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Southern Illinois Hotel Guide - Business Hotels in Southern Illinois, Illinois

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Check availability on Southern Illinois Business Hotels

Tonight
6 Sept - 7 Sept
Tomorrow
7 Sept - 8 Sept
Next weekend
11 Sept - 13 Sept
In two weeks
18 Sept - 20 Sept

Our top choices for Southern Illinois business-friendly hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.
A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.
A spacious lobby with a reception desk, seating area, and glass doors leading outside.
A hotel room with two beds, a desk with a flat-screen TV, a chair, and a lamp.

1. Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
Mount Vernon
United States
Kirstyn
€108
includes taxes & fees
13 Sept - 14 Sept
Drury Plaza Hotel Mt. Vernon
A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and illuminated pillars.
An indoor swimming pool with clear lane markings, a lifeguard chair, and a window providing natural light.
A hotel reception area with two reception desks, a wall-mounted digital screen, and a security camera.
A modern kitchen with a wooden cabinet, coffee maker, and storage shelves.

2. Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
Mount Vernon
United States
Abigail
€108
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express & Suites Mount Vernon by IHG
A hotel lobby with a reception desk, seating area, and a large screen TV.
A Comfort Suites hotel with a spacious parking lot and a modern brick facade.
A hotel dining area with a large wooden table, red upholstered chairs, a flat-screen TV mounted above the fireplace, and a kitchen area in the background.
A hotel room with a marble bathtub, a wooden dining table with chairs, a bed with a headboard, and a nightstand with lamps.

3. Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
Mount Vernon
United States
James
€114
includes taxes & fees
13 Sept - 14 Sept
Comfort Suites Mount Vernon
An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.
A modern indoor seating area with leather chairs and tables, a central round table, and a staircase leading to an upper level.
A spacious lobby with high ceilings, a wooden ceiling, and a large wall with vertical panels. There are seating areas with sofas and chairs, and a staircase on the right.
An outdoor patio area with tables and chairs, large windows, and red umbrellas.

4. DoubleTree by Hilton Mt. Vernon

DoubleTree by Hilton Mt. Vernon
Mount Vernon
United States
Samuel
€124
includes taxes & fees
1 Oct - 2 Oct
DoubleTree by Hilton Mt. Vernon
A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.
A hotel with a flat facade, multiple windows, and a sign indicating it is a 'SureStay Hotel by Best Western'.
A dining area with round tables and chairs, a kitchen with a countertop and appliances, and a hallway leading to another room.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

5. SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
Whittington
United States
MARK
€77
includes taxes & fees
13 Sept - 14 Sept
SureStay Hotel by Best Western Whittington Rend Lake
A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.
A hotel with a brick facade, a flagpole with an American flag, and a parking lot with several cars.
A hotel room with a desk, a lamp, a flat-screen TV, a telephone, a microwave, and a trash bin.
A reception area with a counter, a clock, and a chandelier.

6. Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
Mount Vernon
United States
Matthew W,
€76
includes taxes & fees
7 Sept - 8 Sept
Super 8 by Wyndham Mt. Vernon IL
An indoor swimming pool with a diving board, a changing room, and a tiled floor.
A living room with two gray armchairs, a coffee table, a flat-screen TV, and a fireplace. There are large windows and a potted plant.
A Days Inn building with a flat roof, large windows, and a sign above the entrance.
A hotel room with two beds, a desk, a window with curtains, and a painting on the wall.

7. Days Inn by Wyndham Mount Vernon

Days Inn by Wyndham Mount Vernon
Mount Vernon
United States
Asa
€71
includes taxes & fees
8 Sept - 9 Sept
Days Inn by Wyndham Mount Vernon
A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.
An indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls. There are lounge chairs and a small seating area with tables.
A spacious lobby with a large seating area, a reception desk, and a television.
A hotel room with two beds, a large window with curtains, a wall-mounted lamp, and a patterned carpet.

8. Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
Centralia
United States
Corey
€134
includes taxes & fees
7 Sept - 8 Sept
Best Western Plus Centralia Hotel & Suites
A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.
A compact kitchenette with a refrigerator and an ice dispenser.
A hotel room with two beds, a desk, and a window with a view.
A reception area with a stone wall, a round mirror, a reception desk, and a computer setup.

9. Best Western U. S. Inn

Best Western U. S. Inn
Nashville
United States
Arilla
€103
includes taxes & fees
1 Oct - 2 Oct
Best Western U. S. Inn
A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.
A hotel lobby with a marble floor, a reception area with a '12 & VINE' sign, and a dining area with orange chairs and chandeliers.
A casino interior with slot machines, a large chandelier, and a carpeted floor.
A hotel reception desk with a modern chandelier, a sign indicating 'SPA' coming soon, and two receptionists at their stations.

10. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
Carterville
United States
Frankie
€120
includes taxes & fees
7 Sept - 8 Sept
Walker's Bluff Casino Resort
View all properties

Top Southern Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

10/10 Excellent
"Excellent"
Matthew 2-night trip
Posted 4 hours ago
Drury Plaza Hotel Mt. Vernon
Quality Inn & Suites Metropolis I-24

Quality Inn & Suites Metropolis I-24

10/10 Excellent
"Room was clean and bright, the air was on so Ithe room felt amazing and the pool was warm."
Cierra 3-night trip
Posted 8 hours ago
Quality Inn & Suites Metropolis I-24
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

10/10 Excellent
"Excellent"
Van 1-night trip
Posted 1 day ago
Comfort Suites Mount Vernon
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

10/10 Excellent
"Clean comfortable room and a great breakfast."
Larry 1-night trip
Posted 1 day ago
Country Inn & Suites by Radisson, Effingham, IL
Quality Inn O'Fallon - St. Louis - Shiloh

Quality Inn O'Fallon - St. Louis - Shiloh

10/10 Excellent
"Location great"
Laura 1-night trip
Posted 1 day ago
Quality Inn O'Fallon - St. Louis - Shiloh
Best Western Delta Inn

Best Western Delta Inn

10/10 Excellent
"good work"
Don 1-night trip
Posted 4 days ago
Best Western Delta Inn
Comfort Suites Fairview Heights - St. Louis

Comfort Suites Fairview Heights - St. Louis

8/10 Good
"This was a place we stopped to stay over night after a long day of driving. The property its self was old and a bit musty smelling, however, it was well maintained and the rooms were clean. It could use some cleaning in the hallways. The price was right and it served it purpose for the night."
Danielle 1-night trip
Posted 6 days ago
Comfort Suites Fairview Heights - St. Louis
Super 8 by Wyndham Fairview Heights-St. Louis

Super 8 by Wyndham Fairview Heights-St. Louis

8/10 Good
"I have stayed in Super 8's in various cities. The room was decently clean but had an old carpet smell. The breakfast choices have diminished from what they were 3 years ago - just coffee, juice, bagels, white bread - no yogurt, eggs, or even cereal and milk the day I stayed."
Kathleen 2-night trip
Posted 10 days ago
Super 8 by Wyndham Fairview Heights-St. Louis

Frequently asked questions

How much do business-friendly hotels in Southern Illinois cost?
You'll pay between €71 and €134 per night for business-friendly hotels in Southern Illinois. Awesome deals on properties that cater to work-related travellers are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Illinois?
That depends on your destination in Southern Illinois. Many business travellers to O'Fallon like to base themselves at Drury Inn & Suites St. Louis O'Fallon, IL. This 3-stars property comes with a swimming pool and complimentary breakfast. Hampton Inn O'Fallon is another top option if you're attending a conference or working remotely in O'Fallon. A swimming pool and an electric car charging station are among the handy amenities at this 2.5-stars getaway. When work takes you on the road, you can choose from multiple business-friendly hotels in Southern Illinois that have a total average guest review rating of 8.5.
How many business-friendly hotels are there in Southern Illinois?
Pick from 149 business-friendly hotels in Southern Illinois. Wherever your job is taking you, Expedia makes it a breeze to find the ideal space with the amenities you want.
What are the best cheap business-friendly hotels in Southern Illinois?
Keep costs low with Expedia's business-friendly hotels in Southern Illinois that start at €71 per night. A cheaper property in O'Fallon is Hampton Inn O'Fallon. Corporate guests rate it highly for its many amenities, including an electric car charging station and a swimming pool. If you're basing yourself in Effingham, choose Holiday Inn Express And Suites Effingham, an IHG Hotel. A swimming pool and a garden are among the conveniences provided for both business and leisure travellers. You'll find loads of free and interesting things to do wherever you go in Southern Illinois. If you have a meeting or conference in O'Fallon, try to find time to visit St. Clair Bowl. You can also go sightseeing for a song in Effingham. Mid America Motorworks, My Garage Museum is one of the best free attractions here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southern Illinois that are also business friendly?
You'll discover some terrific family-friendly hotels that are also business friendly in Southern Illinois. If you're travelling to O'Fallon, look up Drury Inn & Suites St. Louis O'Fallon, IL. It offers handy amenities such as complimentary breakfast and a laundry service and has a 3-stars rating. Another property worth considering is Drury Inn & Suites St. Louis Fairview Heights. This 3-stars stay in O'Fallon is ideal for both leisure and business travellers and offers complimentary breakfast, a laundry service and much more. Once you've gotten work out of the way, get out and discover O'Fallon with the kids. Favourite family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southern Illinois with Expedia?
At Expedia, we make it our job to help you locate an amazing stay at the right price. From luxurious, corporate-friendly properties to affordable hotels filled with handy amenities, you'll have your next work trip booked in a few easy clicks.
How can I find cheap business-friendly hotels in Southern Illinois?
When you're travelling for work in Southern Illinois, our "business friendly" filter will help you find the ideal hotel. From free WiFi to workspaces and meeting rooms, they have the amenities you need to be productive. Another useful tip? Refine your search by your budget and preferred star rating to view the most affordable options.
What is there to do in Southern Illinois near my business-friendly hotel?
Southern Illinois has so much to see and do, it can be tricky to figure out where to start. If you're spending a few nights in O'Fallon, The Edge is a much-loved attraction here.

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