn Effingham North

Quality Inn Effingham North
2.5 star property
Effingham
8.4 out of 10, Very good, (1,000 reviews)
"It’s a good place to stay for a reasonable price."
United States
Brenda
The price is €73
includes taxes & fees
22 Feb - 23 Feb
Quality Inn Effingham North

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 star property
Vandalia
8.4 out of 10, Very good, (1,003 reviews)
"Consistently nice place"
United States
Cindy
The price is €57
includes taxes & fees
22 Feb - 23 Feb
Quality Inn & Suites Vandalia near I-70 and Hwy 51

Comfort Suites Effingham Central

Comfort Suites Effingham Central
2.5 star property
Effingham
8.8 out of 10, Excellent, (583 reviews)
"The room was very clean and it was quiet."
United States
Jean
The price is €90
includes taxes & fees
1 Mar - 2 Mar
Comfort Suites Effingham Central

Best Western Delta Inn

Best Western Delta Inn
2.5 star property
Effingham
9.2 out of 10, Wonderful, (1,003 reviews)
"Staff very friendly!"
United States
C. Mark
The price is €84
includes taxes & fees
22 Feb - 23 Feb
Best Western Delta Inn

Super 8 by Wyndham Carbondale

Super 8 by Wyndham Carbondale
2.0 star property
Carbondale
7.4 out of 10, Good, (1,004 reviews)
"Clean room, friendly staff"
Canada
Nirosha
The price is €58
includes taxes & fees
10 Mar - 11 Mar
Super 8 by Wyndham Carbondale

Ramada by Wyndham Vandalia

Ramada by Wyndham Vandalia
2.0 star property
Vandalia
7.8 out of 10, Good, (818 reviews)
"The room was clean, the staff was friendly, respectful and very helpful "
United States
Dianna
The price is €62
includes taxes & fees
12 Mar - 13 Mar
Ramada by Wyndham Vandalia

Holiday Inn Express & Suites Vandalia by IHG

Holiday Inn Express & Suites Vandalia by IHG
2.5 star property
Vandalia
8.8 out of 10, Excellent, (787 reviews)
"Clean room & staff was great!"
United States
Lori
The price is €105
includes taxes & fees
22 Feb - 23 Feb
Holiday Inn Express & Suites Vandalia by IHG

Innkeeper Motel

Innkeeper Motel
2.0 star property
Hamel
6.8 out of 10, (3 reviews)
"Good value"
United States
ian
The price is €59
includes taxes & fees
22 Feb - 23 Feb
Innkeeper Motel

Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG
3.5 star property
Effingham
9.0 out of 10, Wonderful, (663 reviews)
"Nice place with bar and restaurant on site."
United States
Steve
The price is €103
includes taxes & fees
22 Feb - 23 Feb
Holiday Inn Effingham by IHG

Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham
2.5 star property
Effingham
9.6 out of 10, Exceptional, (709 reviews)
"Very clean, nice hot breakfast, and kind staff. "
United States
Erin
The price is €107
includes taxes & fees
22 Feb - 23 Feb
Hampton Inn & Suites Effingham

Cobblestone Inn & Suites - Altamont

Cobblestone Inn & Suites - Altamont
2.5 star property
Altamont
9.6 out of 10, Exceptional, (816 reviews)
"great stay"
United States
Susan
Cobblestone Inn & Suites - Altamont

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,006 reviews)
"Clean rooms, great food, friendly staff"
United States
John
The price is €76
includes taxes & fees
8 Mar - 9 Mar
Drury Inn & Suites Marion

Baymont by Wyndham Effingham

Baymont by Wyndham Effingham
2.5 star property
Effingham
8.0 out of 10, Very good, (1,003 reviews)
"The hotel location was good, the room was clean, and the staff was kind."
United States
JoAnn
The price is €65
includes taxes & fees
3 Mar - 4 Mar
Baymont by Wyndham Effingham

Best Western Marion Hotel

Best Western Marion Hotel
2.5 star property
Marion
8.2 out of 10, Very good, (1,002 reviews)
"I was satisfied with my stay. "
United States
Frankie
The price is €80
includes taxes & fees
13 Feb - 14 Feb
Best Western Marion Hotel

Comfort Suites Mattoon East

Comfort Suites Mattoon East
2.5 star property
Mattoon
8.8 out of 10, Excellent, (901 reviews)
"Great stay!"
United States
Michael
The price is €81
includes taxes & fees
15 Feb - 16 Feb
Comfort Suites Mattoon East

Ramada by Wyndham Effingham

Ramada by Wyndham Effingham
3.0 star property
Effingham
7.6 out of 10, Good, (1,004 reviews)
"Room was clean, they had painted part of the room the ceiling was not finished. Staff very helpful and friendly."
United States
Edward
The price is €55
includes taxes & fees
15 Feb - 16 Feb
Ramada by Wyndham Effingham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in Southern Illinois

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southern Illinois attractions

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

Southern Illinois which includes a sunset, forests and landscape views
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau

Top Southern Illinois Hotel Reviews

More cheap stays in Southern Illinois

Explore a world of travel with Expedia